It turns out that some commonly found chemicals in household products are actually hazardous to our brain health. A recent study found that these chemicals have a harmful effect on brain cells called oligodendrocytes. The harmful chemicals are quaternary compounds (found in some disinfectant products and personal care products) and some flame retardants found in household items such as furniture and electronics.
Oligodendrocytes are cells in the central nervous system that form the myelin sheath (a layer that covers and protects nerve cells) in the brain and spinal cord. Damage to the myelin sheath underlies some neurological diseases, such as multiple sclerosis.
The researchers felt that exposure to these chemicals that damage oligodendrocytes may be a risk factor for neurological diseases. In other words, you don't want to damage these cells. Pregnant women (developing baby) and children (developing brains!) are especially vulnerable.
Bottom line: Avoid disinfecting or cleaning supplies that say they contain "quaternary compounds" and try not to buy products containing flame retardants. Check labels!
From Science Daily: Common household chemicals pose new threat to brain health, study finds
A team of researchers from the Case Western Reserve University School of Medicine has provided fresh insight into the dangers some common household chemicals pose to brain health. They suggest that chemicals found in a wide range of items, from furniture to hair products, may be linked to neurological conditions like multiple sclerosis and autism spectrum disorders.
Neurological problems impact millions of people, but only a fraction of cases can be attributed to genetics alone, indicating that unknown environmental factors are important contributors.
The new study published today in the journal Nature Neuroscience, discovered that some common home chemicals specifically affect the brain's oligodendrocytes, a specialized cell type that generates the protective insulation around nerve cells.
"Loss of oligodendrocytes underlies multiple sclerosis and other neurological diseases," said the study's principal investigator, Paul Tesar, the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics and director of the Institute for Glial Sciences at the School of Medicine. "We now show that specific chemicals in consumer products can directly harm oligodendrocytes, representing a previously unrecognized risk factor for neurological disease."
On the premise that not enough thorough research has been done on the impact of chemicals on brain health, the researchers analyzed over 1,800 chemicals that may be exposed to humans. They identified chemicals that selectively damaged oligodendrocytes belong to two classes: organophosphate flame retardants and quaternary ammonium compounds. Since quaternary ammonium compounds are present in many personal-care products and disinfectants, which are being used more frequently since the COVID-19 pandemic began, humans are regularly exposed to these chemicals. And many electronics and furniture include organophosphate flame retardants.
The researchers used cellular and organoid systems in the laboratory to show that quaternary ammonium compounds cause oligodendrocytes to die, while organophosphate flame retardants prevented the maturation of oligodendrocytes.
They demonstrated how the same chemicals damage oligodendrocytes in the developing brains of mice. The researchers also linked exposure to one of the chemicals to poor neurological outcomes in children nationally.
"We found that oligodendrocytes -- but not other brain cells -- are surprisingly vulnerable to quaternary ammonium compounds and organophosphate flame retardants," said Erin Cohn, lead author and graduate student in the School of Medicine's Medical Scientist Training Program. "Understanding human exposure to these chemicals may help explain a missing link in how some neurological diseases arise."