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Farm  Credit: Wikipedia

People everywhere are dismayed by the sheer quantity and number of "forever chemicals" that contaminate our environment and our bodies. Unfortunately, we all have forever chemicals (PFOS, PFAS) in us (but in varying amounts). It turns out that the US government played a role in the forever chemicals found in our food, and why so many farms are now forever contaminated.

Decades ago, the US EPA (Environmental Protection Agency) started encouraging the use of biosolids or black sludge (the sludge that is left over at wastewater treatment plants) as a fertilizer on farms in the United States. That the use of this biosolid sludge could cause problems and harms has been known for decades.

The sludge contains heavy metals and PFOS and PFAS chemicals (forever chemicals because they bioaccumulate and persist in the environment). The chemicals are linked to all sorts of health harms (e.g., cancers, reproductive problems). [Note: We are exposed to forever chemicals in many products and in the environment daily.]

Well.... of course, applying this sludge across farms has now resulted in persistent contamination of both the soil and water at those farms, but also in the animals being raised on those farms. Estimates are up to a fifth of farms are contaminated. And yet the EPA still feels this practice of applying contaminated sludge is OK!!!

Very few mass media articles actually discuss the government's role in contaminating farms (and in this way our food). So the following 2 articles were a pleasant surprise - horrifying to read, but all true.

Bottom line: Eat as much organic food, or what you grew yourself, as much as possible. The biosolid sludge is not allowed on organic farms. Also, when buying top soil (dirt) or fertilizer for your garden, avoid any product that says "biosolids" in it. (e.g., Milorganite  - known to contain PFAS and PFOS) Buy organic soil and fertilizer, if you can.

Until recently, very few mass media articles actually discussed the government's role in contaminating farms (and in this way our food). So the following 2 articles are horrifying to read, but all true.

(1) Excerpts from the New York Times: Something’s Poisoning America’s Land. Farmers Fear ‘Forever’ Chemicals.

For decades, farmers across America have been encouraged by the federal government to spread municipal sewage on millions of acres of farmland as fertilizer. It was rich in nutrients, and it helped keep the sludge out of landfills.

But a growing body of research shows that this black sludge, made from the sewage that flows from homes and factories, can contain heavy concentrations of chemicals thought to increase the risk of certain types of cancer and to cause birth defects and developmental delays in children.

Known as “forever chemicals” because of their longevity, these toxic contaminants are now being detected, sometimes at high levels, on farmland across the country, including in Texas, Maine, Michigan, New York and Tennessee. In some cases the chemicals are suspected of sickening or killing livestock and are turning up in produce. Farmers are beginning to fear for their own health.

(2) Excerpts from Yahoo News: Startling investigation exposes mountains of toxic sludge threatening America's food chain: 'People are scared to death'

A fertilizer used for decades by U.S. farms contains toxic chemicals that are being blamed for halting agricultural operations, killing animals, and endangering our food supply. ...continue reading "The Government’s Role In Why Many Farms Are Contaminated With Forever Chemicals"

Intestines Credit: Wikipedia

A number of things can contribute to the development of colorectal cancer (colon cancer), such as highly processed foods, eating a Western diet low in fiber, or the bacteria Fusobacterium nucleatum. These are known to contribute to or result in the gut microbiome being out of whack (gut dysbiosis).

Another factor is perfluorooctanesulfonic acid (PFOS), which are chemicals we all are exposed to in everyday life. A recent study illustrated how long-term exposure to PFOS can also contribute to the development of colorectal cancer because of the effect it has on intestinal cells in the intestines.

PFAS and PFOS (Per- and polyfluoroalkyl substances) are called forever chemicals due to their buildup (bioaccumulation) and persistence in people and the environment. We get exposure to these chemicals various ways - through ingestion (food and water), inhalation (dust), and from absorption through the skin (e.g., personal care products).

They are widely used chemicals, such as in non-stick coatings (e.g., pots and pans) and stain and water repellent products. We get exposure to these chemicals various ways - through ingestion (food and water), inhalation (dust), and from absorption through the skin (e.g., personal care products).

They are in all of us at varying levels, and they have harmful health effects. Effects include cancer, reproductive harm (e.g., poorer semen quality), birth defects, lowered sex and growth hormones in children, thyroid disease, immune effects, and liver and kidney damage. They are endocrine disruptors.

The chemical industry would have you think that the newer PFAS chemicals that replace the older ones are "safer", but guess what? They're not. They're very similar chemically, so it shouldn't be surprising that they don't appear to be safer.

Bottom line: You can't totally avoid PFAS chemicals, but you can lower your exposure to them. If possible, avoid products that are water and stain proof or leak-proof, especially if children will be using the product. Don't use nonstick cookware, stain resistant carpeting and fabrics, clothing treated to be water-proof, and synthetic turf. PFAS and PFOS don't have to be mentioned on labels, so it's buyer beware.

From Medical Xpress: Study links 'forever chemical' PFOS with colorectal cancer

A recent University of Kentucky Markey Cancer Center study sheds light on how the environmental pollutant perfluorooctanesulfonic acid (PFOS) may affect our intestines and possibly increase the risk of developing colorectal cancer. ...continue reading "Forever Chemicals Are Linked To Colorectal Cancer"

Recently, another well done study of vitamin D and cancer resulted in disappointing results. Vitamin D supplements showed no benefit in persons with metastatic colorectal cancer (CRC). It did not result in a difference in overall survival outcomes.

In the study, 455 patients with metastatic colorectal cancer were assigned randomly to either high daily vitamin D3 or standard dose vitamin D3, in addition to receiving standard chemotherapy. The high dose vitamin D group received a loading dose of 8000 IU per day for 2 weeks, followed by a maintenance dose of 4000 IU per day until the end of the study. The standard dose vitamin D group received 400 IU per day.

However, there was no difference in "significant progression-free survival benefit". There also was no significant difference in how long people survived in the 2 groups (a median of 25.6 months in the high-dose group, and 27.0 months in the standard dose group).

The study results were disappointing because in laboratory studies vitamin D has anticancer properties. Critics of this study pointed out that vitamin D supplementation may have a role in cancer prevention - but at this point, that is unknown.

From Medscape: High-Dose Vitamin D Disappoints in Metastatic CRC: SOLARIS

The addition of high-dose vitamin D supplementation to standard chemotherapy plus bevacizumab did not result in a significant progression-free survival benefit in patients with metastatic colorectal cancer (CRC) in the SOLARIS study. ...continue reading "Another Vitamin D Study With Disappointing Results"

We all have some pesticide residues in our body, and the levels vary. One way that people are exposed to pesticides is from the foods they eat, specifically non-organic foods. Pesticides that people are exposed to can be measured in the blood and urine. 

A recent review of 72 scientific studies found that people who eat an organic diet have lower pesticide levels in their urine. (Other pesticide exposures are from the environment around us, for example, garden and lawn pesticides.)

The study authors specifically looked at pesticide residues and metabolites of common pesticides such as organophosphates, pyrethroids, 2,4-D, and glyphosate. The most commonly mentioned pesticide residue was from pyrethroids, with 34% of studies finding it in urine. Keep in mind that only a limited number of pesticide residues were looked for. In reality, people are exposed to many more in life, including from non-organic foods that they eat.

Looking at the studies, the researchers found a massive reduction in pesticide residues when an organic diet is adopted. For example, phenol and phosphonate herbicide levels drop 41% to 100% in the studies, and pyrethroid metabolites dropped 16% to 100% [Note: each study had different drops in pesticide residues.]

And yes, you want lower levels of pesticide residues in your body for health reasons. For example, pyrethroids have been associated with numerous health harms, including cancer, endocrine disruption, and reproductive effects.

Bottom line: To lower pesticide levels in your body, eat as many organic foods as possible.

Excerpts from Beyond Pesticides: Review of Pesticide Residues In Urine, Lower Concentrations With Organic Diet

 A literature review, published this month in the Journal of Agricultural and Food Chemistry, explores levels of pesticide residues found in samples of human urine with environmental exposure and dietary intake and confirms prior findings about the benefits of an organic diet. Similar to past findings, lower concentrations of chemicals are detected in the urine of participants who report eating an organic diet. ...continue reading "Eating Organic Foods Lowers Pesticide Levels In the Body"

For several years I've been reporting on the effects of pesticides on bees. Yes, it's all bad because pesticides kill bees. Commonly used pesticides such as pyrethroids that many view as "safe" kill bees. Pyrethroids are broad spectrum insect killers, which means they kill both beneficial bees and other pollinators, as well as potentially harmful insects (mosquitos).

A recent study confirmed that pesticides are a major reason that wild bee populations are significantly down in the US. The researchers found that bee species are about 43% down in areas of heavy pesticide use. They singled out pesticides (insecticides) such as neonicotinoids and pyrethroids as drivers of this bee species reduction. They pointed out that using Integrated Pest Management (IPM) or organic methods would help reduce pesticide use and so help with bee species populations.

This means that businesses (e.g., Mosquito Joe) that apply long-lasting pyrethroids throughout suburban yards and hedges in the US are contributing directly to bee species reduction.

Other studies found that applying pesticides (no matter what kind) to lawns destroys bee populations and reduces the number of bee species. Think of lawns that are not treated with pesticides as having wildflowers, not weeds. These are bee habitats!

From Environmental Health News (EHN): Pesticides may be contributing to the disappearance of bees across the US

A recent study published in Nature Sustainability found that pesticide use may be a major factor in the decline of bee populations within the United States. ...continue reading "Pesticides Are Contributing To Bee Declines"

Something surprising: People with multiple sclerosis don't develop Alzheimer's disease - even if it runs in the family. New research suggests that multiple sclerosis may protect a person from Alzheimer's disease.

The researchers found that the more typical the multiple sclerosis development and symptoms in the person, the less likely they were to have amyloid plaque accumulation in the brain. Amyloid plaques in the brain are hallmarks of Alzheimer's disease.

Accumulation of plaques is generally viewed as the first step that leads to cognitive decline and ultimately Alzheimer's disease.

From Futurity: Multiple Sclerosis May Protect Against Alzheimer's Disease

People with multiple sclerosis are far less likely than those without the condition to have the molecular hallmarks of Alzheimer’s disease, according to new research.

The discovery suggests a new avenue of research through which to seek Alzheimer’s treatments, says Matthew Brier, an assistant professor of neurology and of radiology at Washington University School of Medicine in St. Louis and the study’s first author. ...continue reading "Persons With Multiple Sclerosis Don’t Get Alzheimer’s Disease"

The bacteria Fusobacterium nucleatum is prevalent in periodontal disease (gum disease), but also in some chronic diseases and cancers, such as colorectal cancer. The bacteria F. nucleatum is normally found in the mouth (oral) microbiome, and its numbers increase as periodontal disease inflammation increases.

It is thought that sometimes the bacteria leaves the mouth and travels to other parts of the body, where it can promote cancer and other diseases.

A recent study found that the antibiotic FP 100 (Hygromycin A) totally eliminates the F. nucleatum bacteria in the mouth, and without causing harm to the mouth microbiome or gut microbiome. This is because it is a narrow spectrum antibiotic - only targets the harmful bacteria, and not all (both good and harmful) bacteria. While the study was only done in mice, this is promising and welcome news.

Eliminating the harmful bacteria in the mouth would potentially prevent some chronic diseases and cancers. Now we need further studies to see if this finding holds up in humans.

From Medical Xpress: First narrow-spectrum antibiotic successfully eliminates  Fusobacterium nucleatum, a gum disease pathogen

In a study published in the Journal of Oral Microbiology, ADA Forsyth scientists found that FP 100 (Hygromycin A), a first-in-class, small molecule, narrow-spectrum antibiotic, successfully eradicates Fusobacterium nucleatum without harming the oral or gut microbiomes. ...continue reading "A Promising Antibiotic For Gum Disease"

The province of New Brunswick in Canada is home to a mysterious cluster of brain diseases in some of its residents - even in young persons in their 20s and 30s. The numbers of persons stricken (currently 430) with neurodegenerative brain diseases and dying is growing, and at this time no one knows exactly why this is happening.

One possibility is pesticide exposure, especially the pesticide (herbicide) glyphosate. Glyphosate is heavily used in the province in the forest industry, which is also a main industry. The herbicide is heavily used in clear cuts and tree plantations.

Lab tests found incredibly high levels of the pesticide glyphosate in the persons with the neurological symptoms. But after these results were revealed, the provincial government basically shut all research down. A doctor who was instrumental in bringing attention to this mysterious brain disease cluster was muzzled. Uh oh... a political and industry cover up?

The NY Times did an in-depth investigation, and the article written by Greg Donohue makes for fascinating reading.  They All Got Mysterious Brain Diseases. They're Fighting to Learn Why.

The article pointed out that recent studies have shown that glyphosate crosses the blood-brain barrier, and that chronic exposure can lead to neurological inflammation that can trigger Alzheimer’s disease. There is a link between glyphosate and an increased risk for Parkinson's disease and other health problems, including cancer.

A further discussion of that investigation and the role of pesticides (glyphosate) in brain diseases. Good list of references for more information. Excerpts from Beyond Pesticides: One Of World's Largest Dementia Clusters In Young People May Be Tied To High Blood Levels Of Glyphosate

A piercing investigative article in the August 14 New York Times by journalist Greg Donahue reveals the abandonment of a group of brain disease patients in an area of Canada with forestry management for paper products, agriculture, and large amounts of pesticide use, including glyphosate. ...continue reading "Brain Disease Cluster In Canada"

Dying pollinator

There was a rare sighting of an insect pollinator in my yard recently. Unfortunately, it was dying. I suspect that pesticides were the cause of the slow death.

The ordinary person has no clue how damaging pesticide applications on their lawns and plants can be to insects living nearby. To pollinators (e.g., bees and wasps). To entire insect and bird ecosystems.

On the day I saw the dying insect pollinator, an immediate neighbor had not one, but two pesticide applications by two different services in one day! One service was for their lawn, and the second one was for mosquitos (using pyrethroid and cypermethrin insecticides) with a device that looks like a leaf blower. This device is held at waist-height (a high volume application).

Soon after that I found the dying, but still twitching, pollinator on the hood of my car (close to the property line). As I've discussed before, since the neighbor started mosquito pesticide applications 2 years ago, I rarely see a bee, wasp, or butterfly in my organic yard. At most, maybe one bee every 2 months? Before that, there were many daily.

The mosquito applications are done using cypermethrin and pyrethroid insecticides (which are synthetic pesticides, e.g., made by Fendona). Pyrethroids are known to be highly toxic to pollinators such as bees and wasps, and there is growing evidence of harms to humans (here, here).

Of course, when pesticides are applied, they drift and travel to non-target neighboring areas. It's sad. But totally legal.

Thermometer Credit: Wikipedia

It turns out that older women are more susceptible to high heat and humidity then older men. Older women feel it more! (In science speak: women are physiologically more vulnerable to high heat and humidity, that is, heat stress vulnerability)

Researchers found that middle-aged and older women were affected by heat at lower temperature and humidity combinations than middle-aged and older men. Women between the ages of 40 and 64 are as vulnerable as men 65 years and older. The researchers said that biological sex (male or female) and age appear to be the primary drivers of heat vulnerability among healthy people.

There were no differences in heat vulnerability between male and female younger adults. Also, fitness of individuals made very little difference in heat vulnerability.

Researchers tested the heat thresholds (combined heat and humidity) of 72 participants between the ages of 42 and 92 years in a specialized environmental chamber. Participants swallowed a special device which measured their core temperature throughout the experiment. NOTE: When core temperatures rise, people are more vulnerable to heat exhaustion, heat stroke, and even death.

From Science Daily: Older women more vulnerable to heat than their male peers, researchers find

As global climate change causes extreme heat waves to become more common around the world, epidemiological studies have shown that heat kills more women than men. Now, a new study by researchers at Penn State has found that older women are physiologically more vulnerable to high heat and humidity than older men, and that women between the ages of 40 and 64 are as vulnerable as men 65 years of age or older. This is the first study to determine this disparity exists due to physiological differences rather than because women live longer than men -- leaving a larger population of older women than older men. ...continue reading "Older Women Are More Vulnerable to High Summer Heat"