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A recent study of pregnant women found new health problems with the pesticide glyphosate, which is the active ingredient in the weedkiller Roundup (made by Monsanto). The researchers found that women  with higher levels of glyphosate are more likely to have shorter pregnancies. Another major finding was that almost all the pregnant women (93%) in this study had detectable levels of glyphosate in their urine. I posted about this study earlier, but now it has been published in the journal Environmental Health.

All the pregnant women were living in central Indiana (in the cornbelt) in a mix of areas (suburban, urban, and rural), and whether they had well or public drinking water. In case you don't know, it is not good for a baby to be born early, and there can be lifelong health consequences - so every extra week (till full term) is good during pregnancy. The researchers found higher levels of glyphosate in women living in rural areas (farm areas) and those drinking greater than 24 ounces a day of caffeinated beverages. The researchers thought that diet (food) and inhalation of contaminated dust were the major ways that the glyphosate got into the pregnant women.

Glyphosate is the most heavily used herbicide (a type of pesticide) in the world. Nearly 300 million pounds were applied in the U.S. in 2015, with much of the application in the Midwest. Scroll down to see a USGS map of glyphosate (Roundup) use in 2015 in the US. You can see that incredibly huge amounts of glyphosate are used in the midwest on farmland - greater than 88.6 pounds per square mile! (it's the dark brown areas on the map). Top crops it's used on are corn, soybeans, and canola, especially genetically modified Roundup Ready crops. It is also used as a dessicant right before harvest ("preharvest") on many crops. This is why crops have glyphosate residues on them, and why so many streams and lakes are contaminated (due to agricultural runoff). About 90% of corn and soybean crops grown in the United States are Roundup Ready, and then these grains are used in most processed foods. Note: glyphosate (Roundup) can not be used on organic crops.

The herbicide has been linked to a number of health problems, including cancer, birth defects, endocrine disruption, and reproductive problems. (Posts on glyphosate.)  There are currently hundreds of lawsuits from farmers and others claiming that Roundup gave them cancer.

...continue reading "Popular Weedkiller Found In Pregnant Women"

The researchers of a recent study caution about the regular use of lavender and tea tree essential oils (e.g. in lotions or soaps) - that the oils may act as endocrine disruptors (chemicals that disrupt hormones and their actions in the body). Earlier research found a link between regular use of lavender essential oil and tea tree oil and abnormal breast growth in boys - called prepubertal gynecomastia. The condition went away after they stopped using the products.

Now researchers examined 8 common chemical components of lavender and tea tree oils for endocrine disrupting activity in lab tests - and yes, they found varying degrees of endocrine-disrupting activity in the chemicals. The researchers (from the National Institute of Environmental Health Sciences or NIEHS) warn that endocrine disrupting chemicals found in these 2 essential oils are also found in 65 other essential oils.

Note that essential oils are widely available, but they are not regulated by the FDA. Bottom line: No matter the age, avoid prolonged use of lavender and tea tree oil in personal care products, including "aromatherapy" -  especially important for children and pregnant women. The results were presented today at the 100th annual meeting of the Endocrine Society (ENDO) in Chicago. From Science Daily:

Chemicals in lavender and tea tree oil appear to be hormone disruptors

A new study lends further evidence to a suspected link between abnormal breast growth in young boys -- called prepubertal gynecomastia -- and regular exposure to lavender or tea tree oil, by finding that key chemicals in these common plant-derived oils act as endocrine-disrupting chemicalsLavender and tea tree oil are among the so-called essential oils that have become popular in the United States as alternatives for medical treatment, personal hygiene and cleaning products, and aromatherapy. Various consumer products contain lavender and tea tree oil, including some soaps, lotions, shampoos, hair-styling products, cologne and laundry detergents.   ...continue reading "Are Some Essential Oils Endocrine Disruptors?"

Once again a study found that a high fiber diet feeds beneficial gut microbes and causes changes in the gut microbe community (the microbiome). What's new in this study is that eating the high fiber diet had health benefits for people with type 2 diabetes - that it lowered their blood sugar levels (better blood glucose control), resulted in  greater weight loss, and better lipid levels. And that when these gut microbes were transplanted into mice - they had similar health effects (better regulation of blood sugar). Which showed it was the microbes that caused the beneficial effects.

What foods are high-fiber foods? Fruits, vegetables, whole grains, nuts, seeds, and legumes (beans). [See Feeding Your Gut Microbes] From The Scientist:

High-Fiber Diet Shifts Gut Microbes, Lowering Blood Sugar in Diabetics

A diet high in fiber can reshape the gut microbiome, helping people with type 2 diabetes stay healthy. A study published yesterday (March 8) in Science found that when patients with the condition ate a high-fiber diet, they had an abundance of microbial species that helped to reduce blood sugar and regulate weight compared with cohorts who ate a less fiber-rich diet ...continue reading "High Fiber Diet Is Beneficial For Those With Type 2 Diabetes"

People often wonder if there are any health benefits to buying organic milk versus conventional milk. And further, how about grass-fed organic milk? Now a recent study answers that question nicely with regards to beneficial fatty acids. Keep in mind that ideally (for health benefits) want fewer omega-6 fatty acids, and more omega-3 fatty acids, with a ratio close to 1. Guess which is the healthiest? The 100% grass-fed organic milk (ratio of .95 - just about 1) is best, then the organic milk, and in last place - conventional milk. Why is that? It's due to different food and grazing requirements (see below). From Beyond Pesticides:

Study Finds Grass-Fed and Organic Milk to be Healthier Than Conventional

Milk from 100% grass-fed cows has higher levels of beneficial fatty acids than conventional and even organic milk, according to a study published by an international team of scientists in the journal Food Science and Nutrition. The research follows up on data published in 2013, which compared only conventional and organic milk, finding organic milk contained 62 percent more omega-3 fatty acids and 25 percent fewer omega-6s

The study compared the composition of several fatty acids within the three types of milk tested (conventional, organic, and grass-fed). Of primary concern was the ratio of omega 6 to omega 3 fatty acids. Although omega 6s are not necessarily bad fats, high amounts or unbalanced ratios of omega-6 to omega-3s has been linked to a range of health problems, from cardiovascular disease, to cancer and other illnesses. High consumption of omega 3s, on the other hand, is linked to reduced risks of a number of diseases, including diabetes, high blood pressure, high cholesterol, cancer, and many other chronic disorders. The diet of early humans maintained a ratio of 1, but modern Western food production, with its focus on processed and hydrogenated fats, has raised that ratio to an average of 15.

Looking at over 1,600 milk samples over a 3-year span, results found ratios of omega-6 to omega-3 to be .95 for 100% grassfed milk, 2.28 for organic milk, and 5.77 in conventional milk ...continue reading "Differences Between Grass-Fed Organic, Organic, and Conventional Milk"

The results of a recent study in the United Kingdom are in line with what a number of researchers (here, here, and here) have been writing about for a while - that studies show that some cancer screening (e.g. for prostate cancer) of people with no symptoms does not save lives.

The UK study randomly assigned men (aged 50 to 69) to get a PSA test one time or to not get a PSA test (the controls). The PSA test measures prostate-specific antigen in the blood, and is typically used to screen for prostate cancer. It is not done routinely in the UK. They found that while more men were diagnosed with prostate cancer in the PSA group, after 10 years there was no statistical difference in death rates between the two groups. As the researchers themselves said, the PSA screening test resulted in "an increase in the detection of low-risk prostate cancer cases" (the ones that wouldn't cause a problem). But not in the aggressive killer cancers.  However, the researchers are now continuing the study to see if there are differences in the 2 groups after an even longer period of time. From Medical Xpress:

One-off PSA screening for prostate cancer does not save lives

Inviting men with no symptoms to a one-off PSA test for prostate cancer does not save lives according to results from the largest ever prostate cancer trial conducted over 10 years by Cancer Research UK-funded scientists and published today (Tuesday) in the Journal of the American Medical Association (JAMA). Researchers at the Universities of Bristol and Oxford found that testing asymptomatic men with PSA detects some disease that would be unlikely to cause any harm but also misses some aggressive and lethal prostate cancers.

The CAP Trial, which spanned almost 600 GP practices in the UK and included more than 400,000 men aged 50-69, is the largest trial ever to investigate prostate cancer screening. The trial compared 189,386 men who were invited to have a one-off PSA test with 219,439 men who were not invited for screening. After an average of 10 years follow up, there were 8,054 (4.3%) prostate cancers in the screened group and 7,853 (3.6%) cases in the control group. Crucially, both groups had the same percentage of men dying from prostate cancer (0.29%).

While some prostate cancers are aggressive and lethal, others are clinically insignificant and will never lead to any harm or death if left undetected. Ideally, aggressive prostate cancers need to be identified and treated as early as possible. But finding a cancer that would never have caused men harm during their lifetime can have a serious impact on quality of life, including the worry of a cancer diagnosis, the possibility of infection following a biopsy and impotence and incontinence following treatment. ... Dr Richard Roope, Cancer Research UK's GP expert, said: "The PSA test is a blunt tool missing the subtleties of the disease and causing men harm.

Once again, a study found an association between a worrisome health problem (intestinal polyps) with a dietary supplement (calcium), but no problems with eating the foods (calcium rich foods). The large multi-center study specifically looked at serrated polyps (SPs) because they are considered precursor lesions for colorectal cancer - that is, that while they are not cancerous, some of them will develop into cancer. Persons invited to join the study had a recent colonoscopy with at least one adenomatous polyp detected and removed, and then were scheduled for another colonoscopy 3 to 5 years later. This was considered a "chemoprevention study" to see if certain supplements help prevent polyps (and thus cancer).

People in different parts of the US were randomly assigned to either receive calcium supplements (1200 mg/day of elemental calcium), vitamin D (1000 IU/day of vitamin D3),  both supplements (calcium supplement plus vitamin D), or neither. Supplement treatment continued for 3 to 5 years and then there was an observational period that was 6 to 10 years after the person first started supplementation. The higher incidence of serrated polyps was a "late effect" (6 to 10 years later) and not seen during the treatment time (the first 3 to 5 years). They found that women and current smokers had higher risks of serrated polyps when exposed to supplemental calcium. Vitamin D alone was not linked with polyps.

Other studies have also found an association between calcium supplements and increased risk of certain health problems, and a lower incidence of polyps with a higher intake of dietary calcium (real food). The researchers said: "Patients with a history of premalignant serrated polyps, especially women and smokers, may wish to avoid vitamin D and calcium supplementation." BOTTOM LINE: General guidelines should be to eat foods, not supplements, to get your nutrients, vitamins, and minerals. There are many studies also at this point that a high fiber diet with lots of fruits, vegetables, whole grains, legumes (beans), nuts, seeds are associated with better intestinal health and fewer polyps (here, here). Another way to view it is: feed your beneficial gut microbes with good, real food. And especially not highly processed junk. From Medical Xpress:

Calcium supplements may boost risk of abnormal bowel growths

Calcium supplements, taken with or without vitamin D, may increase the risk of small growths in the large bowel (colon) called polyps, suggest results from a large US trial published online in the journal Gut. Polyps are small growths in the lower part of the large bowel. They are non-cancerous, but some could eventually turn into cancer if they are not removed. Polyps come in different shapes and sizes, and this study specifically focused on the risk of serrated polyps, which are less common than conventional "adenomatous" polyps, but likely have the same risk of developing into cancer. 

...continue reading "Best to Eat Calcium Rich Foods, Not Calcium Supplements"

...continue reading "Can We Avoid the Endocrine Disruptors Around Us?"

Study after study has found negative health effects from frequent heavy drinking of alcohol, including a number of cancers. On the other hand, light to moderate drinking seems to have some health benefits (here and here). Recently a large study conducted in France found that chronic heavy drinking, which has resulted in alcohol use disorders (alcohol abuse, alcohol dependence, or alcoholism), is the biggest risk factor for developing dementia, especially early onset dementia. Only people with alcohol use disorders which resulted in them being hospitalized were included in the study.

But the surprising thing was that lower levels of "chronic heavy drinking" doesn't seem so much - it's daily consumption of more than 60 grams of pure alcohol  for men, and more than 40 grams of pure alcohol for women. In the United States, a standard drink contains about 14 grams of alcohol - which is a 12 ounce (350 ml) glass of beer, a 5 ounce (150 ml) glass of 12% wine, or a 1.5 ounce (44 ml) glass of spirits. In other words, drinking 3 glasses of wine daily (or more) is heavy drinking for a woman. (Note: The Centers for Disease Control (CDC) views moderate drinking as 1 glass of wine daily for women, and 2 glasses of wine daily for men).  ...continue reading "Heavy Drinking And Risk of Dementia"

Another study finding health benefits from eating yogurt - that men and women with hypertension who eat at least 2 servings or more per week of yogurt were at a lower risk of having a heart attack (myocardial infarction) and stroke. Women also had a lower risk of a revascularization procedure (such as a coronary artery bypass). The strongest association between yogurt consumption and lower risk of cardiovascular disease was among those with higher DASH (Dietary Approaches to Stop Hypertension) diet scores.The DASH diet is considered a healthy diet, one rich in fruits, vegetables, nuts, whole grains, beans (legumes), etc.

The major thing to keep in mind is that high blood pressure is a major cardiovascular disease risk factor. So anything that helps lower risk of heart attack or stroke is good. Note that in this large study they did not randomly assign people to different groups - so the higher yogurt intake people also tended to have a healthier lifestyle. But other studies have had similar findings to this one. For example, eating dairy products regularly is linked to lower rates of cardiovascular disease and high blood pressure, while eating yogurt regularly is linked to lower rates of hypertension and type 2 diabetes.

Also note that the types of yogurt (whole-fat, low-fat, non-fat) eaten were not looked at, as well as the types of probiotics added to yogurts. Some research suggests that beneficial effects are from whole fat dairy products rather than low-fat dairy products - which is different than DASH diet recommendations. From Science Daily:

Eating yogurt may reduce cardiovascular disease risk

A new study in the American Journal of Hypertension, published by Oxford University Press, suggests that higher yogurt intake is associated with lower cardiovascular disease risk among hypertensive men and women. .... High blood pressure affects about one billion people worldwide but may also be a major cause of cardiovascular health problems. Higher dairy consumption has been associated with beneficial effects on cardiovascular disease-related comorbidities such as hypertension, type 2 diabetes, and insulin resistance.

For the current analyses, participants included over 55,000 women (ages 30-55) with high blood pressure from the Nurses' Health Study and 18,000 men (ages 40-75) who participated in the Health Professionals Follow-Up Study.

Higher intakes of yogurt were associated with a 30 percent reduction in risk of myocardial infarction among the Nurses' Health Study women and a 19 percent reduction in the Health Professionals Follow-Up Study men. There were 3,300 and 2,148 total cardiovascular disease cases (myocardial infarction, stroke, and revascularization) in the Nurses' Health Study and the Health Professionals Follow-Up Study, respectively. Higher yogurt intake in women was associated with a 16 percent lower risk of undergoing revascularization.

In both groups, participants consuming more than two servings a week of yogurt had an approximately 20 percent lower risks of major coronary heart disease or stroke during the follow-up period. When revascularization was added to the total cardiovascular disease outcome variable, the risk estimates were reduced for both men and women, but remained significant. Higher yogurt intake in combination with an overall heart-healthy diet was associated with greater reductions in cardiovascular disease risk among hypertensive men and women.  [Original study.]

A new observational study from Taiwan found that having one of eight chronic diseases, such as heart disease or diabetes, or their markers (e.g. high cholesterol levels as a marker for heart disease), also significantly raises the person's odds of developing cancer or dying from cancer. The study estimated that these diseases or markers accounted for about 20% of all new cancers and 39% of all cancer deaths. That's about the risk of 5 lifestyle factors combined (smoking, alcohol consumption, obesity, unhealthy diet, and lack of exercise) contributing to cancer development and death.

The eight chronic diseases and markers were: cardiovascular disease (markers for which include blood pressure, total cholesterol, and heart rate), diabetes, chronic kidney disease (markers for which include proteinuria and glomerular filtration rate), pulmonary disease, and gouty arthritis (for which uric acid is a marker). The higher the chronic disease and marker score, the higher the risk of developing cancer and cancer death (a dose-response). Chronic diseases and markers were associated with a shortened lifespan -  about 13.3 years in men and 15.9 years in women.

But the good news is that regular physical exercise lowers the risk of developing cancer by about 48% and the risk of cancer death by 27%. That's huge!  So physical exercise and activity could be viewed as "cancer prevention" strategies. The researchers pointed out that additional cancer prevention strategies are avoiding smoking (very important), avoiding excessive alcohol consumption, maintaining healthy weight, and a healthy diet. From Science Daily:

Substantial impact of chronic diseases on cancer risk

Several common chronic diseases together account for more than a fifth of new cancer cases and more than a third of cancer deaths, finds a study published by The BMJ today. The findings show that the cancer risks from common chronic diseases, such as heart disease and diabetes, are as important as those from five major lifestyle factors combined.

A team of researchers based in the US and Taiwan therefore set out to investigate the combined effect of eight common chronic diseases or disease markers (for example, high blood pressure as a marker of heart disease) on cancer risk compared with lifestyle factorsThey also explored whether physical activity could reduce the cancer risk associated with chronic diseases and disease markers. The study involved 405,878 men and women in Taiwan with no history of cancer .... underwent a series of medical tests between 1996 and 2007. .... Participants were followed for an average of 8.7 years.

The researchers found that cardiovascular disease markers, diabetes, chronic kidney disease markers, pulmonary disease, and gouty arthritis marker were individually associated with risk of developing cancer or cancer death. Higher chronic disease risk scores based on these diseases or markers were linked with an increased risk of developing cancer and cancer death, with the highest level associated with a more than twofold increase in risk of developing cancer and a fourfold increase in risk of cancer death.

High chronic disease risk scores were also associated with substantial reduction in life span. The highest scores were associated with 13.3 years of life lost in men and 15.9 years of life lost in women. Together, these chronic diseases and markers accounted for more than one fifth of all new cancers and more than one third of all cancer deaths in this study population, which was similar to the contribution of five major lifestyle risk factors combined -- smoking, insufficient physical activity, insufficient fruit and vegetable intake, alcohol consumption, and obesity.

The researchers also found that physical activity was associated with a nearly 40% reduction in the excess risks of cancer and cancer death associated with chronic diseases and markers. [Original study.]