Another recent study found numerous health benefits in persons following an intermittent fasting-like diet for 3 months. It resulted in changes in blood and liver markers indicating a lower risk for several diseases (e.g., diabetes), and it reduced biological age 2.5 years.
Researchers found that following a diet that mimics fasting 5 days, then a normal diet 25 days for 3 monthly cycles improve a number of cardiometabolic risk factors such as reduced insulin resistance and other pre-diabetes markers. It also decreased abdominal fat and liver fat, and improved immune system functioning.
What did they eat during the 5 fasting-like days? They ate plant-based, low-calorie, and low-protein foods such as vegetable-based soups, energy bars, energy drinks, chip snacks, chamomile tea, and a supplement providing high levels of minerals, vitamins, and essential fatty acids. The foods were prepackaged and provided by an outside company to ensure the diet was followed.
But more importantly, the participants didn't really fast the 5 days - they just really cut back on calories, and ate plant-based foods. In other words, this type of diet is much easier to follow than a total fast, especially for several months. After the 5 days, the participants resumed eating their normal diet for the next 25 days.
From Medical Xpress: Fasting-like diet lowers risk factors for disease, reduces biological age in humans: Study
Cycles of a diet that mimics fasting can reduce signs of immune system aging, as well as insulin resistance and liver fat in humans, resulting in a lower biological age, according to a new USC Leonard Davis School of Gerontology-led study.
The study, published in Nature Communications on Feb. 20, adds to the body of evidence supporting the beneficial effects of the fasting-mimicking diet (FMD).
The FMD is a five-day diet high in unsaturated fats and low in overall calories, protein, and carbohydrates and is designed to mimic the effects of a water-only fast while still providing necessary nutrients and making it much easier for people to complete the fast. The diet was developed by the laboratory of USC Leonard Davis School Professor Valter Longo, the senior author of the new study.
In addition, the FMD cycles can lower the risk factors for cancer, diabetes, heart disease and other age-related diseases in humans.
The Longo lab also had previously shown that one or two cycles of the FMD for five days a month increased the health span and lifespan of mice on either a normal or Western diet, but the effects of the FMD on aging and biological age, liver fat, and immune system aging in humans were unknown until now.
The study analyzed the diet's effects in two clinical trial populations, each with men and women between the ages of 18 and 70. Patients who were randomized to the fasting-mimicking diet underwent 3–4 monthly cycles, adhering to the FMD for 5 days, then ate a normal diet for 25 days.
The FMD is comprised of plant-based soups, energy bars, energy drinks, chip snacks, and tea portioned out for 5 days as well as a supplement providing high levels of minerals, vitamins, and essential fatty acids. Patients in the control groups were instructed to eat either a normal or Mediterranean-style diet.
An analysis of blood samples from trial participants showed that patients in the FMD group had lower diabetes risk factors, including less insulin resistance and lower HbA1c results. Magnetic resonance imaging also revealed a decrease in abdominal fat as well as fat within the liver, improvements associated with a reduced risk of metabolic syndrome. In addition, the FMD cycles appeared to increase the lymphoid-to-myeloid ratio—an indicator of a more youthful immune system.
Further statistical analysis of the results from both clinical studies showed that FMD participants had reduced their biological age—a measure of how well one's cells and tissues are functioning, as opposed to chronological age—by 2.5 years on average.