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Brain aging can be viewed as having 2 parts: chronological age (normally  the brain grey matter volume slowly shrinks with advancing age) and a lifetime of exposures - which can be negative from unhealthy lifestyle and injuries, and positive from a healthy lifestyle and enriched environments. That's why after a lifetime there can be wide variation in the physiological age of our brains. These differences in the  brain (in the grey matter) can be measured with magnetic resonance imaging (MRIs).

The researchers in this study used the concept of physiological age - the difference between the chronological age and predicted age, as a marker of brain health. They looked at adults of varying ages,and found that the more flights of stairs a person climbs daily, and the more years of school a person had completed, the "younger" their brain physically appears.  This study was a cross-sectional study and so shows an association rather than a definite cause, but interestingly other forms of exercise did not show this link (walking/hiking, jogging, running, bicycling, aerobic exercise, lap swimming, tennis.squash/racquetball, low intensity exercise). From Science Daily:

Want a younger brain? Stay in school -- and take the stairs

Taking the stairs is normally associated with keeping your body strong and healthy. But new research shows that it improves your brain's health too -- and that education also has a positive effect. In a study recently published in the journal Neurobiology of Aging, researchers led by Jason Steffener, a scientist at Concordia University's Montreal-based PERFORM Centre, show that the more flights of stairs a person climbs, and the more years of school a person completes, the "younger" their brain physically appears.

The researchers found that brain age decreases by 0.95 years for each year of education, and by 0.58 years for every daily flight of stairs climbed -- i.e., the stairs between two consecutive floors in a building.

For the study, Steffener and his co-authors used magnetic resonance imaging (MRI) to non-invasively examine the brains of 331 healthy adults who ranged in age from 19 to 79. They measured the volume of grey matter found in participants' brains because its decline, caused by neural shrinkage and neuronal loss, is a very visible part of the chronological aging process. Then, they compared brain volume to the participants' reported number of flights of stairs climbed, and years of schooling completed. 

Results were clear: the more flights of stairs climbed, and the more years of schooling completed, the younger the brain. "This study shows that education and physical activity affect the difference between a physiological prediction of age and chronological age, and that people can actively do something to help their brains stay young," he says.

Another positive thing we can do for our brains - meditation.From Science Daily:

Forever young: Meditation might slow the age-related loss of gray matter in the brain

Since 1970, life expectancy around the world has risen dramatically, with people living more than 10 years longer. That's the good news.The bad news is that starting when people are in their mid-to-late-20s, the brain begins to wither -- its volume and weight begin to decrease. As this occurs, the brain can begin to lose some of its functional abilities.

Building on their earlier work that suggested people who meditate have less age-related atrophy in the brain's white matter, a new study by UCLA researchers found that meditation appeared to help preserve the brain's gray matter, the tissue that contains neurons.

The scientists looked specifically at the association between age and gray matter. They compared 50 people who had mediated for years and 50 who didn't. People in both groups showed a loss of gray matter as they aged. But the researchers found among those who meditated, the volume of gray matter did not decline as much as it did among those who didn't.

Dr. Florian Kurth, a co-author of the study and postdoctoral fellow at the UCLA Brain Mapping Center, said the researchers were surprised by the magnitude of the difference."We expected rather small and distinct effects located in some of the regions that had previously been associated with meditating," he said. "Instead, what we actually observed was a widespread effect of meditation that encompassed regions throughout the entire brain."

As baby boomers have aged and the elderly population has grown, the incidence of cognitive decline and dementia has increased substantially as the brain ages.

Each group in the study was made up of 28 men and 22 women ranging in age from 24 to 77. Those who meditated had been doing so for four to 46 years, with an average of 20 years.

The participants' brains were scanned using high-resolution magnetic resonance imaging. Although the researchers found a negative correlation between gray matter and age in both groups of people -- suggesting a loss of brain tissue with increasing age -- they also found that large parts of the gray matter in the brains of those who meditated seemed to be better preserved, Kurth said.

The researchers cautioned that they cannot draw a direct, causal connection between meditation and preserving gray matter in the brain. Too many other factors may come into play, including lifestyle choices, personality traits, and genetic brain differences.