weight loss drugs – Lacto Bacto

It looks like another health problem has popped up with some of the weight loss drugs so many women of reproductive age are now taking. This time menstrual related events, including heavy menstrual bleeding, blood clots, and frequency of menstrual bleeding.

Researchers looked at data in the FDA Adverse Event Reporting System for 3 weight loss drugs (Semaglutide, Tirzepatide, and Liraglutide), which are glucagon-like peptide-1 receptor agonists. They found that females aged 12 to 55 years (reproductive age) reported problems with 2 of the weight-loss drugs. Semaglutide had the most adverse reports: heavy menstrual bleeding, intermenstrual bleeding, menstrual clots, infrequent menstrual periods (oligomenorrhea), and cycles without ovulation (anovulatory cycles). Tirzepatide had reports of intermenstrual bleeding and menstrual clots, and Liraglutide had by far the fewest adverse reports ("produced no significant signals").

From Medscape: Menstrual Clots and Heavy Bleeding Linked to Popular Weight-Loss Drugs

GLP-1 receptor agonists (RAs), particularly semaglutide, are associated with disproportionate reporting of menstrual adverse events including heavy bleeding, intermenstrual bleeding, and menstrual clots in reproductive-aged female patients. Tirzepatide showed signals for intermenstrual bleeding and menstrual clots. ...continue reading "Some Weight Loss Drugs Can Result In Menstrual Related Problems"

Weight loss drugs (e.g., Ozempic) are very, very popular these days. But what happens when you stop taking the prescription drugs? A recent review of 11 global studies found that the drugs work well while being used, and led to significant weight loss. But within 2 months of stopping the medications, significant regaining of weight starts.

The researchers noted that the studies found that regaining of weight started by 8 weeks after the medications were stopped, and that weight gains tended to plateau about 20 weeks later, but continued as long as the studies lasted (even 1 year later). Yikes!

From Science Daily: What really happens to your body when you stop weight loss drugs like Ozempic

Patients prescribed drugs to help them lose weight may experience a rebound in weight gain after halting their prescription, finds a meta-analysis published in BMC Medicine. The study, which analyses data for patients receiving weight loss drugs across 11 randomised trials, suggests that while the amount of weight regain varies depending on the specific drug, there is a broad trend in associated weight regain after the course of medication concluded. ...continue reading "Effects of Stopping Weight Loss Drugs"