There has been a lot of discussion recently about whether older adults form new neurons in the brain. Neurons are specialized cells transmitting nerve impulses in the brain - they are nerve cells. In other words, if elderly people form new neurons in the brain, then this is excellent news for brain function. This means we can look for ways to enhance neurogenesis (formation of new neurons) and slow or prevent cognitive decline, whether in diseases such as Alzheimer's or normal age-related cognitive declines. Because yes, it is normal to have age-related declines, but some people have more declines while others far, far less.
Researchers at the University of Illinois at Chicago studied the hippocampus of 18 elderly brains (mean age 90.6 years!) after death (post-mortem). They found both new neural stem cells (neural progenitor cells) and developing neurons in each person's brain, but the numbers varied a lot between the brains. For example, brains with evidence of Alzheimer's disease and cognitive impairments had significantly fewer developing neurons than those without cognitive declines.
These results go hand in hand with studies showing a number of known age related brain changes, such as the volume of the brain shrinking a little as we age (this is considered normal). Studies find that there are ways to slow down this shrinkage such as good nutrition (including nuts, fruits and vegetables, coffee or tea containing caffeine, eating seafood), physical activity, exercise, having mentally stimulating activities. Also, avoiding medicines with anticholinergics, and avoiding air pollution and an unhealthy Western style diet (highly processed foods, low fiber, lots of meat).
In a new study from the University of Illinois at Chicago, researchers examining post-mortem brain tissue from people ages 79 to 99 found that new neurons continue to form well into old age. The study provides evidence that this occurs even in people with cognitive impairment and Alzheimer's disease, although neurogenesis is significantly reduced in these people compared to older adults with normal cognitive functioning.
The idea that new neurons continue to form into middle age, let alone past adolescence, is controversial, as previous studies have shown conflicting results. The UIC study is the first to find evidence of significant numbers of neural stem cells and newly developing neurons present in the hippocampal tissue of older adults, including those with disorders that affect the hippocampus, which is involved in the formation of memories and in learning.
"We found that there was active neurogenesis in the hippocampus of older adults well into their 90s," said Orly Lazarov, professor of anatomy and cell biology in the UIC College of Medicine and lead author of the paper. "The interesting thing is that we also saw some new neurons in the brains of people with Alzheimer's disease and cognitive impairment." She also found that people who scored better on measures of cognitive function had more newly developing neurons in the hippocampus compared to those who scored lower on these tests, regardless of levels of brain pathology.
Lazarov thinks that lower levels of neurogenesis in the hippocampus are associated with symptoms of cognitive decline and reduced synaptic plasticity rather than with the degree of pathology in the brain. For patients with Alzheimer's disease, pathological hallmarks include deposits of neurotoxic proteins in the brain.
"In brains from people with no cognitive decline who scored well on tests of cognitive function, these people tended to have higher levels of new neural development at the time of their death, regardless of their level of pathology," Lazarov said. "The mix of the effects of pathology and neurogenesis is complex and we don't understand exactly how the two interconnect, but there is clearly a lot of variation from individual to individual." Lazarov is excited about the therapeutic possibilities of her findings.
Lazarov and colleagues looked at post-mortem hippocampal tissue from 18 people with an average age of 90.6 years. They stained the tissue for neural stem cells and also for newly developing neurons. They found, on average, approximately 2,000 neural progenitor cells per brain. They also found an average of 150,000 developing neurons. Analysis of a subset of these developing neurons revealed that the number of proliferating developing neurons is significantly lower in people with cognitive impairment and Alzheimer's disease.
Lazarov is interested in finding out whether the new neurons she and her team discovered in the brains of older adults are behaving the way new neurons do in younger brains.