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Exposure To Sunlight Improves Gut Microbes and Vitamin D Levels

Researchers in Canada found that sunlight (or UVB light) on the skin changes the gut microbes (gut microbiome), especially in people with lower levels of vitamin D, that is, who are vitamin D deficient. UVB (Ultraviolet B light) exposure increased beneficial gut microbe diversity and richness in these people, as well as increasing their vitamin D levels. However, people who had been taking vitamin D supplements prior to the study, and who had sufficient vitamin D levels, did not have significant gut microbiome changes.

The researchers viewed the study results as evidence that there may be a skin-gut axis. As the researcher Vallance said: “It is likely that exposure to UVB light somehow alters the immune system in the skin initially, then more systemically, which in turn affects how favorable the intestinal environment is for the different bacteria,” suggested Vallance.

The researchers also thought that these study results (which was conducted in Vancouver, Canada, in healthy human volunteers) could help explain the protective effect of UVB light against inflammatory diseases such as multiple sclerosis (MS) or inflammatory bowel disease (IBD). And how did the researchers know what bacteria were in the gut in the study participants? They analyzed the feces with modern genetic sequencing methods. By the way, these results match what has been found in earlier studies in humans and mice.

Bottom line: Sunlight on the skin is beneficial to the gut microbiome, by increasing gut bacteria linked to health. In the study the increases in bacteria (after UVB light exposures) were in the Lachnospiraceae, Ruminococcus, and Clostridiaeae families. And nope, none of those are found in currently available probiotics. By the way, this study was conducted in winter in Canada, so the effects of UVB light were clearly seen in the healthy volunteers. This study supports getting some sunlight exposure (on the skin), and perhaps supplementing with vitamin D in the winter.

From Medical Xpress: Where the sun doesn't shine? Skin UV exposure reflected in poop 

The sun can indeed shine out of your backside, suggests research. Not because you're self-absorbed, but because you've absorbed gut-altering UV radiation. This is the first study to show that skin exposure to UVB light alters the gut microbiome in humans. Published in Frontiers in Microbiology, the analysis suggests that vitamin D mediates the change—which could help explain the protective effect of UVB light in inflammatory diseases like MS and IBD.

Sun exposure, vitamin D levels and the mix of bacteria in our gut are each associated with risk of inflammatory conditions like MS and IBD. Scientists hypothesize that a causal chain links the three.

Exposure to UVB in sunlight is well-known to drive vitamin D production in the skin, and recent studies suggest that vitamin D alters the human gut microbiome. However, that UVB therefore causes gut microbiome changes, via vitamin D production, has so far been shown only in rodents.

In a new clinical pilot study, researchers tested the effect of skin UVB exposure on the human gut microbiome.

Healthy female volunteers (n=21) were given three one-minute sessions of full-body UVB exposure in a single week. Before and after treatment, stool samples were taken for analysis of gut bacteria—as well blood samples for vitamin D levels. Skin UVB exposure significantly increased gut microbial diversity, but only in subjects who were not taking vitamin D supplements during the (winter) study (n=12).

"Prior to UVB exposure, these women had a less diverse and balanced gut microbiome than those taking regular vitamin D supplements," reports Prof. Bruce Vallance, who led the University of British Columbia study. "UVB exposure boosted the richness and evenness of their microbiome to levels indistinguishable from the supplemented group, whose microbiome was not significantly changed."

The largest effect was an increase in the relative abundance of Lachnospiraceae bacteria after the UVB light exposures. "Previous studies have linked Lachnospiraceae abundance to host vitamin D status," adds Vallance. "We too found a correlation with blood vitamin D levels, which increased following UVB exposure."

This indicates that vitamin D at least partly mediates UVB-induced gut microbiome changes. The results also showed some agreement with mouse studies using UVB, such as an increase in Firmicutes and decrease in Bacteroidetes in the gut following exposure.

The study is not designed to show the exact mechanism by which the microbiome changes occur, but both UVB and vitamin D are known to influence the immune system.

"It is likely that exposure to UVB light somehow alters the immune system in the skin initially, then more systemically, which in turn affects how favorable the intestinal environment is for the different bacteria," suggests Vallance.

"The results of this study have implications for people who are undergoing UVB phototherapy, and identifies a novel skin-gut axis that may contribute to the protective role of UVB light exposure in inflammatory diseases like MS and IBD."

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