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Tag: invasive breast cancer

Published on Leave a comment on Pesticides and Breast Cancer
Normal (left) vs cancerous breast (right), mammography image
Credit: National Cancer Institute

Many studies link pesticide exposure to the development of various cancers, including breast cancer. We tend to think of pesticide exposure as occurring when there is direct contact with the pesticide - for example during application, or when walking on lawns or areas with freshly applied pesticides. Yet... there are other routes that have been neglected in studies, such as washing pesticide contaminated clothes. 

At a recent webinar (42nd National Forum Series - The Pesticide Threat to Environmental Health), Carolina Panis, PhD, (Ass. Professor of Medicine at Western Paraná State University in Brazil, and Visiting Researcher at Harvard University and the University of Arizona) spoke about pesticide exposure in women and breast cancer.  She discussed her recent research showing that women occupationally exposed to pesticides (e.g., as farm workers) and diagnosed with breast cancer seem to have more aggressive disease, also at younger ages, than unexposed women. An increased mortality rate went along with this.

She also discussed an interesting finding regarding women living in farm areas (with heavy pesticide use) in Brazil. Not only is occupational exposure to pesticides linked to breast cancer, but additionally - women having chronic (daily) exposure are also exposed to pesticide residues when washing clothing used by someone who had applied pesticides. Laundry exposure! Women absorb pesticide residues (e.g., glyphosate, atrazine) from the pesticide contaminated clothing, which increases the amount of pesticides in their bodies and this is also linked to breast cancer.

The women she looked at lived in farming areas, and additionally many had their residences frequently sprayed for insects. Ultimately, women exposed to high levels of pesticides tend to develop metastatic untreatable breast cancer, and at a younger age (unlike other areas where breast cancer is highly treatable). She pointed out that pesticides also have a negative effect on the immune system.

From the article by C. Pannis and B. Lemos: Pesticide Exposure and Increased Breast Cancer Risk In Women Population Studies

Women in rural regions are at risk for exposure to pesticides by equipment decontamination, unprotected clothes washing, pesticide drift, chemical spraying in the field, and other routes of exposure in the household. Pesticides can act on mammary gland cells in direct and indirect ways, augmenting the risk for breast cancer development. ...continue reading "Pesticides and Breast Cancer"

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Again, more research finding that being overweight or obese is associated with an increased risk of breast cancer - specifically higher risk of invasive breast cancer in postmenopausal women. They found that the heavier the woman, the higher the risk, but the risk did not vary with hormone therapy use or race and ethnicity. From Medical Xpress:

Obesity associated with increased breast cancer risk in postmenopausal women

An analysis of extended follow-up data from the Women's Health Initiative clinical trials suggests that postmenopausal women who were overweight and obese had an increased risk of invasive breast cancer compared to women of normal weight, according to an article published online by JAMA Oncology. Obesity is a major public health problem in the United States and obesity has been associated with breast cancer risk in observational studies, systematic reviews and meta-analyses.

The Women's Health Initiative (WHI) protocol measured height and weight, baseline and annual or biennial mammograms, and breast cancer in 67,142 postmenopausal women enrolled from 1993 to 1998 with a median of 13 years of follow-up. There were 3,388 invasive breast cancers. Analysis by the authors found:

  • Women who were overweight (body mass index [BMI] 25 to < 30); obese, grade 1 (BMI 30 to < 35); and obese, grade 2 plus 3 (BMI > 35) had an increased risk of invasive breast cancer compared to women of normal weight (BMI < 25)
  • The risk was greatest for women with a BMI greater than 35; those women had a 58 percent increased risk of invasive breast cancer compared with women of normal weight (BMI < 25)....
  • Obesity was associated with markers of poor prognosis; women with a BMI greater than 35 were more likely to have large tumors, evidence of lymph node involvement and poorly differentiated tumors
  • Women with a baseline BMI of less than 25 who gained more than 5 percent of body weight during the follow-up period had an increased risk of breast cancer....

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Women: if you sit at work all day, and then you sit 6 or more hours during your leisure time, then you are at significantly greater risk of developing any cancer (compared to women who sit for fewer than 3 hours a day during leisure time). And the odds for certain cancers (multiple myeloma, ovarian cancer, and invasive breast cancer) are greatly increased. That 30 minutes at the gym doesn't cancel out the negative effects of sitting all day. But interestingly, this pattern didn't apply to men. From Medscape:

Leisure Time Sitting Increases Cancer Risk in Women

Women who sit 6 or more hours a day during their leisure time have a 10% greater risk of developing any cancer compared with women who sit for fewer than 3 hours a day. In addition, they are more likely to develop certain site-specific cancers, such as invasive breast cancer, ovarian cancer, and multiple myeloma. However, no similar pattern emerged for men.

"So when we think about independent risk factors for many types of cancer, and definitely for invasive breast cancer, you want to tell women to maintain a physically active lifestyle, to maintain a healthy weight, to limit their alcohol consumption, and now you also want to tell them to reduce their time spent sitting," she said.

The findings come from an analysis of data on some 69,260 men and 77,462 women enrolled in the American Cancer Society Cancer Prevention Study II Nutrition. All participants were cancer-free on enrolment. Between 1992 and 2009, 18,555 men and 12,236 women were diagnosed with cancer. On average, men were followed for 13.2 years, and women were followed for an average of 15.8 years.

"In women, leisure-time spent sitting was associated with a statistically significant higher risk of total cancer incidence...after adjustment for physical activity, [body mass index (BMI)], and other potential confounders," the authors report. Sitting 6 or more hours a day during leisure time was also associated with a 65% greater risk for multiple myeloma, a 43% greater risk for ovarian cancer, and a 10% greater risk for invasive breast cancer compared with women who sat less than 3 hours a day during leisure time. The association between longer sitting times and endometrial cancer was statistically significant before adjusting for BMI, but was attenuated when adjusted for BMI.

The same pattern was not seen in men in this study. Leisure time spent sitting was not associated with cancer risk in men, with the exception of an 11% higher risk associated with sitting time among obese men.

"There are a lot of individuals whom I would describe as 'an active couch potato.' " Dr Patel said. "People are going to the gym and maintaining a healthy weight, but they spend the majority of the rest of their time in sedentary activities — sitting at work, sitting in the car, sitting at home — so you really have to think not just of that 30 minutes a day where you are intentionally engaging in physical activity, but what does the rest of your day look like?"