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Tag: primary open-angle glaucoma (POAG)

Published on Leave a comment on Study Finds Vitamin B3 Supplements Lower the Risk of Developing Glaucoma
Human eye Credit: Wikipedia

A recent large study found that vitamin B3 (nicotinamide) supplements may help in preventing glaucoma (specifically primary open-angle glaucoma) and also need fewer treatments (e.g., eye drops and laser procedures) in those with glaucoma.

Glaucoma refers to many diseases involving eye pressure increases and damage to the optic nerve, which can result in permanent vision loss and blindness. Primary open-angle glaucoma (POAG) is the most common form of glaucoma. The study found that those taking nicotinamide supplements had a 66% lower risk of developing glaucoma.

Since the study is behind a paywall, I've included summaries (each a little different) from 2 web-sites describing the study.

From Medical Xpress: Could vitamin B3 prevent silent thief from stealing vision? New study finds protective effects against glaucoma

Often called the silent thief of sight, glaucoma is a group of eye diseases that gradually damage the optic nerve, often without warning signs. It is linked to increased pressure (ocular hypertension) inside the eye and, if left untreated, can lead to permanent vision loss. Even with ongoing treatment, some people still face the risk of progressive vision loss.

This led scientists to look for newer therapeutics that can help manage the disease's progression, such as nicotinamide, a form of vitamin B3. ...continue reading "Study Finds Vitamin B3 Supplements Lower the Risk of Developing Glaucoma"

Published on Leave a comment on Hormone Replacement Therapy Associated With Glaucoma
Human eye Credit: Wikipedia

Vision loss is a serious concern for people as they age. Recent research found that any kind hormone replacement therapy (HRT) used by postmenopausal women is associated with a 36% higher risk of developing glaucoma.

The study was conducted with 6576 Finnish women aged 50 years or older. The researchers also found that the longer a women used HRT, especially estrogen only HRT,  the greater the risk for glaucoma. All 3 types of HRT (estrogen only, progestogen only, or combined estrogen-progestogen) were associated with a higher risk for developing glaucoma:

From Medscape: Postmenopausal HRT Tied to Glaucoma Risk in Women

In Finnish women aged 50 years or older, the use of any postmenopausal hormone replacement therapy (HRT) was linked to a higher risk for developing glaucoma, with estrogen-only therapy specifically associated with the risk for primary open-angle glaucoma. ...continue reading "Hormone Replacement Therapy Associated With Glaucoma"

Published on

This study found that greater intake of dietary nitrate and green leafy vegetables was associated with a 20 percent to 30 percent lower risk of primary open-angle glaucoma (POAG), which is the most common form of glaucoma. Glaucoma can lead to vision loss and even blindness (if left untreated).There is evidence that nitric oxide has a role in primary open-angle glaucoma, and that dietary intake of nitrates is beneficial. Green leafy vegetables (iceberg lettuce, romaine lettuce,  mustard, or chard, cooked spinach, and raw spinach) were found to be most beneficial, as well as kale and collard greens. Those who ate the most green leafy vegetables ate about 1.5 servings per day, versus .3 servings daily in the lowest intake group.

Dietary nitrate is predominately derived from green leafy vegetables, which contribute approximately 80% of nitrate intake. But they are found as well in other vegetables, such as beets and carrots. It should be pointed out that those who consumed the most dietary nitrate in this study also consumed more fruits and vegetables, and so also consumed more dietary carotenoids, vitamin C, vitamin E, flavonoids, folate, and vitamin A. Bottom line: try to eat fruits and vegetables daily, especially green leafy vegetables (e.g., a salad). From Science Daily:

Higher dietary nitrate, green leafy vegetable intake associated with lower risk of glaucoma

Greater intake of dietary nitrate and green leafy vegetables was associated with a 20 percent to 30 percent lower risk of primary open-angle glaucoma, according to a study published online by JAMA Ophthalmology.

Elevated intraocular pressure and impaired autoregulation of optic nerve blood flow are implicated in primary open-angle glaucoma (POAG; optic nerve damage from multiple possible causes that is chronic and progresses over time). Evidence suggests that nitrate or nitrite, precursors for nitric oxide, is beneficial for blood circulation. Jae H. Kang, Sc.D., of Brigham & Women's Hospital and Harvard Medical School, Boston, and colleagues evaluated the association between dietary nitrate intake, derived mainly from green leafy vegetables, and POAG. The researchers followed up participants biennially in the prospective cohorts of the Nurses' Health Study (63,893 women; 1984-2012) and the Health Professionals Follow-up Study (41,094 men; 1986-2012). Eligible participants were 40 years or older, were free of POAG, and reported eye examinations. Information on diet was updated with questionnaires.

During follow-up, 1,483 incident cases of POAG were identified. Participants were divided into quintiles (one of five groups) of dietary nitrate intake (quintile 5, approximately 240 mg/d; quintile 1, approximately 80 mg/d). The researchers found that greater intake of dietary nitrate and green leafy vegetables was associated with a 20 percent to 30 percent lower POAG risk; the association was particularly strong (40 percent-50 percent lower risk) for POAG with early paracentral visual field loss (a subtype of POAG linked to dysfunction in blood flow autoregulation).