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Tag: skin cancer

Published on Leave a comment on Taking Vitamin B3 Reduces the Risk of Another Skin Cancer
Basal cell carcinoma Credit: Wikipedia

Skin cancer (basal cell carcinoma, squamous cell carcinoma, and melanoma) rates are rising. Skin cancer is the most common cancer in the U.S., with current estimates that 1 in 5 Americans will develop skin cancer in their lifetime. Unfortunately, a person can get repeat skin basal cell and squamous cell cancers. Yikes!

Interestingly, since 2015 studies are finding that a form of vitamin B3 called nicotinamide are a skin cancer preventive (chemopreventive) medication. That is, taking nicotinamide supplements reduces the risk of basal cell and squamous cell cancer development.

A recent study found that persons who already had one skin cancer removed, can significantly reduce the risk of a second skin cancer occurring if they ingest 500 mg of nicotinamide two times daily for more than one month. An overall 54% reduction in another skin cancer occurring in this group!

The biggest reduction of another skin cancer occurring was in those who had a squamous cell carcinoma removed. However the preventive effect was reduced in those who already had multiple (2 or more) skin cancers.

Excerpts from NPR: Vitamin B3 can help protect against skin cancer. Here's who may benefit

Doctors who perform skin cancer surgeries often recommend nicotinamide — which is a form of Vitamin B3 — to their patients. It's been shown to protect cells from UV radiation damage. ...continue reading "Taking Vitamin B3 Reduces the Risk of Another Skin Cancer"

Published on Leave a comment on Bariatric Surgery, Weight loss, and Lower Risk of Skin Cancer

Another great reason to lose weight if you are really overweight (let's be honest, the term is "obese") is a lower risk of two types of skin cancer: squamous cell carcinoma and melanoma. Obesity is considered a cancer risk, that is, it increases the risk of cancer, and after bariatric surgery there is a lower risk of cancer.

A long-running study in Sweden (Swedish Obese Subjects study) followed 2 groups of obese individuals for 18 years - 1 group received bariatric surgery (2007 persons) and the other group didn't (2040 persons). They found that the group who had received bariatric surgery, along with a large weight loss, had a significantly lower risk of getting squamous cell carcinoma and melanoma  than the group who received conventional "obesity treatment" (such as advice on losing weight).

How much weight did they lose after the surgery? After 2 years the average weight loss in the surgery group was 63.27 pounds (28.7 kg), which leveled off to 47.62 lbs (47.62 kg) by the 15 year follow-up visit. The weight changes in the non-surgery (control) group was small and never exceeded 6.61 pounds in gains or losses.

The researchers give a number of reasons why a large weight loss may be contributing to reduced risk of skin cancer, including leptin uptake changes, lower chronic systemic inflammation, and changes in gut microbes. In summary, they found a 42% lower risk for both forms of skin cancer combined, and 57% lower risk of malignant melanoma in the surgery group (as compared to the non-surgery group).

BOTTOM LINE: If you are really overweight, then try, try, try to lose a big chunk of weight. Your body will thank you in many ways. Not just lower risk of some cancers (including breast cancer), lower risk of diabetes, increased chance of diabetes reversal, lower risk of dementia, lower chronic systemic inflammation, better sperm quality, and on and on.

The CDC says that a person with a BMI (Body Mass Index) of 30.0 or higher is obese, and being overweight is a BMI of 25 to less than 30. [Body Mass Index table]

From Medical Xpress: Lower risk for malignant melanoma after bariatric surgery   ...continue reading "Bariatric Surgery, Weight loss, and Lower Risk of Skin Cancer"

Published on Leave a comment on Are We Looking At Sunlight and Health the Wrong Way?

Are we looking at vitamin D and sunlight the wrong way? Back in 2016 I posted about the results of a long-running Swedish study that made me rethink everything I knew about sunlight and health. (The prevailing view of dermatologists at the time and now is: to always use sunscreen if going outdoors in order to lower the risk of skin cancer. In other words, that sunlight is always harmful.)

The Swedish study followed women for 20 years and found that: Women who had more sunlight exposure experienced a lower mortality rate than women who avoided sun exposure. However, they were at an increased risk of skin cancer. But those with more sun exposure lived longer due to a decrease in heart (cardiovascular) disease and other noncancer reasons. And the most surprising finding: Nonsmokers who avoided sun exposure had a similar life expectancy as smokers with the highest sun exposure. In other words: avoidance of sun exposure = cigarette smoking when looking at life expectancy. And the results of sun exposure was dose-dependent, with the more, the better for longer life expectancy.

The researchers suggested that  a person's vitamin D levels might be just a marker of sun exposure, which other studies and articles now also suggest. So while we measure vitamin D levels in studies, maybe we should instead be looking at sunlight exposure.

Since then I read more studies that found other benefits of sunlight exposure, such as sunlight having low levels of "blue light" which energizes T cells. T cells are a type of white blood cell, are part of the immune system, and help protect the body from infection and cellular abnormalities (cancer). An earlier study found that exposing skin to sunlight may help to reduce blood pressure and thus cut the risk of heart attack and stroke.

This year I read the following two nicely written articles about this whole issue, both a little different - so worth reading both to get a good idea about the research and the debate.

1) From Outside: Is Sunscreen the New Margarine?

2) From Elemental Medium: What If Avoiding the Sun Is Bad for You?

And once again, a link to the 20 year Swedish study, from the Journal of Internal Medicine: Avoidance of sun exposure as a risk factor for major causes of death: a competing risk analysis of the Melanoma in Southern Sweden cohort

Published on Leave a comment on Don’t Feed Melanoma

This study, even though done on mice, reinforces previous research that taking antioxidant supplements are linked to higher rates of cancer or the spread of cancer (metastases). Here it is linked to the spread of metastatic skin cancer. The researchers say that the overall conclusion from the various studies is that antioxidants protect healthy cells from free radicals that can turn them into malignancies, but may also protect a tumor once it has developed. They also suggest that suntan lotions and skin lotions containing vitamin E and beta-carotene may have the same negative effect and are now studying that possibility. However, note that many, many studies find that eating foods does NOT find negative effects, but only beneficial ones for health. The October 5, 2015 post also discussed why supplements containing large doses of antioxidants (such as beta-carotene) don't work, and can even cause harm. Bottom line: Eat fruits and vegetables daily for numerous health benefits, but skip the antioxidant supplements. From Science Daily:

Antioxidants cause malignant melanoma to metastasize faster

Antioxidants can double the rate of melanoma metastasis in mice, new research shows. The results reinforce previous findings that antioxidants hasten the progression of lung cancer. People with cancer or an elevated risk of developing the disease should avoid nutritional supplements that contain antioxidants, the researchers say.

Researchers at Sahlgrenska Academy, University of Gothenburg, demonstrated in January 2014 that antioxidants hastened and aggravated the progression of lung cancer. Mice that were given antioxidants developed additional and more aggressive tumors. Experiments on human lung cancer cells confirmed the results. Given well-established evidence that free radicals can cause cancer, the research community had simply assumed that antioxidants, which destroy them, provide protection against the disease. Found in many nutritional supplements, antioxidants are widely marketed as a means of preventing cancer. Because the lung cancer studies called the collective wisdom into question, they attracted a great deal of attention.

The follow-up studies at Sahlgrenska Academy have now found that antioxidants double the rate of metastasis in malignant melanoma, the most perilous type of skin cancer. Science Translational Medicine published the findings on October 7. "As opposed to the lung cancer studies, the primary melanoma tumor was not affected," Professor Bergö says. "But the antioxidant boosted the ability of the tumor cells to metastasize, an even more serious problem because metastasis is the cause of death in the case of melanoma. The primary tumor is not dangerous per se and is usually removed."

Experiments on cell cultures from patients with malignant melanoma confirmed the new results. "We have demonstrated that antioxidants promote the progression of cancer in at least two different ways," Professor Bergö says. The overall conclusion from the various studies is that antioxidants protect healthy cells from free radicals that can turn them into malignancies but may also protect a tumor once it has developed.

Avoid supplements: Taking nutritional supplements containing antioxidants may unintentionally hasten the progression of a small tumor or premalignant lesion, neither of which is possible to detect. "Previous research at Sahlgrenska Academy has indicated that cancer patients are particularly prone to take supplements containing antioxidants," Dr. Bergö says. Our current research combined with information from large clinical trials with antioxidants suggests that people who have been recently diagnosed with cancer should avoid such supplements."

The role of antioxidants is particularly relevant in the case of melanoma, not only because melanoma cells are known to be sensitive to free radicals but because the cells can be exposed to antioxidants by non-dietary means as well. "Skin and suntan lotions sometimes contain beta carotene or vitamin E, both of which could potentially affect malignant melanoma cells in the same way as antioxidants in nutritional supplements," Professor Bergö says. How antioxidants in lotions affect the course of malignant melanoma is currently being explored. "We are testing whether antioxidants applied directly to malignant melanoma cells in mice hasten the progression of cancer in the same way as their dietary counterparts," Professor Bergö says.