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Physical Activity May Be More Important Than Genes In Longevity

For a long time we thought that our genes determine how long we will live (longevity). A new study says not so fast - how we live is more important than our genes. Specifically, how much physical activity and sedentary time (time spent sitting) both have an effect on whether we die early or later, no matter our genetic make-up.

Researchers found that among older women - having higher weekly amounts of light, moderate, or vigorous physical activity was associated with a lower risk of early death. Having higher amounts of sedentary (sitting) time was associated with a higher risk of early death. It didn't matter if there was a genetic predisposition for longevity or not - the findings applied to everyone.

Bottom line: Get off the sofa or out of your chair and move, move, move. All types of physical activity are good for longevity and to lower risk of disease. While this study looked at older women, the findings are also thought to apply to older men.

From Science Daily: Physical activity may have a stronger role than genes in longevity

Previous research has shown that low physical activity and greater time spent sitting are associated with a higher risk of death. Does risk change if a person is genetically predisposed to live a long life?

That is the question researchers at the Herbert Wertheim School of Public Health and Human Longevity Science at University of California San Diego set out to answer in a study published in the August 24, 2022 online edition of the Journal of Aging and Physical Activity.

"The goal of this research was to understand whether associations between physical activity and sedentary time with death varied based on different levels of genetic predisposition for longevity," said lead author Alexander Posis, M.P.H., a fourth-year doctoral student in the San Diego State University/UC San Diego Joint Doctoral Program in Public Health.

In 2012, as part of the Women's Health Initiative Objective Physical Activity and Cardiovascular Health study (OPACH), researchers began measuring the physical activity of 5,446 women in the United States who were 63 and older, following them through 2020 to determine mortality. Participants wore a research-grade accelerometer for up to seven days to measure how much time they spent moving, the intensity of physical activity, and sedentary time.

The prospective study found that higher levels of light physical activity and moderate-to-vigorous physical activity were associated with lower risk of death. Higher sedentary time was associated with higher risk of mortality. These associations were consistent among women who had different levels of genetic predisposition for longevity.

"Our study showed that, even if you aren't likely to live long based on your genes, you can still extend your lifespan by engaging in positive lifestyle behaviors such as regular exercise and sitting less," said senior author Aladdin H. Shadyab, Ph.D., assistant professor at the Herbert Wertheim School of Public Health and Human Longevity Science at UC San Diego. "Conversely, even if your genes predispose you to a long life, remaining physically active is still important to achieve longevity."

Given the aging adult population in the United States, and longer time spent engaging in lower intensity activities, the study findings support recommendations that older women should participate in physical activity of any intensity to reduce the risk of disease and premature death, wrote the authors.

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