A recent study found that giving daily vitamin D supplements to children with severe asthma and low vitamin D levels did not prevent severe asthma attacks, reduce the time to an asthmatic attack, or enable the children to reduce the maintenance dose of an inhaled corticosteroid. Very disappointing!
As of 2018, it is estimated that 5.5 million children in the US have asthma, and that asthma led to more than 546,000 emergency department visits and 80,000 hospitalizations. So the researchers started the study hoping that vitamin D3 supplements could help with asthma attacks.
The well-done year long study recruited children (6 to 16 years old) from 7 US medical centers. They were assigned randomly to different groups (vitamin D or placebo), and with no one knowing who got vitamin D and who didn't. The children took 4000 IU/day of vitamin D3 or a placebo for 48 weeks, and all were maintained with a low-dose of inhaled corticosteroid (fluticasone propionate).
The findings contrast with earlier observational studies (basically a snap-shot of groups of people) that found a link with severe asthma and lower vitamin D levels. Meanwhile, other well-done studies (women assigned randomly to different groups, etc) have found no protective effect from vitamin D3 supplementation during pregnancy - that is, it did not protect children up to the age of 6 from asthma.
Excerpts from Science Daily: Compared to placebo, vitamin D has no benefit for severe asthma attacks, study finds
Contrary to earlier results, vitamin D supplements do not prevent severe asthma attacks in at-risk children, according to the first placebo-controlled clinical trial to test this relationship. ...continue reading "Children With Severe Asthma Not Helped By Vitamin D Supplements"