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Published on Leave a comment on Treating Adult Peanut Allergies With Tiny Daily Doses of Peanuts
Peanuts Credit: Wikipedia

Finally some good news for adults with peanut allergies. For a while now it has been known that peanut allergies in young children can be treated with oral immunotherapy (using very tiny doses of peanut protein). But what about adults?

The Phase 2 Trial in adults (average age 24.2 years) with peanut allergies also found good results - by the end they could consume the equivalent of more than 4 peanuts without reacting.

The Grown Up Peanut Immunotherapy (GUPI) trial consisted of 21 adults who ingested tiny doses of peanut protein (peanut flour) taken under strict supervision - with slight increases of peanut protein every 2 weeks until reaching a maintenance dose of 1000 mg (4 large peanuts). 67% of the participants reached the maintenance goal, but 3 adults withdrew from the study due to adverse reactions, and another 3 for unrelated reasons. The 67% also tolerated well a final challenge equivalent to 12 peanuts.

Doing this under supervision was important because when the peanut doses were increased, there initially were side effects. It was also important that daily doses weren't skipped.

In other words, it appears that oral peanut immunotherapy might be an effective treatment for many (most?) adults with peanut allergies. The same researchers will now continue the next phase of clinical trials. Stay tuned...

From Medical Xpress: Daily doses of peanuts tackle allergic reactions in adults, Phase II trial shows

The first clinical trial to test whether adults allergic to peanuts can be desensitized has shown great success with two thirds of the cohort consuming the equivalent of five peanuts without reacting. ...continue reading "Treating Adult Peanut Allergies With Tiny Daily Doses of Peanuts"

Published on Leave a comment on Adding Herbs and Spices To Your Foods Improves Gut Microbiome
Thyme Credit: Wikipedia

It turns out that even making minor adjustments to your usual diet can improve the gut microbiome (the community of bacteria, fungi, viruses living in the gut) within a few weeks. Two separate studies found that eating some peanuts daily or adding some herbs or spices to the  foods you eat can improve the numbers of beneficial bacteria living in the gut.

In the peanut study - eating or not eating peanuts didn't change the diversity or main types of bacteria living in the gut. But eating peanuts did increase the numbers of several beneficial species --Roseburia and Ruminococcaceae, which are butyrate producing bacteria (good!). The peanut group ate 28 grams of peanuts (1 ounce or about 33 peanuts) as a night-time snack for 6 weeks.

In the spice and herb study, adding a combination of spices and herbs to the diet for 4 weeks increased microbial diversity in the gut (good!), and also increased beneficial Ruminococcaceae numbers (good!) in persons at risk for heart disease. Faecalibacterium and Agathobacter  numbers also increased (good!). A variety of dried spices and herbs (1/8 tsp, 3/4 tsp. or 1/1/2 tsp) were added to foods in the daily diet, and not taken as a capsule.

Dried spices added to foods in the spice and herb study included coriander, cumin, allspice, cinnamon, oregano, thyme, onion powder, garlic, ginger, rosemary, thyme, basil, black pepper, paprika, parsley, red pepper, etc. - 24 in all!

Bottom line: These studies agree with other research finding that eating peanuts (and all sorts of nuts, legumes), as well as adding spices and herbs to your foods is beneficial to the gut microbiome. They feed beneficial microbes in your gut, have all sorts of micronutrients, and they also have multitudes of microbes. A win-win.

From Science Daily: Peanuts and herbs and spices may positively impact gut microbiome

Adding a daily ounce of peanuts or about a teaspoon of herbs and spices to your diet may affect the composition of gut bacteria, an indicator of overall health, according to new research from Penn State. In two separate studies, nutritional scientists studied the effects of small changes to the average American diet and found improvements to the gut microbiome. ...continue reading "Adding Herbs and Spices To Your Foods Improves Gut Microbiome"

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Published on 1 Comment on Preventing and Treating Peanut Allergies In Children

Peanut allergies can be life-altering and life-threatening. But in the past year there have been welcome developments in both preventing peanut allergies and in treatment of peanut allergies in children.

The latest medical advice to prevent peanut allergy is to regularly feed tiny amounts of pureed peanut products to babies before their first birthday. Even as early as the 4th month! This is the total opposite of the old advice for preventing peanut allergies, which was to avoid, avoid, avoid giving peanut products to babies.  Oops.

Experts say this method of early introduction, and frequent feeding of small amounts of the food to babies, works best for preventing the development of peanut and egg allergies. [But even with this method, some will eventually develop the food allergies.]

What is a "small amount" of peanuts that should be fed the baby? Guidelines are: "Eight grams of peanut butter (1 heaped teaspoon or 1.5 regular teaspoon) or 17 g of peanut puffs should be consumed at least twice weekly to protect against peanut allergy." However, note that this intervention does not treat peanut allergy. Instead, it is a way to try to prevent a peanut allergy from developing in young children.

But what about older children who already have peanut allergies? What can be done? The US Food and Drug Administration (FDA) recently approved the first ever oral immunotherapy to treat peanut allergies in children between the ages of 4 to 17 years. However, the goal of the therapy is to make children less sensitive and to decrease their allergic reactions. They are still allergic, but less so. For example, after 1 year of treatment - about 2/3 of the kids were able to tolerate 600 mg of peanut protein. Unfortunately, the other third could not.

But here too, continued exposure is important. Researchers found that after 1 year, those who could tolerate the peanut protein have to continue ingesting tiny amounts of peanut. If they stop - the children will lose their tolerance within 2 months.

Treating peanut allergies. From March 2, 2020 article in Medscape: Treating Peanut Allergy With Oral Immunotherapy: Insights From an Insider

Preventing peanut allergies. From August 28, 2019 article in Medscape (the medical site): Pureed Peanuts Advised for Infants to Stave Off Allergy

Feeding pureed peanut products regularly to babies before their first birthday could reduce their risk of developing peanut allergies later on, doctors advise.  ...continue reading "Preventing and Treating Peanut Allergies In Children"

Published on

To celebrate National Nut Day, two articles about health benefits of nuts. From Medical Daily:

National Nut Day 2014: Peanuts, Tree Nuts, And How Each Helps Your Health

“For people who already eat plenty of meat and dairy products…nuts and ‘nutty’ legumes, like Brazil nuts, cashews, peanuts and walnuts, are a good nutritional alternative to meat,” Dr. Donal Murphy-Bokern, independent agri-environmental scientist and author of several studies on food system impacts, said in a statement. Heeding this advice means people can reap the benefits that come with eating nuts — Protein! Fiber! Omega-3 fatty acids! 

Nuts fall into two categories: peanuts (which are really legumes) and tree nuts. The latter includes Brazil nuts, cashews, hazelnuts, macadamias, pecans, pine nuts, pistachios, walnuts and America’s beloved almonds. ...” And existing research generalizes that eating nuts does everything from reduce risk for a slew of diseases, maintains weight, boosts gastrointestinal and bone health, even adds years to a person’s life.

As previously mentioned, nuts are pretty much equal in terms of calories. There are, however, some nuts that have more heart-healthy nutrients and fats than others. See: pistachios. This particular tree nut is high in healthy fats called monounsaturated fats (MUFA). MUFAs are often associated with belly fat.

One study published in the journal Nutrition found that when middle-aged adults at risk for heart disease and diabetes incorporated more pistachios into their diet, they weighed less and lessened their cholesterol and blood sugar levels after just six months. And a separate study from UCLA found people who regularly ate pistachios lost an average of 10 to 12 pounds. Almonds and cashews are additional nuts high in MUFAs. 

The Harvard School of Public Health reported, “several of the largest cohort studies, including the Adventist Study, the Iowa Women’s Health Study, the Nurses’ Health Study, and the Physicians’ Health Study have shown a consistent 30 percent to 50 percent lower risk of myocardial infarction, sudden cardiac death, or cardiovascular disease associated with eating nuts several times a week.”

Though almonds tend to be associated most with heart health, it’s actually walnuts that take the number one spot. ...Health reported a 2006 Spanish study, which “suggested that walnuts were as effective as olive oil at reducing inflammation and oxidation in the arteries after eating a fatty meal.”

Folate, as defined by Harvard Medical School, is “the naturally occurring form of the vitamin that is in foods or in the blood.” It’s also the vitamin that staves off brain atrophy, or the progressive loss of brain cells over time... A study published in the American Journal of Psychiatry found folate may ward off depression, too. And which nut is super rich in folate? Unsalted peanuts...peanuts are also high in vitamin E and niacin, both of which boost brain health. Hazelnuts and almonds are known to have concentrated amounts of E, too, so either nut is bound to help your noggin.

Study done in mice, but shows benefits of walnuts to brain. From Science Daily:

Fight against Alzheimer's disease: New research on walnuts

A new animal study published in the Journal of Alzheimer's Disease indicates that a diet including walnuts may have a beneficial effect in reducing the risk, delaying the onset, slowing the progression of, or preventing Alzheimer's disease. Research led by Abha Chauhan, PhD, head of the Developmental Neuroscience Laboratory at the New York State Institute for Basic Research in Developmental Disabilities (IBR), found significant improvement in learning skills, memory, reducing anxiety, and motor development in mice fed a walnut-enriched diet.

The researchers suggest that the high antioxidant content of walnuts (3.7 mmol/ounce) may have been a contributing factor in protecting the mouse brain from the degeneration typically seen in Alzheimer's disease. Oxidative stress and inflammation are prominent features in this disease, which affects more than five million Americans.

Walnuts have other nutritional benefits as they contain numerous vitamins and minerals and are the only nut that contains a significant source of alpha-linolenic acid (ALA) (2.5 grams per ounce), an omega-3 fatty acid with heart and brain-health benefits. The researchers also suggest that ALA may have played a role in improving the behavioral symptoms seen in the study.