Many people are on statins these days for the purpose of lowering total cholesterol levels and so reducing the risk of heart attack and stroke. But are they still needed past a certain age?
The results of one study conducted in France compared 2 groups of adults 75 years old and older, and who didn't have a history of heart disease or stroke. One group stopped statins and the other continued statin use. They found that in the group of persons stopping statins there was no increase in death rates in the next 3 years, when compared with those still on statins.
There was no difference in heart attacks and strokes among the 2 groups. However, in the group that discontinued statins - their LDL cholesterol levels did rise.
Of course, there will be a lot of debate over these conclusions. And it is unknown if group differences will develop going forward, that is, in the next few years.
From Medical Xpress: Adults 75 and older who stopped statins had similar three-year survival, trial finds
Stopping statins in adults 75 and older with no history of heart disease or stroke does not increase the risk of death over three years compared with continuing statins, although "bad" cholesterol rose around 50% in those who stopped, according to a randomized controlled trial published in The Lancet Healthy Longevity.
Statins are a key medication for the prevention of atherosclerotic cardiovascular disease, a specific type of cardiovascular disease caused by the buildup of fatty plaque (atherosclerosis) inside the arteries.
In 2013, a Cochrane meta-analysis of 18 trials lasting up to five years reported a 14% reduction in deaths from all causes in adults taking statins for primary prevention of atherosclerotic cardiovascular disease with a median age of 57 years. However, most trials looking at statins exclude individuals older than 70 or 80 years; therefore, the benefit of statins for primary prevention of heart disease or stroke in older populations remains unclear.
The new trial enrolled 1,160 adults 75 and older with no history of heart disease or stroke across general practices in France, randomly assigning them to either stop or continue their statin medication.
After three years, 7.2% (35/484) of adults in the statin discontinuation group had died, compared with 7.9% (48/604) in the continuation group. There was no significant difference in major cardiovascular events, including heart attacks and strokes, between those who stopped statins and those who continued over the three years.
However, after three months, there was an average 50% increase (115 mg/dL to 171 mg/dL) in "bad" (LDL) cholesterol among adults who stopped statins, while the group that continued taking statins had no change. Additionally, the study found measures of quality of life, both physical and mental, stayed the same for both groups during the three-year follow-up.
The authors say the benefits of statins increase over time in younger adults, and it remains unknown whether stopping the medication could increase the risk of cardiovascular disease and death after the three-year follow-up period in older people.
They caution that this study does not mean older patients with no history of heart disease or stroke should systematically stop taking their statins—the decision to continue or stop statin treatment in later life should be an individualized, shared decision-making process between patients and clinicians. Further trials are needed to confirm these findings and assess the long-term effect of stopping statins in older adults.