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Tag: chronic wounds

Published on Leave a comment on Could Probiotics Play A Role In Chronic Wound Healing?
Lactobacilli Credit: Wikipedia

Chronic wounds (wounds that won't heal) are a big health problem for many, many people. This past decade has seen all sorts of advances in chronic wound healing treatments, and now there is a future possibility of also applying probiotics on the wounds.

A recent study showed "proof of concept" that some Lactobacillus species are effective in eliminating biofilms and Pseudomonas aeruginosa on skin, which are big problems in chronic wounds. Proof of concept means that a preliminary study using laboratory tests (using "living skin" in a human skin model) showed that it can work, and should be tested further.

The researchers tested a treatment using several species of Lactobacilli (L. acidophilus, L. casei, L. rhamnosus). They found that probiotics added to a modern wound dressing that contained silver did better at eradicating biofilms than using silver containing dressings alone or probiotics alone. (Note: Lactobacillus species are generally viewed as beneficial bacteria, and many Lactobacillus species live at different sites in the human microbiome, which are communities of fungi, bacteria, and viruses.)

The interesting part is that the species picked for the research were because they were in supplements readily available. The researchers cited research showing other Lactobacillus species also having potential in wound treatment, especially due to effects of their lactic acid.

It's an exciting time! Stay tuned to see if probiotic infused dressings actually work on chronic wounds in live human beings...

From Physics News: A living bandage: Wound dressing uses probiotic bacteria to combat biofilms

Millimeter by millimeter, new tissue makes its way through a wound until it has closed a skin lesion. Soon, in the best case, there is nothing left to see of a knee scrape, a finger cut or a burn blister. Not so with chronic wounds, though: If the injury has not healed after four weeks, there is a wound healing disorder. Sometimes, seemingly harmless tissue damage can develop into a permanent health problem or even blood poisoning.

...continue reading "Could Probiotics Play A Role In Chronic Wound Healing?"

Published on Leave a comment on Poor Diets May Lead To Vitamin C Deficiency

  It turns out that scurvy and vitamin C deficiency is still around these days. Scurvy is a disease resulting from a lack of vitamin C. Most animals can synthesize vitamin C, but not humans. We must eat foods containing vitamin C to get the vitamin.

Vitamin C deficiency results in defective formation of collagen and connective tissues (in our bones, skin, tendons, muscles), and symptoms may include weakness, feeling tired, curly hair, sore arms and legs, bruising, bleeding gums, and impaired wound healing.

A recent small Australian study looked at diabetic persons with chronic foot wounds (foot ulcers that didn't heal after several months). Their vitamin C levels were tested and if found to be low, then they were given vitamin C supplements of 500 or 1000 mg daily, and the result was that within 2 to 3 weeks the wounds were healed. The one person with a zinc deficiency was given 50 mg daily of zinc supplement and that wound also promptly healed.

Treatment of scurvy is by taking vitamin C supplements (the Mayo Clinic recommends taking 400 to 1000 milligrams of vitamin C  daily for one week). Vitamin C deficiency can be easily prevented by a diet that includes fruits and vegetables. The recommended daily intake for adult women is 75 milligrams and for adult men it is 90 milligrams, which can be easily met by eating fruits and vegetables, especially if they are fresh (uncooked).

Good sources of vitamin C include: oranges, lemons, kiwi fruit, black currants, papaya, guava, pineapple, mango, strawberries, and vegetables such as bell peppers (red, yellow, green), tomatoes, potatoes, kale, brussels sprouts, and broccoli. It is possible to be vitamin C deficient even if the person is of normal weight or overweight - it all comes down to the diet and whether fruits and vegetables are eaten. Bottom line: Eat some daily!

From Medical Xpress: Poor diet sees scurvy reappear in Australia

Scurvy, a disease historically associated with old-world sailors on long voyages, is making a surprise comeback in Australia, with health officials Tuesday revealing a rare spate of cases. Caused by vitamin C deficiency, the condition used to be a common—and often fatal—curse among seafarers who went months without fresh fruit and vegetables.  ...continue reading "Poor Diets May Lead To Vitamin C Deficiency"

Published on

Now we need ways to nurture our skin bacteria. From Science Daily:

Bacteria on the skin: Our invisible companions influence how quickly wounds heal

A new study suggests microbes living on our skin influence how quickly wounds heal. The findings could lead to new treatments for chronic wounds, which affect 1 in 20 elderly people.

We spend our lives covered head-to-toe in a thin veneer of bacteria. But despite a growing appreciation for the valuable roles our resident microbes play in the digestive tract, little is known about the bacteria that reside in and on our skin. A new study suggests the interplay between our cells and these skin-dwelling microbes could influence how wounds heal.

Chronic wounds -- cuts or lesions that just never seem to heal -- are a significant health problem, particularly among elderly people. An estimated 1 in 20 elderly people live with a chronic wound, which often results from diabetes, poor blood circulation or being confined to bed or a wheelchair."These wounds can literally persist for years, and we simply have no good treatments to help a chronic wound heal," said Hardman, who added that doctors currently have no reliable way to tell whether a wound will heal or persist. 

In their recent study, Hardman and his colleagues compared the skin bacteria from people with chronic wounds that did or did not heal. The results showed markedly different bacterial communities, suggesting there may be a bacterial "signature" of a wound that refuses to heal. "Our data clearly support the idea that one could swab a wound, profile the bacteria that are there and then be able to tell whether the wound is likely to heal quickly or persist, which could impact treatment decisions," said Hardman.

The team also conducted a series of studies in mice to shed light on the reasons why some wounds heal while others do not. They found that mice lacking a single gene had a different array of skin microbiota -- including more harmful bacteria -- and healed much more slowly than mice with a normal copy of the gene. The gene, which has been linked to Crohn's disease, is known to help cells recognize and respond to bacteria. Hardman said the findings suggest that genetic factors influence the makeup of bacteria on a person's skin, which in turn influences how they heal.