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Back in 2015 and 2016 some studies found a link between taking medicines that are anticholinergic and cognitive decline and dementia. Some examples of non-prescription anticholinergic medications are Chlor-Trimeton, Benadryl, Tavist, and Dimetapp. During this time a person also contacted me to report that his relative, who had Down's syndrome, had once participated in a study where he received cholinergic therapy, with the result that during the study he functioned better neurologically. Meanwhile I read several studies of older people that supported the result of a higher intake of foods with choline and better neurological functioning (e.g. verbal and visual memory).

A recent large study of men over a 4 year period found an association between a  higher intake of foods with choline (dietary choline) and better performance on several cognitive tests and lower risk of dementia. The research, which was conducted in Finland, found that the relationship seemed especially strong for a type of choline called phosphatidylcholine. Eggs (specifically the egg yolks) are a primary dietary source of phosphatidylcholine, and indeed, in the study, higher egg intake was associated with better performance on several measures, including verbal fluency, as well as lower risk of dementia.

Choline is an essential nutrient, found in some foods. Its role in the body is complex, but one of its roles is to produce acetylcholine, an important neurotransmitter for memory, mood, muscle control, and other brain and nervous system functions (NIH choline fact sheet). On the other hand, anticholinergic medications block the action of the neurotransmitter acetylcholine (which is involved with learning and memory). Anticholinergic medications include many common drugs, such as some antihistamines, sleeping aids, tricyclic antidepressants, medications to control overactive bladder, and drugs to relieve the symptoms of Parkinson’s disease.

What should one do? First, make sure to eat some foods rich in choline, especially eggs. The researchers themselves say that "consuming an adequate amount of foods high in choline may be an easy, effective, and affordable way to maintain cognitive functioning". Good sources of choline are meat, dairy products, poultry, and eggs - and it appears that eggs (the egg yolks) are especially beneficial. Second, one should also try to avoid non-prescription and prescription medicines known to be anti-cholinergic. For example switch from allergy medicines diphenhydramine or chlorpheniramine (Chlor-Trimeton) to one that isn't anticholinergic. [See list.]

From Science Daily: Dietary choline associates with reduced risk of dementia  ...continue reading "The Choline In Eggs Is Beneficial For the Brain"

Two studies about food and health benefits.  From Science Daily:

Can citrus ward off your risk of stroke?

Eating foods that contain vitamin C may reduce your risk of the most common type of hemorrhagic stroke, according to a study released today that will be presented at the American Academy of Neurology's 66th Annual Meeting in Philadelphia, April 26 to May 3, 2014.

Vitamin C is found in fruits and vegetables such as oranges, papaya, peppers, broccoli and strawberries. Hemorrhagic stroke is less common than ischemic stroke, but is more often deadly.

The study involved 65 people who had experienced an intracerebral hemorrhagic stroke, or a blood vessel rupture inside the brain. They were compared to 65 healthy people. Participants were tested for the levels of vitamin C in their blood. Forty-one percent of cases had normal levels of vitamin C, 45 percent showed depleted levels of vitamin C and 14 percent were considered deficient of the vitamin.

On average, the people who had a stroke had depleted levels of vitamin C, while those who had not had a stroke had normal levels of the vitamin.

"Our results show that vitamin C deficiency should be considered a risk factor for this severe type of stroke, as were high blood pressure, drinking alcohol and being overweight in our study," said study author Stéphane Vannier, MD, with Pontchaillou University Hospital in Rennes, France. "More research is needed to explore specifically how vitamin C may help to reduce stroke risk. For example, the vitamin may regulate blood pressure."

From Science Daily:

Eat spinach or eggs for faster reflexes: Tyrosine helps you stop faster

A child suddenly runs out into the road. Brake!! A driver who has recently eaten spinach or eggs will stop faster, thanks to the amino acid tyrosine found in these and other food products. Leiden cognitive psychologist Lorenza Colzato publishes her findings in the journal Neuropsychologia.

Colzato and her colleagues created a situation in which test candidates had to interrupt a repetitive activity at a given instant. The participants had two sessions in the test lab. On one occasion they were given orange to drink that contained tyrosine, and on the other occasion the orange juice contained a placebo. The tests showed that the candidates performed better on the stopping task if they had drunk the juice with tyrosine.

The positive effect of tyrosine on our reaction speed can have benefits for road safety. But there are many more examples. Colzato: 'Tyrosine food supplements and tyrosine-rich food are a healthy and inexpensive way of improving our intellectual capabilities.

Tyrosine is found in such foods as spinach, eggs, cottage cheese and soya.