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Once again, research shows that "BPA-free" plastic does not mean it is safer than BPA plastic. Both BPA and BPS (the usual replacement for BPA) leach estrogenic chemicals into the foods and beverages, which means negative health effects when ingested. Both BPA and BPS mimic the effects of estrogen, as well as the actions of thyroid hormone. Yes, this study was done on zebrafish, but think of them as "the canaries in the mine" - if it affects them, it could affect humans also, especially developing fetuses and young children.

BPA  and BPS can leach into food, particularly under heat, from the lining of cans and from consumer products such as water bottles, baby bottles, food-storage containers, sippy cups, and plastic tableware. BPA can also be found in contact lenses, eyeglass lenses, compact discs, water-supply pipes, some cash register and ATM receipts, as well as in some dental sealants. A good way to minimize exposure to BPA , BPS, and other estrogenic chemicals is to try to avoid food and beverages in plastic containers and cans, but instead try to buy and store food in glass containers, jars, and bottles. From Science Daily:

'BPA-free' plastic accelerates embryonic development, disrupts reproductive system

Companies advertise "BPA-free" as a safer version of plastic products ranging from water bottles to sippy cups to toys. Many manufacturers stopped used Bisphenol A to strengthen plastic after animal studies linked it to early puberty and a rise in breast and prostate cancers.Yet new UCLA research demonstrates that BPS (Bisphenol S), a common replacement for BPA, speeds up embryonic development and disrupts the reproductive system.

Using a zebrafish model, Wayne and her colleagues found that exposure to low levels of BPA and BPS -- equivalent to the traces found in polluted river waters -- altered the animals' physiology at the embryonic stage in as quickly as 25 hours. "Egg hatching time accelerated, leading to the fish equivalent of premature birth," said Wayne, who is also UCLA's associate vice chancellor for research. "The embryos developed much faster than normal in the presence of BPA or BPS."

The UCLA team, which included first author Wenhui Qiu, a visiting graduate student from Shanghai University, chose to conduct the study in zebrafish because their transparent embryos make it possible to "watch" cell growth as it occurs.... In a second finding, the team discovered that the number of endocrine neurons increased up to 40 percent, suggesting that BPA overstimulates the reproductive system.... "We saw many of these same effects with BPS found in BPA-free products. BPS is not harmless."

After uncovering her first finding about BPA in 2008, Wayne immediately discarded all of the plastic food containers in her home and replaced them with glass. She and her family purchase food and drinks packaged in glass whenever possible. "Our findings are frightening and important," emphasized Wayne. "Consider it the aquatic version of the canary in the coal mine."

Finally, the researchers were surprised to find that both BPA and BPS acted partly through an estrogen system and partly through a thyroid hormone system to exert their effects"Most people think of BPA as mimicking the effects of estrogen. But our work shows that it also mimics the actions of thyroid hormone," said Wayne. "Because of thyroid hormone's important influence on brain development during gestation, our work holds important implications for general embryonic and fetal development, including in humans."

Researchers have proposed that endocrine-disrupting chemicals may be contributing to the U.S.' rise in premature human births and early onset of puberty over the past couple of decades. "Our data support that hypothesis," said Wayne. "If BPA is impacting a wide variety of animal species, then it's likely to be affecting human health. Our study is the latest to help show this with BPA and now with BPS."

More and more negative news about phthalates: men with greater exposure to DEHP (a phthalate) have lower sperm motility (how the sperm move or their ability to swim), and pregnant women with higher levels of phthalates have a higher rate of pregnancy loss (miscarriages - mainly between 5 and 13 weeks of pregnancy). Phthalates are found in many plastics, are thought to be endocrine disruptors, and can be measured in urineFrom Medical Xpress: Lower sperm motility in men exposed to common chemical

Men with higher exposure to the substance DEHP, a so-called phthalate, have lower sperm motility and may therefore experience more difficulties conceiving children, according to a Lund University study. Phthalates is an umbrella term for a group of substances based on phthalic acid, some of which are suspected to be endocrine disruptors. Many phthalates are found in soft plastics in our daily surroundings.... Since phthalate molecules leak out of plastics, we are exposed to it daily and absorb the chemicals through food, drink, skin contact and inhalation. 

"We have studied metabolite levels of the phthalate DEHP (diethylhexyl phthalate) in urine as an indicator of exposure, as well as the semen quality of 300 men between the ages of 18 and 20. The results show that the higher metabolite levels the men had, the lower their sperm motility was", says Jonatan Axelsson, researcher at the Department of Laboratory Medicine, Lund University. For the one quarter of the men with the lowest levels of exposure, 57 per cent of the sperm cells were moving forward, compared to 46 per cent for the quarter of the men with the highest levels of exposure.

As previous research has reported that there is a linear connection also between sperm motility and chances of becoming pregnant, the findings could indicate that the more exposed one is to DEHP, the smaller the chances are of having children.

From Medical Xpress:  Exposure to phthalates could be linked to pregnancy loss

A new study of more than 300 women suggests that exposure to certain phthalates—substances commonly used in food packaging, personal-care and other everyday products—could be associated with miscarriage, mostly between 5 and 13 weeks of pregnancy

Out of concern over the potential health effects of phthalates, the U.S. has banned six of these substances from use in certain products made for young children. But many are still included as ingredients in paints, medical tubes, vinyl flooring, soaps, shampoos and other items. Research on phthalates has shown that long-term exposure to low levels of the some of these compounds harms lab animals' health and can increase their risk for pregnancy loss. Additionally, at least one study found that female factory workers exposed to high levels of phthalates through their work were at a higher risk for miscarriage.

The researchers tested urine samples from 132 women who had miscarriages and 172 healthy pregnant women in China. They found pregnancy loss was associated with higher levels of urinary phthalate metabolites from diethyl phthalate (DEP), di-isobutyl phthalate (DiBP) and di-n-butyl phthalate (DnBP). Although this doesn't prove that phthalates cause pregnancy loss, the study suggests an association exists that the researchers say should be studied further.

When we think about air pollution, we usually think about pollutants in the air that we breathe in. But there is a growing body of evidence that some pollutants found in the air, including a group of chemicals called phthalates, can be absorbed directly through the skin (dermal absorption or dermal intake). A recent study has found that the skin absorption of certain phthalates (DERP and DnBP) is comparable to that from inhalation.

Phthalates are linked to a number of negative health effects, and so we should try to minimize our exposure to them.(Oct. 8, 2015 post and Sept. 29, 2015 post). The findings of this study is another strong argument against using scented products in the home, because phthalates are found in fragrances - whether air fresheners, scented candles, perfumes, dryer sheets, etc. Just think of them as indoor air pollution. From Environmental Health Perspectives:

Transdermal Uptake of Diethyl Phthalate and Di(n-butyl) Phthalate Directly from Air: Experimental Verification

Fundamental considerations indicate that, for certain phthalate esters, dermal absorption from air is an uptake pathway that is comparable to or greater than inhalation. Yet this pathway has not been experimentally evaluated and has been largely overlooked when assessing uptake of phthalate esters.This study investigated transdermal uptake, directly from air, of diethyl phthalate (DEP) and di(n-butyl) phthalate (DnBP) in humans.  ...continue reading "We Are Absorbing Some Air Pollutants Through Our Skin"

Recent research looked at environmental causes of male infertility, specifically endocrine-disrupting chemicals. Poor semen quality contributes to increases in infertility and the use of assisted reproductive technology.The researchers also discuss the higher incidence of testicular cancer worldwide, lower levels of testosterone in men, and poor semen quality among men aged 20 to 25 (with the average man having up to 90% abnormal sperm). From Science Daily:

Endocrine-disrupting chemicals may be threatening fertility in industrialized countries

The birth rate is declining in all industrialised countries, and socioeconomic factors and women's age are not solely to blame. Male reproductive health and environmental factors are also significant, as concluded in a new scientific review article. ...Behind the article are fertility researchers from Denmark, the US and Finland. The researchers studied a number of factors related to fertility, and one of the main conclusions of their study was that poor semen quality contributed to increases in infertility and the use of assisted reproductive technology.

The study also revealed higher incidence of testicular cancer worldwide, with the greatest frequency among Caucasian populations. Moreover, the researchers also observed lower levels of testosterone in average men. "I was surprised that we found such poor semen quality among young men aged 20 to 25. The average man had up to 90% of abnormal sperm. Normally, there would be so many sperms that a few abnormal ones would not affect fertility. However, it appears that we are at a tipping point in industrialised countries where poor semen quality is so widespread that we must suspect that it results in low pregnancy rates," said first author of the article, Professor Niels E. Skakkebaek from the Department of Growth and Reproduction (EDMaRC) at Rigshospitalet and the University of Copenhagen.

"The article also demonstrates the impact of the increasing number of male reproductive problems on low birth rates. There is no doubt that environmental factors are playing a role. These are the correlations we are researching at the new research centre EDMaRC at Rigshospitalet," added Professor Anders Juul, who is the last author of the article.

Many of the male reproductive problems could be due to damage to the testes during embryonic development. While the reproductive problems could arise from genetic changes, "recent evidence suggests that most often they are related to environmental exposures of the fetal testes," the researcher team wrote."Since the disorders in male genitals have increased over a relatively short period of time, genetics alone cannot explain this development. There is no doubt that environmental factors are playing a role and that endocrine-disrupting chemicals, which have the same effect on animals, are under great suspicion. The exposure that young people are subjected to today can determine not only their own, but also their children's, ability to procreate," explained Professor Skakkebaek.

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 Several people have recently asked me whether scented candles have any health effects. The answer is a big YES - they have many negative health effects, and so do other scented products such as air fresheners and dryer sheets (e,g, Bounce). All of them contain fragrances and other chemicals - all from petrochemicals (which means they are chemical products derived from petroleum). And yes - all 3 products are totally unnecessary, so ditch them for better health. View all of them as sources of indoor air pollution.

Most of the candles on the market are made with paraffin wax, derived from petroleum, and scented with synthetic fragrances, also derived from petroleum. Synthetic fragrances typically also contain phthalates that can interfere with your hormone system (endocrine disruptors).

In one study scientists at the South Carolina State University lit several brands of candles made of paraffin – the most common and inexpensive candle wax – as well as soy candles (thus vegetable based) and burned them for 5 to 6 hours in a chamber. All of the candles were unscented and undyed. They found that the paraffin candle smoke emits varying levels of pollutants, including benzene, toluene and ketones, as well as hydrocarbon chemicals called alkanes and alkenes, which are components of gasoline. They have been linked to cancer, asthma and birth defects. None of the vegetable-based soy candles produced toxic chemicals. From SC State University:  Frequent use of certain candles produces unwanted chemicals

Researchers point out that the emissions from burning an occasional paraffin candle will not likely cause health problems - it's the frequent lighting of scented paraffin candles in indoor rooms, and inhaling the pollutants in the air that may cause health problems, or as Dr. Massoudi of S. Carolina State University stated: "could contribute to the development of health risks like cancer, common allergies and even asthma."

Scented candles are known to release various volatile organic compounds (VOCs) including both pleasant aromas and toxic components both before lighting (unlit) and when lit. When lit, the "highest emission concentration" was of formaldehyde. By simply touching the candles, one absorbs chemicals through the skin.

Safe candle alternatives are beeswax candles and unscented soy candles. These do not emit toxic chemicals when burned. However, all burning candles emit soot, which is ultrafine, lung-damaging particulate matter that's capable of penetrating deep into the lungs.

From Huffington Post: The Big Problem With Scented Candles

Scented candles are one of the easiest and most effective ways to mask unpleasant odors in your home....But one of the main problems with scented candles is the scent itself. According to Anne Steinemann, an environmental pollutants expert who is a professor of civil engineering and the chair of sustainable cities at the University of Melbourne, certain candles may emit numerous types of potentially hazardous chemicals, such as benzene and toluene. They can cause damage to the brain, lung and central nervous system, as well as cause developmental difficulties.

"I have heard from numerous people who have asthma that they can’t even go into a store if the store sells scented candles, even if they aren’t being burned," Steinemann added. "They emit so much fragrance that they can trigger asthma attacks and even migraines."

Researchers at South Carolina State University tested both petroleum-based paraffin wax candles and vegetable-based candles that were non-scented, non-pigmented and free of dyes. Their 2009 report concluded that while the vegetable-based candles didn't produce any potentially harmful pollutants, the paraffin candles "released unwanted chemicals into the air," said chemistry professor Ruhullah Massoudi in a statement.

It may be shocking to think that your favorite candles could potentially be bad for you, and made worse by added fragrances. Steinemann said for some people, the effects are "immediate, acute and severe," while others may not realize they are being effected until they gradually develop health issues.

Though the risk to you may be small, there are alternatives. Steinemann suggests going the unscented route, avoiding "even those with essential oils, as they can potentially have hazardous chemicals," she said. "It's almost like air fresheners with the fragrance just sitting there ... permeating surfaces in the room."

Even though many, many personal care products contain parabens, the evidence is accumulating that parabens have negative health effects. And now research suggesting that perhaps they may be a factor in developing breast cancer. This latest study was done "in vitro" - meaning looking at the effects of chemicals on human breast cells (in culture dishes), but the results absolutely should make someone think twice about all the parabens in products, and how they accumulate in us. Research has already found parabens in the human breast, but many thought that the levels were too low to promote cancer.

Parabens are common ingredients in cosmetics, shampoos, body lotions and sunscreens, where they are used to prevent microbial growth and prolong shelf life.  Common names of parabens are: methylparaben, ethylparaben, propylparaben, and butylparaben. Detectable levels of multiple parabens are present in human urine and breast tissue. Bottom line: Parabens are endocrine disrupting chemicals that mimic estrogens and may have effects at very low doses to stimulate breast cancer cell growth. So read labels of personal care products and avoid those with parabens. From Futurity:

New Tests Suggest Parabens Carry Cancer Risk

A group of chemicals called parabens—common ingredients in personal care products—may interact with growth factors in the body to increase the risk of breast cancer, according to new research. Parabens are preservatives widely used in everything from shampoos and cosmetics to body lotions and sunscreens. The chemicals have generated increasing health concerns, however, because they mimic estrogens, which have been linked to an increased risk of breast cancer and reproductive problems.

“Although parabens are known to mimic the growth effects of estrogens on breast cancer cells, some consider their effect too weak to cause harm,” says lead investigator Dale Leitman, a gynecologist and molecular biologist at the University of California, Berkeley, and an adjunct associate professor of nutritional sciences and toxicology. “But this might not be true when parabens are combined with other agents that regulate cell growth.”

Existing chemical safety tests, which measure the effects of chemicals on human cells, look only at parabens in isolation, he says. They fail to take into account that parabens could interact with other types of signaling molecules in the cells to increase breast cancer risk.

To better reflect what goes on in real life, Leitman and his colleagues looked at breast cancer cells expressing two types of receptors: estrogen receptors and HER2. Approximately 25 percent of breast cancers produce an abundance of HER2, or human epidermal growth factor receptor 2. HER2-positive tumors tend to grow and spread more aggressively than other types of breast cancer.

The researchers activated the HER2 receptors in breast cancer cells with a growth factor called heregulin that is naturally made in breast cells, while exposing the cells to parabens. Not only did the parabens trigger the estrogen receptors by turning on genes that caused the cells to proliferate, but also the effect was significant. The parabens in the HER2-activated cells were able to stimulate breast cancer cell growth at concentrations 100 times lower than in cells that were deprived of heregulin.

The study demonstrates that parabens may be more potent at lower doses than previous studies have suggested, which may spur scientists and regulators to rethink the potential impacts of parabens on the development of breast cancer, particularly on HER2 and estrogen receptor positive breast cells. The findings also raise questions about current safety testing methods that may not predict the true potency of parabens and their effects on human health.

Beware of nail polish because it may be contaminating your body with an endocrine disrupting chemical.  A study co-authored by researchers at Duke University and Environmental Working Group (EWG) detected evidence of a common nail polish chemical called triphenyl phosphate, or TPHP, in the bodies of every woman who volunteered to paint her nails for the study.There is growing evidence suggesting that TPHP may affect hormone regulation, metabolism, reproduction and development. Unfortunately, even if it is not listed on the label, it may still be in the product. It is also used as a fire retardant (and the evidence from studies says to avoid fire retardants). Go to the EWG site for more on nail polish brands.From Environmental Working Group (EWG):

Duke-EWG Study Finds Toxic Nail Polish Chemical In Women’s Bodies

Researchers at Duke University and Environmental Working Group have found evidence of a suspected endocrine-disrupting chemical widely used in popular nail polishes in the bodies of more than two-dozen women who participated in a biomonitoring study. The study, published today in Environment International, found that all women had a metabolite of triphenyl phosphate, or TPHP, in their bodies just 10 to 14 hours after painting their nails. Their levels of diphenyl phosphate or DPHP, which forms when the body metabolizes TPHP, had increased by nearly sevenfold.

According to EWG’s Skin Deep® cosmetics database, more than 1,500 nail products including polishes made by Sally Hansen, OPI and Wet N Wild, contain TPHP. Click here for a list of brands that list TPHP as an ingredient. More nail polishes may contain undisclosed TPHP.  The Duke-EWG study tested 10 polishes for TPHP and found the chemical in eight of them. Two of the eight with TPHP did not list the ingredient on their labels.  ...continue reading "Secret Hazard of Nail Polish"

 More and more studies are finding negative health effects from hormone disrupting chemicals (which we are exposed to every single day, and subsequently which are in all of us), such as parabens, phthalates, Bisphenol-A (BPA), and chemical substitutes for BPA such as Bisphenol-S (BPS) and BPF.  The last post had some recent studies that looked at health effects of hormone disrupting chemicals. The following article points out some of the many difficulties in developing packaging that is safe and doesn't leach endocrine disrupting chemicals or even other chemicals.

We generally focus on hormone disrupting chemicals in plastic bottles or metal cans (which their epoxy liners), but other parts of packaging may (or may not) also leach chemicals. Some leaching may occur with the adhesives used to seal foil pouches, and the polypropylene inner layers also may leach stabilizers. Glass jars are OK, but jar lids may be equipped with BPA-based epoxy liners and/or gaskets that leach plasticizers. Greaseproof wrappers may leach poly- and perfluorinated compounds used to make some packaging greaseproof (may occur if packaging is from India and China - because it is legal to import into USA and use).  Some ceramic kitchenware - the glazes used in artisanal pottery and older mass produced ceramics may leach toxic metals, especially lead. There can even be "offset migration" which occurs when the printed outer surface of food packaging transfers chemicals to the inner food-contact surface.  Whew...

Bottom line: Even BPA alternatives (labeled BPA-free) should be viewed as the same as BPA (as endocrine disruptors) - in other words, currently there are no good BPA substitutes. Read labels and try to minimize plastics in personal care products (e.g., lotion, fragrances) and your food if possible (e.g., choose glass, stainless steel, wax paper, aluminum foil). This is especially important during pregnancy.  Don't microwave food in a plastic dish or container, or covered with plastic wrap. Eat fresh foods and try to avoid soda cans and other packaged, processed foods, especially in plastic containers or metal cans. From Environmental Health Perspectives: A Hard Nut to Crack: Reducing Chemical Migration in Food-Contact Materials

When we buy food, we’re often buying packaging, too. From cherries to Cheez-It® crackers, modern foods are processed, transported, stored, and sold in specialized materials that account, on average, for half the cost of the item, according to Joseph Hotchkiss, a professor in Michigan State University’s School of Packaging. Consumer-level food packaging serves a wide range of functions, such as providing product information, preventing spoilage, and protecting food during the journey from production to retail to pantry, fridge, or freezer. That’s why food producers lavish so much time and money on it.

But what happens when these valuable and painstakingly engineered containers leach chemicals and other compounds into the food and drink they’re designed to protect? Such contamination is nearly ubiquitous; it happens every day, everywhere packaged food is found, with all common types of packaging, including glass, metal, paper, and plastic. Even as awareness of the issue grows, large-scale solutions that are scientifically and financially viable remain out of reach. The challenges in reaching them are many.  ...continue reading "Chemicals Migrate From Containers to Food"

More and more studies are finding negative health effects from hormone disrupting chemicals (which we are exposed to every single day, and subsequently which are in all of us), such as parabens, phthalates, Bisphenol-A (BPA), and chemical substitutes for BPA such as Bisphenol-S (BPS) and BPF. The following are a few recent studies and one article from my files. Also check out the other endocrine disrupting chemical studies I've posted (SEARCH: 'endocrine disruptors', and 'phthalates').

Bottom line: Read labels and try to minimize plastics in personal care products (e.g., lotion) and your food if possible (e.g., choose glass, stainless steel, wax paper, aluminum foil). This is especially important during pregnancy.  Even BPA alternatives (labeled BPA-free) should be viewed as the same as BPA - as endocrine disruptors. In other words, currently there are no good BPA substitutes. Don't microwave food in a plastic dish or container, or covered with plastic wrap. Eat fresh foods rather than packaged, processed foods. From Newsweek:

BPA Is Fine, If You Ignore Most Studies About It

Bisphenol-A (BPA) is either a harmless chemical that’s great for making plastic or one of modern society’s more dangerous problems. Depends whom you ask. BPA is in many types of plastics and the epoxy resins that line most aluminum cans, as well as thermal papers like receipts. It is an endocrine disruptor that mimics estrogen, a hormone especially important in sexual development, and the fact that it’s all over the place worries many people. Newsweek spoke with about 20 scientists, leaders in the field of BPA research, and the majority say it is likely (though not certain) that the chemical plays a role in a litany of health concerns: obesity, diabetes, problems with fertility and reproductive organs, susceptibility to various cancers and cognitive/behavioral deficits like ADHD ...continue reading "More Negative News About Hormone Disrupting Chemicals"

A report released this week by the Endocrine Society states that the list of health problems that scientists can confidently link to exposure to hormone-disrupting chemicals has grown to include: diabetes, cardiovascular disease, obesity, reproductive and developmental problems, thyroid impairment, certain reproductive cancers, and neurodevelopmental problems such as decreased IQ. This statement (report) is based on the summaries of 1300 studies on endocrine disrupting chemicals (EDCs), and it also adds support to the idea that even minute doses of these chemicals can interfere with the activity of natural hormones, which play a major role in regulating physiology and behavior. The statement also stated that most industrial chemicals released into the environment—numbering in the tens of thousands—have never been tested for endocrine-disrupting potential. EDCs include such common chemicals as bisphenol A (BPA), phthalates, parabens, some pesticides (e.g., atrazine), flame retardants, some persistent organic pollutants, and dioxins.

Where are endocrine disruptors found? People are exposed to chemicals with estrogenic effects in their everyday life, because endocrine disrupting chemicals are found in low doses in thousands of products. Many plastic products, including those advertised as "BPA free", have been found to leach endocrine-disrupting chemicals (the substitute chemicals are no better than BPA, and may be worse). Examples: plastic food containers which then leach into foods, linings of metal beverage, formula, and food cans, soft plastic toys, dental sealants, consumer goods, receipts, personal care products that contain parabens or phthalates (e.g., found in lotions,sunscreens, fragrances), household products (such as cleaning products, vinyl shower curtains) , cars (that new car smell in car interiors), etc. Americans love plastics, but there is a serious human health cost.

NOTE: To minimize EDC exposure - try to avoid plastic food and beverage containers. Instead try to use glass, stainless steel, or ceramics. Eat as many unprocessed and fresh foods as possible. Use cloth shower curtains. Read labels and avoid BPA, phthalates, parabens. Avoid fragrances. Don't use or buy non-stick pans, stain and water-resistant coatings on clothing, furniture and carpets. When buying new furniture, check that it doesn't have added fire retardants.

Of course any public discussion of the harms from endocrine disrupting chemicals, as well as the newly released Endocrine Society report, is drawing sharp criticisms from the chemical industry (especially the American Chemistry Council, the largest trade group for the chemicals industry). Of course. We all know that the lobbying efforts by the chemical industry to suppress and deny the evidence of harm to humans from EDCs has been and will continue to be massive. Sadly, but at this point EDCs are found in almost everyone on earth. More about the report, from Science Daily:

Chemical exposure linked to rising diabetes, obesity risk

Emerging evidence ties endocrine-disrupting chemical (EDC) exposure to two of the biggest public health threats facing society -- diabetes and obesity. EDCs contribute to health problems by mimicking, blocking or otherwise interfering with the body's natural hormones. By hijacking the body's chemical messengers, EDCs can alter the way cells develop and grow. Known EDCs include bisphenol A (BPA) found in food can linings and cash register receipts, phthalates found in plastics and cosmetics, flame retardants and pesticides. The chemicals are so common that nearly every person on Earth has been exposed to one or more.  ...continue reading "New Report About Harms of Endocrine Disruptors"