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Category: healthy aging

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 Well, it looks like the researchers devised a nutritional supplement, which they then tested and found beneficial effects on the thinking processes of older adults - so some bias there, but still interesting. What was in the supplement they called NT-020? Extracts of blueberries, green tea, vitamin D3, and amino acids such as carnosine. Science Daily:

Nutritional supplement improves cognitive performance in older adults, study finds

Now a University of South Florida (USF) study reports that a formula of nutrients high in antioxidants and other natural components helped boost the speed at which the brains of older adults processed information.

The USF-developed nutritional supplement, containing extracts from blueberries and green tea combined with vitamin D3 and amino acids, including carnosine, was tested by the USF researchers in a clinical trial enrolling 105 healthy adults, ages 65 to 85. The two-month study evaluated the effects of the formula, called NT-020, on the cognitive performance of these older adults, who had no diagnosed memory disorders.

Those randomized to the group of 52 volunteers receiving NT-020 demonstrated improvements in cognitive processing speed, while the 53 volunteers randomized to receive a placebo did not. Reduced cognitive processing speed, which can slow thinking and learning, has been associated with advancing age, the researchers said. Blueberries, a major ingredient in the NT-020 formula, are rich in polyphenols, a type of antioxidant containing a polyphenolic, or natural phenol substructure.

In several preclinical trials, researchers gave aging laboratory rats NT-020 to see if it boosted memory and other cognitive performance by promoting the health of neurons in the aging brain. Those studies demonstrated that NT-020 promoted the growth of stem cells in the brain, produced an overall rejuvenating effect, benefited animals with simulated stroke, and led to better cognitive performance.

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From the Medical Daily:

High Blood Pressure In Teens, Young Adults A Sign Of Hardened Arteries Down The Road

Your blood pressure during your teens and early twenties, though often naturally low due to youth, may have something to do with your cardiovascular health in later years, according to new research from Northwestern University Feinberg School of Medicine. In the new study, which was published in JAMA, researchers found that having higher blood pressure during your teens and twenties was actually linked to hardened arteries at age 40.

The study, led by epidemiologist Norrina Allen, points out the significance of maintaining cardiovascular health at a young age.

The study reviewed 4,600 men and women throughout several different states and followed them for 25 years. They found that 19 percent of them had blood pressure that was much higher than their peers, and that another 5 percent started with high blood pressure that gradually rose. Though these blood pressure readings fell within “normal” range for their age, it was higher than average and thus they were more likely to develop hypertension by age 40. Hypertension is also known as high blood pressure or arterial hypertension.

“While you wouldn’t prescribe medications for this group, you might have conversations with those individuals about ways they can improve their diet or increase physical activity,” Allen told NPR. She notes that “many of these cardiovascular risk factors are cumulative,” meaning they often occur over a long period of time and are a combination of things, from smoking to living a sedentary lifestyle.

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The study results suggest that the effect of higher levels of omega-3 fatty acids on brain volume is the equivalent of delaying the normal loss of brain cells that comes with aging by one to two years. The researchers suggest that these higher levels can be achieved through diet or the use of supplements (about 1000 mg of EPA + DHA daily, or by eating a portion of fish such as salmon or sardines every day).  From the January 22, 2014 Science Daily:

Can fish oil help preserve brain cells?

People with higher levels of the omega-3 fatty acids found in fish oil may also have larger brain volumes in old age equivalent to preserving one to two years of brain health, according to a study published in the January 22, 2014, online issue of Neurology, the medical journal of the American Academy of Neurology. Shrinking brain volume is a sign of Alzheimer’s disease as well as normal aging.

For the study, the levels of omega-3 fatty acids EPA+DHA in red blood cells were tested in 1,111 women who were part of the Women’s Health Initiative Memory Study. Eight years later, when the women were an average age of 78, MRI scans were taken to measure their brain volume.

Those with higher levels of omega-3s had larger total brain volumes eight years later. Those with twice as high levels of fatty acids (7.5 vs. 3.4 percent) had a 0.7 percent larger brain volume.

Those with higher levels of omega-3s also had a 2.7 percent larger volume in the hippocampus area of the brain, which plays an important role in memory. In Alzheimer’s disease, the hippocampus begins to atrophy even before symptoms appear.

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Another positive piece of news for those getting on in years. From Jan. 20, 2014 Science News:

Forget About Forgetting: Elderly Know More, Use It Better

What happens to our cognitive abilities as we age? If your think our brains go into a steady decline, research reported this week in the Journal Topics in Cognitive Science may make you think again. The work, headed by Dr. Michael Ramscar of Tübingen University, takes a critical look at the measures usually thought to show that our cognitive abilities decline across adulthood. Instead of finding evidence of decline, the team discovered that most standard cognitive measures, which date back to the early twentieth century, are flawed. "The human brain works slower in old age," says Ramscar, "but only because we have stored more information over time."

Ramscar and his colleagues' work provides more than an explanation of why, in the light of all the extra information they have to process, we might expect older brains to seem slower and more forgetful than younger brains. Their work also shows how changes in test performance that have been taken as evidence for declining cognitive abilities in fact demonstrates older adults' greater mastery of the knowledge they have acquired.

The Tübingen research conclude that we need different tests for the cognitive abilities of older people -- taking into account the nature and amount of information our brains process. "The brains of older people do not get weak," says Michael Ramscar. "On the contrary, they simply know more."