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Published on Leave a comment on A Promising Antibiotic For Gum Disease

The bacteria Fusobacterium nucleatum is prevalent in periodontal disease (gum disease), but also in some chronic diseases and cancers, such as colorectal cancer. The bacteria F. nucleatum is normally found in the mouth (oral) microbiome, and its numbers increase as periodontal disease inflammation increases.

It is thought that sometimes the bacteria leaves the mouth and travels to other parts of the body, where it can promote cancer and other diseases.

A recent study found that the antibiotic FP 100 (Hygromycin A) totally eliminates the F. nucleatum bacteria in the mouth, and without causing harm to the mouth microbiome or gut microbiome. This is because it is a narrow spectrum antibiotic - only targets the harmful bacteria, and not all (both good and harmful) bacteria. While the study was only done in mice, this is promising and welcome news.

Eliminating the harmful bacteria in the mouth would potentially prevent some chronic diseases and cancers. Now we need further studies to see if this finding holds up in humans.

From Medical Xpress: First narrow-spectrum antibiotic successfully eliminates  Fusobacterium nucleatum, a gum disease pathogen

In a study published in the Journal of Oral Microbiology, ADA Forsyth scientists found that FP 100 (Hygromycin A), a first-in-class, small molecule, narrow-spectrum antibiotic, successfully eradicates Fusobacterium nucleatum without harming the oral or gut microbiomes. ...continue reading "A Promising Antibiotic For Gum Disease"

Published on Leave a comment on Brain Disease Cluster In Canada

The province of New Brunswick in Canada is home to a mysterious cluster of brain diseases in some of its residents - even in young persons in their 20s and 30s. The numbers of persons stricken (currently 430) with neurodegenerative brain diseases and dying is growing, and at this time no one knows exactly why this is happening.

One possibility is pesticide exposure, especially the pesticide (herbicide) glyphosate. Glyphosate is heavily used in the province in the forest industry, which is also a main industry. The herbicide is heavily used in clear cuts and tree plantations.

Lab tests found incredibly high levels of the pesticide glyphosate in the persons with the neurological symptoms. But after these results were revealed, the provincial government basically shut all research down. A doctor who was instrumental in bringing attention to this mysterious brain disease cluster was muzzled. Uh oh... a political and industry cover up?

The NY Times did an in-depth investigation, and the article written by Greg Donohue makes for fascinating reading.  They All Got Mysterious Brain Diseases. They're Fighting to Learn Why.

The article pointed out that recent studies have shown that glyphosate crosses the blood-brain barrier, and that chronic exposure can lead to neurological inflammation that can trigger Alzheimer’s disease. There is a link between glyphosate and an increased risk for Parkinson's disease and other health problems, including cancer.

A further discussion of that investigation and the role of pesticides (glyphosate) in brain diseases. Good list of references for more information. Excerpts from Beyond Pesticides: One Of World's Largest Dementia Clusters In Young People May Be Tied To High Blood Levels Of Glyphosate

A piercing investigative article in the August 14 New York Times by journalist Greg Donahue reveals the abandonment of a group of brain disease patients in an area of Canada with forestry management for paper products, agriculture, and large amounts of pesticide use, including glyphosate. ...continue reading "Brain Disease Cluster In Canada"

Published on Leave a comment on Slow Death For A Pollinator
Dying pollinator

There was a rare sighting of an insect pollinator in my yard recently. Unfortunately, it was dying. I suspect that pesticides were the cause of the slow death.

The ordinary person has no clue how damaging pesticide applications on their lawns and plants can be to insects living nearby. To pollinators (e.g., bees and wasps). To entire insect and bird ecosystems.

On the day I saw the dying insect pollinator, an immediate neighbor had not one, but two pesticide applications by two different services in one day! One service was for their lawn, and the second one was for mosquitos (using pyrethroid and cypermethrin insecticides) with a device that looks like a leaf blower. This device is held at waist-height (a high volume application).

Soon after that I found the dying, but still twitching, pollinator on the hood of my car (close to the property line). As I've discussed before, since the neighbor started mosquito pesticide applications 2 years ago, I rarely see a bee, wasp, or butterfly in my organic yard. At most, maybe one bee every 2 months? Before that, there were many daily.

The mosquito applications are done using cypermethrin and pyrethroid insecticides (which are synthetic pesticides, e.g., made by Fendona). Pyrethroids are known to be highly toxic to pollinators such as bees and wasps, and there is growing evidence of harms to humans (here, here).

Of course, when pesticides are applied, they drift and travel to non-target neighboring areas. It's sad. But totally legal.

Published on Leave a comment on Older Women Are More Vulnerable to High Summer Heat
Thermometer Credit: Wikipedia

It turns out that older women are more susceptible to high heat and humidity then older men. Older women feel it more! (In science speak: women are physiologically more vulnerable to high heat and humidity, that is, heat stress vulnerability)

Researchers found that middle-aged and older women were affected by heat at lower temperature and humidity combinations than middle-aged and older men. Women between the ages of 40 and 64 are as vulnerable as men 65 years and older. The researchers said that biological sex (male or female) and age appear to be the primary drivers of heat vulnerability among healthy people.

There were no differences in heat vulnerability between male and female younger adults. Also, fitness of individuals made very little difference in heat vulnerability.

Researchers tested the heat thresholds (combined heat and humidity) of 72 participants between the ages of 42 and 92 years in a specialized environmental chamber. Participants swallowed a special device which measured their core temperature throughout the experiment. NOTE: When core temperatures rise, people are more vulnerable to heat exhaustion, heat stroke, and even death.

From Science Daily: Older women more vulnerable to heat than their male peers, researchers find

As global climate change causes extreme heat waves to become more common around the world, epidemiological studies have shown that heat kills more women than men. Now, a new study by researchers at Penn State has found that older women are physiologically more vulnerable to high heat and humidity than older men, and that women between the ages of 40 and 64 are as vulnerable as men 65 years of age or older. This is the first study to determine this disparity exists due to physiological differences rather than because women live longer than men -- leaving a larger population of older women than older men. ...continue reading "Older Women Are More Vulnerable to High Summer Heat"

Published on Leave a comment on Summer 2024 Was the Hottest On Record

Summer 2024 was the hottest summer on record, and this is following last summer (June through August) - which was the hottest summer globally up to that point. As you can see, the bar keeps rising.

Looking back years from now, we may view the summer of 2024 as "cool" compared to what's ahead....  Climate change, of course. The world is in uncharted territory now.

From Yale E360 (Yale School of the Environment): This Summer Was the Hottest on Record

The summer of 2024 set new records, European scientists have found. The world has never seen temperatures reach so high between June and August. ...continue reading "Summer 2024 Was the Hottest On Record"

Published on Leave a comment on Diet and Risk of Developing Dementia

One message keeps being supported by research: Eat a diet rich in fruits, vegetables, seeds, nuts, whole grains, legumes, and olive oil. A reason is because this diet is anti-inflammatory. And it turns out that inflammation is at the root of many diseases, including heart disease. And dementia.

A recent study that followed more than 84,342 older adults (60 years or older at the start of the study) found that those who ate an anti-inflammatory diet had a 21% lower chance of developing dementia. They also had larger gray matter volume in the brain, and smaller white matter lesions or spots in the brain (white matter hyperintensity volume). All of the adults had cardiometabolic diseases (e.g., heart disease, diabetes, stroke) at the start of the study.

Other studies have already confirmed that eating an anti-inflammatory diet (e.g., Mediterranean diet) is linked to lower risk of diabetes, heart disease, lower dementia risk, better cognitive function, and better brain aging (as measured by MRI scans).

From Medical Xpress: Anti-inflammatory diet could lower your odds for dementia

Eating a healthy diet that dampens inflammation in the body could lower your odds for dementia, especially if you already have heart risk factors, a new Swedish study shows. ...continue reading "Diet and Risk of Developing Dementia"

Published on Leave a comment on Low Levels of Magnesium Can Increase the Risk of Some Diseases

A diet rich in a variety of healthy foods (fruits, vegetables, whole grains, seeds, nuts, legumes) is important because of all the micronutrients it provides. For example, magnesium. A recent study found that low magnesium levels are linked to an increased risk of DNA damage and chronic diseases.

The reason is that low levels of magnesium in the body are associated with high amounts of homocysteine. The researchers felt that the study results indicate that "sufficiently high magnesium levels in the blood are essential to protect our genes from toxicity caused by homocysteine". Homocysteine levels increase when folate and B12 levels are deficient.

Some magnesium facts: It's the 4th most abundant mineral found in the body. It is involved with various functions in the body, including strengthening and development of bones, nerve function, regulating blood sugar and blood pressure, and DNA repair.

Magnesium rich foods are whole grains, dark green leafy vegetables (especially spinach and kale), nuts (especially, almonds, cashews, peanuts), beans, seeds (especially pumpkin and chia seeds), potatoes, rice, oatmeal, bananas, and dark chocolate.

Medical Xpress: Low magnesium levels are linked increased disease risk, study shows

A new Australian study has identified why a diet rich in magnesium is so important for our health, reducing the risk of DNA damage and chronic degenerative disorders. ...continue reading "Low Levels of Magnesium Can Increase the Risk of Some Diseases"

Published on Leave a comment on More Reasons To Avoid Artificial Sweeteners

The artificial sweetener erythritol is added to many foods. However, this sugar substitute (which is often blended with stevia) may cause health problems . A recent small study found that consuming typical "sugar-less" foods, such as erythritol sweetened drinks or erythritol sweetened muffins, more than doubled the risk of blood clotting in healthy volunteers.

After consuming the drinks, their bodies made platelets (a type of blood cell) more active, which can raise the risk of blood clots. This did not happen after consuming regular sugar (glucose).

The researchers suggest instead of artificial sweeteners, to use sugar, honey, or fruit, but in moderation.

From Medical Xpress: New study adds to increasing evidence that sugar substitute erythritol raises cardiovascular risk

New Cleveland Clinic research shows that consuming foods with erythritol, a popular artificial sweetener, increases the risk of cardiovascular events such as heart attack and stroke. The findings, from a new intervention study in healthy volunteers, show erythritol made platelets (a type of blood cell) more active, which can raise the risk of blood clots. Sugar (glucose) did not have this effect. ...continue reading "More Reasons To Avoid Artificial Sweeteners"

Published on Leave a comment on Dogs Can Detect The Smell of Chronic Wasting Disease

Dogs and their ability to detect diseases through their smelling abilities could be important in efforts to control the spread of the prion disease called chronic wasting disease (CWD). Different diseases, including CWD, have characteristic odors or scents.

CWD is an always fatal neurologic prion disease (similar to mad cow disease)  that is slowly spreading through deer,moose, and elk populations throughout the US and Canada. A recent study found that dogs trained to detect the odor of CWD were able to detect CWD in deer feces with over 80% accuracy.

Currently there is no way to detect the disease in animals before symptoms set in. The fear is that while the disease is now limited to deer, moose, and elk, it could make a cross-species jump to humans. (More information)

From CIDRAP (Center for Infectious Disease Research & Policy): Study: Dogs can detect chronic wasting disease in white-tail deer

Chronic wasting disease, a fatal prion disease found in cervids, can be detected by dogs trained to identify the scent, according to a new study published today in PLoS One. The dogs were able to identify infected deer through feces samples. ...continue reading "Dogs Can Detect The Smell of Chronic Wasting Disease"

Published on Leave a comment on Cranberry Juice Helps Prevent Urinary Tract Infections

A recent review of studies looked at whether cranberry juice helps with urinary tract infections (UTIs) and the results were encouraging. Yes, cranberry juice or cranberry tablets help in preventing UTIs.

Twenty well-done studies were reviewed. Drinking cranberry juice or taking a cranberry tablet resulted in a 27 to 54% lower rate of UTIs (the numbers varied between studies), and a 49% to 59% lower rate of antibiotic use. Cranberry compounds reduced the prevalence of UTI symptoms. These are great results!

The majority of women suffer from a UTI at some point in their life, and some women suffer frequently - many times a year. Antibiotics have long been the treatment of choice, but antibiotic resistance is increasing, so finding something that prevents UTIs is important.

By the way, cranberries and cranberry juice has been promoted for decades as both UTI prevention and treatment. [Other treatment possibilities for treatment and prevention are: D-mannose, drinking more water, the probiotic L. crispatus, and an oral vaccine.]

From Medscape: It's in the Juice: Cranberries for UTI Prevention

A systematic review and network meta-analysis found cranberry juice can help prevent urinary tract infections (UTIs). ...continue reading "Cranberry Juice Helps Prevent Urinary Tract Infections"