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Small intestine Credit: Wikipedia

A new study highlights the importance of eating a variety of foods for good health. Researchers found that humans have 5 distinct regions in the small intestine, and each region absorbs different nutrients and has different cellular functions. And each zone responds to changes in the diet.

The researchers said that this helps understand how the small intestine successfully regenerates over the life span, as well as clues as to the development of some intestinal diseases. They also discovered that there are 3 regions in the small intestine that are each home to distinct intestinal stem cell types.

Bottom line: Be good to your intestines (and in doing so, promote good health) by eating a variety of real foods. That means a diet rich in whole grains, fruits, vegetables, seeds, nuts, legumes (beans). Try to eat as many organic foods as possible (non-organic foods contain pesticide residues that can disrupt gut microbiome). Try to avoid ultra-processed foods as much as possible.

From Medical Xpress: Scientists gain new insights into how small intestine works

However, the organ may finally be ready for an update: U.S. researchers say the small intestine is actually comprised of five distinct segments, each being responsible for the absorption of various nutrients. ...continue reading "The Five Regions of the Small Intestine"

A recent large Swedish study found that men who increased their cardiorespiratory fitness had a  significantly lower prostate cancer risk (when compared to men whose cardiorespiratory fitness stayed the same or declined) .

Men who increased their fitness by more than 3% over the course of a year had a 35% lower risk of prostate cancer during the 7 year follow-up. Cardiorespiratory fitness was measured two times (baseline and a year later) by peddling on a stationary cycle and measuring absolute and relative VO2 max - the amount (volume) of oxygen the body uses while exercising as hard as possible.

By the way, other studies also find that cardiorespiratory fitness is associated with the risk of some cancers, as well as dying from certain cancer types. This study did not find an increase in cancer deaths, but it also only followed the men 7 years.

Bottom line: Increase your activity levels! Walking, hiking, bicycling gardening, sports, exercises - it all counts. You can do it!

From Medical Xpress: Increase in annual cardiorespiratory fitness by more than 3% linked to 35% lower prostate cancer risk

An increase in annual cardiorespiratory fitness by 3% or more is linked to a 35% lower risk of developing, although not dying from, prostate cancer, suggests research published online in the British Journal of Sports Medicine. ...continue reading "Improve Fitness To Lower Risk of Prostate Cancer"

Waterproof jacket From Wikipedia

Finally.... the EPA is proposing that 9 PFAS chemicals called "forever chemicals" be labelled as "hazardous to human health" or "hazardous constituents". This means that the chemicals are toxic or cause cancer, genetic mutations, or malformations of an embryo (developing baby). There actually are thousands of PFAS chemicals, but the FDA is only focusing on 9 of them.

PFAS (per- and polyfluoroalkyl substances) are called forever chemicals because they break down very slowly and they tend to accumulate, both in the environment and in humans. They are endocrine disruptors (disrupt hormones).

In humans and animals these harmful chemicals cause numerous health effects, including cancer, reproductive harm (e.g., poorer semen quality), birth defects, lowered sex and growth hormones in children, thyroid disease, immune effects, and liver and kidney damage.

Nonstick pan Credit: Wikipedia

Almost all of us have PFAS in our bodies (at varying levels). It's very hard to avoid them totally, but you should try to minimize exposure. Unfortunately, these chemicals are in all sorts of consumer products that we are exposed to frequently or daily. For example: non-stick cookware, firefighting foam, synthetic turf, cosmetics, and materials that protect against grease, oil, and water (e.g., stain-resistant carpeting and fabrics, food packaging, and water-repellent clothing).

What can you do? If possible, avoid products that are water and stain proof or leak-proof, especially if children will be using the product. (For ex., can look for physical barriers instead of a chemical coating). Don't use nonstick cookware. PFAS don't have to be mentioned on labels, so it's buyer beware.

Excerpts from NPR: The EPA is proposing that 'forever chemicals' be considered hazardous substances

The Environmental Protection Agency is proposing that nine PFAS, also known as "forever chemicals," be categorized as hazardous to human health.

The EPA signed a proposal Wednesday that would deem the chemicals "hazardous constituents" under the Resource Conservation and Recovery Act. ...continue reading "EPA Finally Proposing Some Forever Chemicals As Hazardous"

There is much concern with the amount of highly or ultra-processed foods the typical American eats - over 50% of the calories eaten daily! Ultra-processed foods are linked to all sorts of health issues (e.g., diabetes, heart disease). One reason is because these foods are not good for the gut microbiome - they feed microbes linked to poor health and not the microbes linked to good health.

So how does one know if a food is ultra-processed? An easy way is to look at the ingredients list on the package or container and look for one or more ingredients not normally found in our kitchens at home. Instead, these ingredients will have chemical sounding names.

What ingredients indicate a food is ultra-processed? Some examples indicating a food is ultra-processed: soy lecithin, carrageenan, high-fructose corn syrup,  hydrogenated oils, interesterified oils, hydrolysed proteins, invert sugar, dextrose, lactose, gluten, whey protein, nitrates, flavors, colors, titanium dioxide, caramel color, and emulsifiers. The list goes on and on. Even the innocent sounding "natural flavors" is a laboratory concoction.

These ingredients have typically been added to extend shelf-life or manipulate the taste, flavor, or appearance. Ultra-processed foods are "formulations of ingredients" that result from a series of industrial processes (thus "ultra-processed"). Researchers of the following article say that "ultra-processed foods are not real food" due to all the modifications and alterations.

Note that ultra-processed foods can be on the grocery shelf right next to similar foods with all natural ingredients. Examples are breads, cereals, and maple syrup (is it real maple syrup or an ultra-processed concoction?). This is why you should read ingredient lists.

Also, these foods are generally ultra-processed: soda, candy, margarines, cake mixes, hot dogs and processed meats (e.g., cold cuts), instant soups, mass-produced breads and cookies, frozen meals, fast food meals, energy bars and drinks, and protein bars.

By the way, most foods that we buy or cook at home are processed to some extent, for example pasteurization of milk, freezing or boiling foods, fermentation, seasoning foods, cooking food, or even baking bread. Using real foods to prepare (process) food is OK for our health. It's totally fine.

Foods can be unprocessed (e.g., raw fruits and vegetables), minimally processed, processed, and finally ultra-processed. The ingredients will tell you if it's just processed food (contains only normal foods or culinary ingredients - e.g., flour, sugar, salt, eggs) or whether it's ultra-processed (contains one or more chemical sounding ingredients).

These foods are NOT ultra-processed: pasteurized milk, raw fruits and vegetables, starchy roots and tubers (e.g., potatoes, yams), chilled meat and fish, plant oils (e.g., olive oil), sugar, oats, and salt.

A big problem is that ultra-processed foods are replacing unprocessed or minimally processed foods in our diet. This is also why we are getting less and less fiber in our diet, which is linked to health problems. Simple way to think about it: fiber from foods feeds beneficial gut microbes.

Excerpts from an April 2019 article in Public Health Nutrition: Ultra-processed foods: what they are and how to identify them

Ultra-processed foods are defined within the NOVA classification system, which groups foods according to the extent and purpose of industrial processing.

...continue reading "How to Identify An Ultra-Processed Food"

There is another very good book to read about environmental causes of cancer. It's called A New War On Cancer: The Unlikely Heroes Revolutionizing Prevention by Kristina Marusic. Published by Island Press in 2023.

What makes this book so interesting is that it profiles everyday individuals who are actively working towards preventing cancers caused by environmental causes. They are  doing this by devoting their lives towards preventing cancers caused by pollution and chemicals implicated in causing cancer (e.g., pesticides, endocrine disruptors).

I found myself marking up the book as I read - so many good quotable statements. In the end it was a book that offers hope, and things we can all do.

The forward is written by Dr. Philip Landrigen - a famous researcher looking at toxic chemicals (e.g., pesticides, lead, chemicals in Gulf War Veterans' Illnesses) and how they impact human health. He is one of the world's leading advocates for children's health.

Book: A New War on Cancer: The Unlikely Heroes Revolutionizing Prevention By Kristina Marusic, with a Forward by Philip J. Landrigan , Island Press , 2023.

Kidney stones Credit: Wikipedia

What causes a person to develop kidney stones has long been debated. A recent study found that in persons who develop kidney stones, there are alterations in the gut, salivary, and urinary microbiomes. In other words, the community of fungi, viruses, and bacteria at each of these sites are out of whack or imbalanced.

In the study, not only were the 3 microbiomes imbalanced in the persons with kidney stones (when compared to healthy people without kidney stones), but they also had less diversity (fewer species) in their microbiomes. For example, persons with kidney stones had significantly fewer gut health associated bacteria F. prausnitzii, and significantly more inflammation associated E. lenta.

Those with kidney stones also had a history of having taken more antibiotics (antimicrobials).

The researchers conclusion: To avoid kidney stones a healthy diet is essential (for a healthy gut microbiome). One should also avoid taking antibiotics unless necessary. [BTW, the bacteria F. prausnitzii has long been viewed as a keystone microbe in a healthy gut microbiome. It can be increased by increasing fiber in the diet - e.g., fruits, vegetables, seeds, nuts, whole grains, legumes.]

From Medical Xpress: New study sheds light on the connection between the microbiome and kidney stones

A new study from Lawson Health Research Institute and Western University published in the journal Microbiome has found changes in the microbiome in multiple locations in the body are linked to the formation of kidney stones. ...continue reading "Kidney Stones and the Gut Microbiome"

This is so true.... Researchers found that American adults eat about one meal's worth of snacks over the course of each day. That's about 400 to 500 calories, or almost one quarter of daily calories. Also, the snacks are typically poor nutritionally -  with lots of sugar and low in fiber.

Bottom line: If you snack, then try to have nutritionally good snacks, such as fruit or nuts (and not just chips, cookies, and candy). This way the snacks will be a source of nutrients and fiber (all good!).

From Science Daily: US adults eat a meal's worth of calories of snacks in a day

Snacks constitute almost a quarter of a day's calories in U.S. adults and account for about one-third of daily added sugar, a new study suggests. ...continue reading "Study Finds Adults Eat A Meal’s Worth of Snacks Each Day"

There appears to be a big downside to an all plant diet, which is the possibility of missing essential nutrients that are found in dairy and meat (e.g., vitamin B12, vitamin D3, iron, zinc, choline).

This is especially worrisome if a woman is pregnant (developing baby) and also in children (developing body and brain). Nutrient status is important both before conception and during pregnancy for both a healthy pregnancy and baby.

A recent study looking at vitamin status in women both before conception and during pregnancy in 3 high-income countries found that over 90% of the women had marginal or low concentrations of 1 or more important nutrients: folate (folic acid), riboflavin, vitamin B12, or vitamin D before conception, and many developed vitamin B6 deficiency in late pregnancy.

All women took vitamin supplements containing folic acid, beta-carotene, iron, calcium, and iodine during pregnancy. However, one group took supplements that additionally had riboflavin, vitamins B6, B12, and D, zinc. The researchers found that the group with additional vitamins  had higher (better) levels of the nutrients throughout pregnancy.

The study results show that multivitamins should already be taken during the preconception period. Multivitamins should be continued after pregnancy while breastfeeding a baby to maintain adequate levels of essential nutrients.

From Science Daily: Pregnant women are missing vital nutrients needed for them and their babies

Pregnant women are not getting the essential nutrients they and their babies need from modern diets say scientists, who have warned that the situation will likely worsen as more people turn to plant-based foods. ...continue reading "Many Women Have Low Levels of Important Nutrients Before Pregnancy"

Interesting, yet disturbing, research found microplastics in human placentas and also that the microplastic contamination of placentas has been rising steadily since 2006. During this time global plastic production has also increased.

Microplastics are the teeny, tiny plastic particles (less than 5mm or .20 inches in length) that are a result of plastics breaking up over time. The big question now is: Are microplastics also getting into the fetus? 

University of Hawaii researchers examined 10 healthy human placentas in each of these years: 2006, 2013, and 2021. Microplastics were found in six of the 10 (60%) in 2006, 9 out of the 10 (90%) in 2013, and in all placentas (100%) in 2021. Only a sample (50 grams) was taken from each placenta, but it was clear that the number of microplastics found also increased over time:  22 particles from 2006, 38 particles in 2013, and 82 particles in 2021.

Microplastics Credit: Wikipedia

Another concern is that microplastic particles leach chemicals, and also that some of the particles found in the placentas had endocrine disrupting properties. It is unknown at this time what the effects are from microplastic accumulation in our bodies. Perhaps they have no effect, but absolutely no one thinks they are beneficial. So far other research has found microplastics in the human gut, lungs, bloodstream, and reproductive organs (male testes, female breasts).

Microplastics are of concern to all of us because we are ingesting them in our foods and beverages (especially bottled water), absorbing them through our skin, and breathing them in. Think of all the plastic products we use (e.g., toothpaste, bottled water, computers, cell phones, plastic bags) and wear (synthetic fabrics) daily.

From Science Daily: Rise of microplastics discovered in placentas of Hawaii mothers

A placenta (commonly known as the "afterbirth" or "ʻiewe" in Hawaiian) is a temporary organ which connects the mother to the fetus via the umbilical cord. Its purpose is to deliver nutrients and oxygen to the fetus while serving as a barrier to prevent infections or viruses from entering the developing fetus. ...continue reading "Microplastics Found In Placentas"

For years research has linked some pesticides and toxic chemicals with the development of Parkinson's disease. Recent research from the military base Camp Lejeune strongly suggests that one possible cause of PD is the toxic chemical trichloroethylene (TCE). The drinking water at Camp Lejeune was contaminated with high levels of TCE and perchloroethylene (PCE) for 35 years at 280 times safety standards.

In the past century, TCE (and the similar chemical PCE) has had numerous industrial, consumer, military, and medical applications. For example, it is used in dry cleaning clothes, removing paint, as a degreaser, carpet cleaner, and engine cleaner. It even was used to produce  decaffeinated coffee in the past! It's still used today - much less in the US, but increasing in China.

The problem is that TCE is environmentally persistent, and contaminates soil, air, and water. Vapors from underground water and soil contamination seep out into homes, schools, and workplaces. It is known to be carcinogenic (cancer causing) and associated with numerous cancers and other health harms, including birth defects.

The neurologist Ray Dorsey (at Univ. of Rochester), who was part of a team looking at TCE and Parkinson's disease (see post), was recently interviewed about the research linking TCE and PD. One finding: there has been a major increase in Parkinson's disease in the past decades, making it the "world's fastest-growing brain disease".

What you can do: Dr. Ray Dorsey (and fellow researchers) feel that PD is preventable. (their book). He recommends that everyone, but especially all persons with Parkinson's disease, try to avoid pesticides as much as possible. For example, use a carbon filter for drinking water, eat organic foods, don't put pesticides on the lawn, etc.

Excerpts from Dr. Subramanian (Professor at UCLA) interview with Dr. Ray Dorsey, from the medical site Medscape: Is Most Parkinson's Disease Man-Made and Therefore Preventable?

Subramanian: I wanted to first highlight some of the work that has come out and gotten a large amount of media attention around Camp Lejeune and specifically trichloroethylene (TCE) as a cause of Parkinson's, and one of the environmental toxins that we talk about as something that is in pretty much everywhere. This paper came out, and you wrote a commentary in JAMA Neurology as well. Perhaps we can summarize the paper and its findings. ...continue reading "The Case For Some Toxic Chemicals Causing Parkinson’s Disease"