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Category: human microbiome

Published on Leave a comment on Are You Ready to Eat Insects?
Cricket Credit: Wikipedia

Ready to eat some insects for your gut health? Hah! A recent research paper made the case that eating insects will improve the gut microbiome and health.

The researchers point out that eating insects already happens throughout the world. Edible insects are good sources of protein, micronutrients, and contain dietary fiber and omega-3 fatty acids. Also, insects can be farmed using fewer resources than conventional livestock (e.g., beef, pigs)

The most commonly consumed insects: beetles, caterpillars, wasps, bees, ants, grasshoppers, true bugs; and termites.

From Science Daily: Chitin from consuming insects can help both gut microbiota and global health

Chitin (kai'tin) and healthy fats from insects appear to contribute to healthy gut microbiota and are strong sources of protein and nutrients, according to a paper co-authored by a Colorado State University researcher and published in Nature Food. ...continue reading "Are You Ready to Eat Insects?"

Published on Leave a comment on Psoriasis Has A Microbiome
Healthy skin Credit: Wikipedia

Well, the results of new research about skin with psoriasis compared to healthy skin isn't surprising. The research found that skin with psoriasis has a distinct microbiome (community of bacteria, viruses, fungi) - one that is different from that of healthy persons.

A main finding was that the types of bacteria were lower (less diversity) on the psoriatic skin. Greater diversity of bacteria is considered good - a sign of health. Levels of Staphylococcus were higher in the psoriatic skin, but healthy skin had higher levels of Cutibacterium and Kocuria.

Oher research also supports the view that microbes are somehow involved with the development of psoriasis. The hope is that someday treatment could be just taking a probiotic pill or applying certain microbes to the skin, perhaps in a lotion. Wouldn't that be great?

Excerpts from Medscape: Psoriasis and Psoriatic Arthritis Show Distinctive Skin Microbiomes

The bacterial diversity in lesional and nonlesional skin of patients with psoriasis (PsO) with or without psoriatic arthritis (PsA) was significantly lower than that of healthy control skin, based on data from 74 individuals. ...continue reading "Psoriasis Has A Microbiome"

Published on Leave a comment on Healthy Babies Have Thousands of Viruses In The Gut
Toddler Credit: Wikipedia

It turns out that the baby gut microbiome is loaded with all sorts of viruses, and most of the species were unknown till now. All the viruses living in the gut is the virome. Analyzing baby poop is a way to find out what viruses live in the gut (intestines) of babies.

A team of scientists did an in-depth analysis of the poop (from diapers) of healthy one year old Danish children and found more than 10,000 new virus species! The overwhelming majority of the viruses are phages, which are viruses that attack and inhabit bacteria. There were many more viruses than bacteria in the baby poop.

Most of the phages are harmless, but some others are not so harmless, and this results in immune responses from the human host. In other words, all of this is normal and part of "training" the immune system in early childhood. The researchers named the newly discovered viruses after children participating in the study (e.g., Amandaviridae, Andyviridae).

By the way, it is normal for multitudes of viruses, bacteria, and fungi to live in the gut of humans throughout life - it's the gut microbiome.

Excerpts from Washington Post: Scientists identify thousands of unknown viruses in babies’ diapers

Research involving Danish babies’ dirty diapers has provided a plethora of information on previously unknown viruses — and the best view yet of the makeup of the infant gut microbiome. ...continue reading "Healthy Babies Have Thousands of Viruses In The Gut"

Published on Leave a comment on The Microbiome of the Male Urethra

By now no one should be surprised that the male urethra has a microbiome - the community of microbes (bacteria, viruses, fungi) that live there. After all, we have millions of microbes living all over and in us.

There is the core microbiome generally found in all adult male urethras and then also microbes that vary from person to person. The urethra is the tube through which both urine and semen leave the male body.

A recent study found that having sex with a woman (vaginal sex) influences what lives in the male urethral microbiome. The researchers found that some of the men had microbes in the male urethra that are normally found in the female reproductive tract, specifically women with vaginal dysbiosis (yeast infections). This means the women transmitted the microbes to the men during sex. These microbes are not part of the male core urethral microbiome.

Interestingly, even if the men have microbes associated with bacterial vaginosis in the microbiome of the urethra, the men (unlike the women) didn't have any symptoms of an infection.

From Futurity: Vaginal infections can be sexually transmitted to men 

New research finds that the bacteria that causes a common vaginal infection can also have a major presence in men and can be sexually transmitted. ...continue reading "The Microbiome of the Male Urethra"

Published on Leave a comment on Group of Researchers Claim That the Fetus Does Not Have A Microbiome

Whether a developing baby (the fetus) has a microbiome or whether it is sterile during pregnancy and only gets "seeded" by microbes from the mother during birth is still being hotly debated. For years it was thought that the fetus and placenta were sterile (no microbes), but then several studies said there is evidence for the fetus and placenta having a microbiome (community of microbes).

Recently an international group of researchers stated that NO, there is no fetal microbiome. They reviewed current evidence, and according to their opinion - a healthy fetus is sterile. Instead, they suggest that the  microbes some researchers found were due to contamination when the samples were taken or during analysis.

We'll see how this all develops. Science is always evolving, with new findings, and lots of debate and controversy.

From Medical Xpress: Expert analysis refutes claims that humans are colonized by bacteria before birth

Scientific claims that babies harbor live bacteria while still in the womb are inaccurate, and may have impeded research progress, according to University College Cork (UCC) researchers at APC Microbiome Ireland, a world-leading Science Foundation Ireland (SFI) Research Center, which led a perspective published today in the journal Nature. ...continue reading "Group of Researchers Claim That the Fetus Does Not Have A Microbiome"

Published on Leave a comment on Almonds Are Good For You

Eating nuts is good for your health. A study conducted in the UK found that eating either a handful (56 grams) of whole or ground almonds every day for 4 weeks significantly increased the production of butyrate, a short-chain fatty acid that promotes gut health.

The study participants were persons eating a typical Western diet - low in fiber (less than the recommended amount), and with daily unhealthy snacks (chips, crisps, candy). The control group ate a muffin instead of almonds, and showed no improvements over the 4 weeks of the study. None of the 3 groups had significant changes at the microbiome level, which wasn't surprising because the rest of their diets stayed the same.

In other words, in a person who normally eats a typical Western diet - eating an additional handful of nuts daily helps with butyrate production (good!) and provides extra nutrients. But it's not enough of a dietary change to have a significant effect on the microbiome. For gut microbiome improvement need to add some fermented foods and more fruits, vegetables, whole grains, seeds, legumes, and nuts.

From Science Daily: Snacking on almonds boosts gut health, study finds

Eating a handful of almonds a day significantly increases the production of butyrate, a short-chain fatty acid that promotes gut health. ...continue reading "Almonds Are Good For You"

Published on Leave a comment on Studies Find Fungi In Cancer Tumors

We all know that microbes (fungi, viruses, bacteria) live throughout our bodies - this is the human microbiome or microbiota. What is really interesting is that cancer tumors also have microbiomes (tumor microbiome), and these microbial communities are different than that found in healthy people (without tumors).

For a while it has been known that tumors (e.g., breast cancers) have different bacterial species than healthy tissue - the microbiome is different. Several recent studies find that tumors can also contain fungi, and cancers with certain fungal species have worse outcomes than those without the fungi. The mycobiome is the community of fungi that live in or on humans.

Also, the combination of fungal species are different depending on what kind of cancer that a person has. A group of scientists have put together a list (mycobiome atlas) of the distinctive fungi that are found with 35 different cancer tumors. This is exciting because in the future cancers could potentially be found by the microbial (fungi and bacteria) DNA they shed in the blood.

However, no one knows really why the fungi are in the tumors. For example, are they aiding the cancer development? Or is the cancer allowing the fungi to grow? Are the fungi interacting with the immune system? Or??

Several recent articles discuss this exciting new research.

From NY Times: A New Approach to Spotting Tumors: Look for Their Microbes

Look up an image of a tumor on Google, and you’ll probably end up with a brightly colored cluster of cancer cells on a drab background of healthy tissue. But for Lian Narunsky Haziza, a cancer biologist at the Weizmann Institute of Science in Israel, the picture looks very different. A tumor may also contain millions of microbes, representing dozens of species.

Scientists have long known that our bodies are home to microbes, but have tended to treat tumors as if they were sterile. In recent years, however, researchers have laid that notion to rest, demonstrating that tumors are rife with microbes. ...continue reading "Studies Find Fungi In Cancer Tumors"

Published on Leave a comment on Sugar Substitutes Alter Gut Microbiome

All of us want to have a healthy gut microbiome (the microbial community of viruses, fungi, and bacteria). For health reasons many people try to lower their intake of sugars. However, ingesting artificial or non-nutritive sweeteners such as stevia, sucralose, aspartame, or saccharin may also have an effect on the body.

A recent study in both humans and mice found that these sugar substitutes cause gut microbiome changes and had an effect on a person's glycemic response (blood sugar levels). Saccharin and sucralose significantly impaired glucose tolerance in healthy adults - it impacted their glycemic response even at doses below FDA allowances (average daily intake or ADI).

The non-nutritive sweeteners also had an effect on the oral (mouth) microbiome. Each sweetener had a different and distinct effect on both oral and gut microbiomes. And the effects varied in each person, due to everyone having a different (unique) microbiome.

Earlier studies found negative health effects from sugar substitutes (e.g., higher incidence of diabetes, higher risk of cancer, gut microbiome changes). So be cautious until more is known. One of this study's researchers suggested drinking only water.

From Medical Xpress: Non-nutritive sweeteners affect human microbiomes and can alter glycemic responses

Since the late 1800s non-nutritive sweeteners have promised to deliver all the sweetness of sugar with none of the calories. They have long been believed to have no effect on the human body, but researchers publishing in the journal Cell on August 19 challenge this notion by finding that these sugar substitutes are not inert, and, in fact, some can alter human consumers' microbiomes in a way that can change their blood sugar levels. ...continue reading "Sugar Substitutes Alter Gut Microbiome"

Published on Leave a comment on The Foods We Eat Contain Live Microbes
Credit: Wikipedia

Every month there is more evidence of the importance of the human microbiome or microbiota - the community of microbes that live in and on us. Trillions of microbes! When we eat food, we eat all the microbes that are in the food, and this has effects on the microbes living in the gut (intestines).

How many microbes do we eat daily? An interesting study was published in 2014 that tried to answer this question. The researchers found that the average American adult ingests between 1 million to over 1 billion microbes every day! It depended on food choices.

Another study just published looked at more than 9000 foods in the US health and dietary database (from 74,466 persons). The researchers estimated the number of live microbes present in all the foods. From that they estimated that the intakes of foods with live microbes were pretty low (about 85 grams/day for children and 127 grams/day for adults). Their results were similar to the earlier 2014 study mentioned above.

They found that around 20% of children and 26% of adults consumed foods with high levels of live microorganisms in their diet. Also, American children and adults have steadily increased their consumption of foods with live microbes over an 18 year period of time - but it still didn't meet guidelines.

The researchers found that fruits, vegetables, and fermented dairy foods were the main sources of microbes, as well as 3 important nutrients which Americans generally do not get enough of: calcium, fiber, and potassium. They also mention that fruits and vegetables have more diverse microbes than fermented dairy foods (yogurts have mainly lactic acid bacteria).

Bottom line: Eating a diet rich in fruits, vegetables, and live fermented foods (e.g., yogurt, kefir, fermented pickles, and kimchi) are good ways to increase the number and variety of microbes in your diet. This study did not mention organic foods, but some studies have found more beneficial bacteria in organic produce (e.g., apples).

From Medical Xpress: Quantifying the live microbes on your plate

Many have hypothesized that bacteria and other "friendly" live microorganisms consumed through the diet can play an important role in health. Reduction in dietary microbe consumption has likely contributed to an "impoverished" gut microbiota, which may lead to improper immune system development and an increase in chronic diseases, among other negative health outcomes. ...continue reading "The Foods We Eat Contain Live Microbes"

Published on Leave a comment on Antibiotics Alter Gut Microbes In Young Infants

Many studies show that antibiotics disrupt the gut microbiome (intestinal microbial community of bacteria, viruses, fungi) in adults, but what about infants? A recent study found alterations in the gut microbes of young babies from a single course of antibiotics, with an increase in fungal species. And 6 weeks later the gut microbial community still wasn't back to normal. Yikes.

Antibiotics can be life-saving, but they must be used carefully - only when needed. As research shows, when some microbes are killed off by antibiotics, then other microbes (e.g. fungi such as Candida) that are resistant to the antibiotics increase (multiply) and move into the vacated spaces. There are no empty spaces in the gut.

Babies normally have a variety of fungal species in the gut already at a very young age - and this community of fungi is called the gut mycobiota or mycobiome. The Univ. of Helsinki researchers concluded that normally bacteria control fungi numbers in the gut - there is balance of all sorts of microbes (bacteria, viruses, fungi). But if you kill off bacteria (with antibiotics), then fungi numbers increase - an example of an imbalance in the gut microbial community or dysbiosis.

From Science Daily: A single course of antibiotics affects the gut microbiota of infants

A study recently completed at the University of Helsinki revealed that the fungal microbiota in the gut is more abundant and diverse in children treated with antibiotics compared with the control group even six weeks following the start of the antibiotic course. In light of the findings, a reduction in the number of gut bacteria as a result of antibiotic therapy reduces competition for space and leaves more room for fungi to multiply. ...continue reading "Antibiotics Alter Gut Microbes In Young Infants"