BPA is in many consumer products, but research is finding more and more problems with it. The findings of these two studies may motivate people to try to lower their exposure to plastics and BPA. From Newsweek:
Bisphenol-A is everywhere. If you are reading this in the United States, there is a greater-than-90 percent chance you have BPA in your system, according to the Centers for Disease Control. The chemical is nearly ubiquitous: it is all over your receipts and soup cans, and it gives plastic bottles useful properties like flexibility and durability. It also mimics human estrogen in the body, and studies have linked it to breast cancer, diabetes, obesity, and hormone abnormalities in children, though what doses are dangerous is a matter of debate.
Now, for the first time, scientists are adding prostate cancer to the list of possible health problems from exposure.
Prostate cancer is the second most prevalent form of cancer among men, afflicting one in six, mostly later in life. A new study published Monday in the journal Plos One found that men with prostate cancer have BPA in their urine at levels 2- to 4-fold higher than cancer-free men. Aging is the best-known risk for prostate cancer, which makes the study’s findings particularly salient: BPA concentrations were especially high in prostate cancer patients under the age of 40, when aging is less of a contributing factor to the development of prostate cancer.
From Science Daily:
UT Arlington biochemists say their newly published study brings researchers a step closer to understanding how the commonly used synthetic compound bisphenol-A, or BPA, may promote breast cancer growth.
Subhrangsu Mandal, associate professor of chemistry/biochemistry, and Arunoday Bhan, a PhD student in Mandal's lab, looked at a molecule called RNA HOTAIR. HOTAIR is an abbreviation for long, non-coding RNA, a part of DNA in humans and other vertebrates. HOTAIR does not produce a protein on its own but, when it is being expressed or functioning, it can suppress genes that would normally slow tumor growth or cause cancer cell death.
High levels of HOTAIR expression have been linked to breast tumors, pancreatic and colorectal cancers, sarcoma and others.
UT Arlington researchers found that when breast cancer and mammary gland cells were exposed to BPA in lab tests, the BPA worked together with naturally present molecules, including estrogen, to create abnormal amounts of HOTAIR expression.
"We were surprised to find that BPA not only increased HOTAIR in tumor cells but also in normal breast tissue," said Bhan. He said further research is needed, but the results beg the question -- are BPA and HOTAIR involved in tumor genesis in addition to tumor growth?
BPA has been widely used in plastics, such as food storage containers, the lining of canned goods and, until recently, baby bottles. It belongs to a class of endocrine disrupting chemicals, or EDCs, which have been shown to mimic natural hormones. These endocrine disruptors interfere with hormone regulation and proper function of human cells, glands and tissue.