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Published on Leave a comment on Oral Vaccine for Recurrent Urinary Tract Infections
E. coli bacteria Credit: NIAID

Soon there may be an oral vaccine for recurrent urinary tract infections (UTIs). That is wonderful news for millions of women suffering from frequent urinary tract infections, who wind up taking repeated courses of antibiotics. Yet they keep getting UTIs.

In a small study, 54% of the persons who took the vaccine remained UTI free for the entire 9 year follow-up period, with the average UTI free period in the group (72 women and 17 men) of 4 1/2 years. The researchers said the results were a "game-changer" for the study participants.

In this study, the vaccine was given "off label" in the UK. 40% of the group had repeated doses after 1 or 2 years. Please view the study as having preliminary results, especially because the study did not have a control group that didn't receive the vaccine. There were no notable adverse effects from the vaccine .

The vaccine, called Uromune (MV140), was developed by Immunotek in Spain. The vaccine is composed of inactivated whole bacteria commonly associated with UTIs: E.coli, K. pneumoniae, P. vulgaris, and E. faecalis. It is taken every day - 2 sprays of a pineapple flavored liquid under the tongue for three months.

The vaccine is not approved by the FDA in the US at this time. It is currently pending approval in Canada and available off-license in 26 countries, including Mexico. Clinical trials are now going on. It has been in use for several years (more than 40,000 patients).

What to do now? While you're waiting for US FDA vaccine approval, why not try D-mannose for UTIs? It's non-prescription, safe, available as capsule or powder, works well for most species implicated in UTIs (such as E. coli),  and readily available. Studies support its use as either a preventive or a treatment for UTIs, and as a replacement for antibiotics.

The vaccine results were recently presented at a European medical conference. From Medical Xpress: Oral vaccine for UTI is potential alternative to antibiotics, finds 9-year study

Recurrent Urinary Tract Infections (UTIs) can be prevented for up to nine years in more than half of people given an oral spray-based vaccine and is a potential alternative to antibiotic treatments, finds research. ...continue reading "Oral Vaccine for Recurrent Urinary Tract Infections"

Published on Leave a comment on Get A Good Night’s Sleep After Getting Vaccinated

It has been known for a while that getting a good night's sleep after getting vaccinated results in a stronger immune response. Twice as strong response! A recent study suggests that this could be due to beneficial T-cells (which are part of immune system) migrating toward the lymph nodes during sleep.

Growth hormone and prolactin are both involved in the migrating response.

Similarly, many studies find that having a short sleep duration (less than 6 hours) after a vaccination reduces the immune antibody response.

Bottom line: If you want a good antibody/immune response to a vaccine - get a good night's sleep of 6 or more hours after being vaccinated! Good sleep stimulates the immune system.

From Science Daily: Immunology: Good sleep stimulates the immune system

Sleep is healthy -- this popular knowledge is backed by science.

Previous research had already shown that in people who slept after a vaccination, the immune response was twice as strong on average as in people who did not sleep during the night after the vaccination. However, the cell biological reasons for this had been little investigated before now.

...continue reading "Get A Good Night’s Sleep After Getting Vaccinated"

Published on Leave a comment on Waiting For A Lyme Disease Vaccine
Deer tick Credit: Wikipedia

Will we soon have vaccines to protect us from Lyme disease? It turns out that there are two possible vaccines being tested right now, including one based on mRNA technologies (same as the Covid vaccines).

The mRNA vaccine has has been successfully tested in mice so far, and yes - it protected the mice from being infected with the bacterium Borrelia burgdorferi which causes Lyme disease. The second one is an intranasal protein vaccine (an established vaccine type) and is currently being tested on humans. But both vaccines are a while off yet.

Meanwhile, we're all waiting, waiting, waiting for a Lyme disease vaccine.

Excerpts from The Scientist - Newly Developed mRNA Vaccine Protects Against Lyme Disease

After walking through a forest or field of tall grass, public health agencies in many countries advise people to check their clothes, pets, and bodies for unwanted hitchhikers—ticks. These arthropods feed on the blood of mammals, such as mice, deer, livestock, and humans, as well as lizards and birds.1 Additionally, Ixodes ticks act as vectors, where they transfer disease-causing bacteria, viruses, or protozoa to their host during feeding. ...continue reading "Waiting For A Lyme Disease Vaccine"

Published on Leave a comment on Breast Cancer Vaccine Now Being Tested
Normal (left) vs cancerous breast (right), mammography image
Credit: National Cancer Institute

This is very preliminary, but everyone is excited over a breast cancer vaccine now being tested. The vaccine is meant to treat women who have breast cancer.

University of Washington researchers tested the vaccine for safety (it was very safe) and to see what was a good dose for women in a Phase 1 Clinical Trial. But the 66 women it was tested on (all who had metastatic breast cancer that had been treated) overall did much better than expected. Fabulous!

The next trial will soon start (Phase 2) with women at different stages of breast cancer. Stay tuned!

From Medical Xpress: Breast cancer vaccine safely generates anti-tumor immunity

An experimental vaccine against breast cancer safely generated a strong immune response to a key tumor protein, researchers from the University of Washington School of Medicine in Seattle report in a paper published by the journal JAMA Oncology. The findings suggest the vaccine may be able to treat different types of breast cancer.

"Because this was not a randomized clinical trial, the results should be considered preliminary, but the findings are promising enough that the vaccine will now be evaluated in a larger, randomized clinical trial," said lead author Dr. Mary "Nora" L. Disis, a UW professor of medicine, Division of Medical Oncology, and director of the Cancer Vaccine Institute. ...continue reading "Breast Cancer Vaccine Now Being Tested"

Published on Leave a comment on HPV Vaccine Success Story

The HPV vaccine has been amazingly successful in reducing cases of cervical cancer. Researchers in the UK recently  reported that there are 87% fewer cervical cancers among women who were part of the first mass vaccination program against human papillomavirus (HPV), compared to women of previous generations. A vaccine success story!

Initially the vaccine Cervarix was administered in the HPV vaccination program, which started in 2008 in England. The Cervarix vaccine is effective against HPV 16 and 18, the strains which are responsible for 70% to 80% of all cervical cancers. In 2012 they switched to the HPV vaccine Gardasil, which is effective against two additional HPV types - HPV 6 and 11.

Researchers looked at the incidence of both cervical cancer and noninvasive cervical carcinoma (grade 3 cervical intraepithelial neoplasia or CIN3, which frequently progresses to cancer) in England between January 2006 and June 2019.

They found that girls who received the vaccine between 12 to 13 years of age had a cervical  cancer rate 87% lower than expected in a nonvaccinated population, and the rate of noninvasive cervical carcinoma (CIN3) was 97% lower than expected. Those who were vaccinated between the ages of 14 and 16 years had a 62% reduction in cervical cancer and 75% for CIN3. Those vaccinated between the ages of 16 and 18 years had a 34% reduction in cervical cancer and 39% in CIN3.

The authors point out that this is still a developing story - that since the women are still relatively young, we don't know the full impact of the HPV vaccination on cervical cancer rates. But they expect it to be impressive over time.

Excerpts from Medscape: Success of HPV Vaccination: 'Dramatic' Reduction in Cervical Cancer

New data from England show the success of the national program for vaccinating girls against human papillomavirus (HPV) to prevent cervical cancer.  ...continue reading "HPV Vaccine Success Story"

Published on Leave a comment on Encouraging Results For A Vaccine Targeting Brain Tumors

The possibility of a vaccine for helping the body fight cancer just got one step closer. A vaccine that targets a specific type of usually incurable brain cancer called "diffuse glioma" has had very good results in a trial of the vaccine. This is great news for a brain cancer that, even with treatment, keeps spreading throughout the brain, and only has a general 5-year survival rate of 48.9%.

The most important findings of the vaccine trial: the 3 year survival rate after being fully vaccinated was 84%, and in this group of 30 patients - 63% did not have any progression in tumor growth. And 82% of one subgroup of patients whose immune system showed a specific response to the vaccines had no tumor progression within the 3 year study period. This is amazing news for a cancer that typically has such a bleak prognosis.

brain cancer, diffuse glioma
Diffuse glioma in the brain. Credit: NCI

In a follow-up to this trial the researchers are combining the vaccine with checkpoint inhibitor immunotherapy (which give the immune system a boost), and which they think (are hoping) may produce even better results. Think of it this way - these treatments have the potential for you (your body's immune system) to effectively fight a cancer. The future is looking bright!

From Medical Xpress: First-ever vaccine for malignant brain tumors reported safe, effective in early trial

Tumor vaccines can help the body fight cancer. Mutations in the tumor genome often lead to protein changes that are typical of cancer. A vaccine can alert the patient's immune system to these mutated proteins. For the first time, physicians and cancer researchers from Heidelberg and Mannheim have now carried out a clinical trial to test a mutation-specific vaccine against malignant brain tumors. The vaccine proved to be safe and triggered the desired immune response in the tumor tissue, as the team now reports in the journal Nature.  ...continue reading "Encouraging Results For A Vaccine Targeting Brain Tumors"

Published on Leave a comment on Pregnant Women and COVID-19 Vaccines

There is much debate over whether pregnant women should get a COVID-19 vaccine. This is because studies of pregnant women receiving vaccinations have not been done, and so risks and possible harms (if any) are unknown. But what is known is that pregnant women are at higher risk for pregnancy complications if they get COVID-19 (e.g. increased risk of preterm labor and stillbirth).

Pregnant women getting the vaccine are essentially part of an experiment looking at the vaccine's safety for both the pregnancy and the developing baby. But finally a case study (one woman!) has been published.

The good news is that results look promising. Antibodies from the vaccinated mother crossed the placenta and reached the baby. The pregnant woman had received the Moderna vaccine at 36 weeks, she delivered the healthy baby at 39 weeks, and antibodies against the virus were found in the umbilical cord blood - which meant they had been transferred from the mother to the baby.

A related study (see below) also gives hope that it may be beneficial for pregnant women to get vaccinated - at least 17 days before the birth so that antibodies can build up.

Excerpts from The Scientist: COVID-19 Vaccines for Pregnant Moms May Protect Newborns

Pregnant women with COVID-19 are at an increased risk for severe illness and death compared to people with COVID-19 who are not pregnant, and they experience preterm birth and pregnancy loss more frequently than do expecting moms who don’t catch the virus. In spite of these risks, there is no clear guidance available yet for vaccinating pregnant women against COVID-19. But there is now some evidence that immunization could protect their newborns. For the first time, doctors report that SARS-CoV-2 antibodies from a vaccinated mother can cross the placenta, pointing to a likely benefit for her fetus.  ...continue reading "Pregnant Women and COVID-19 Vaccines"