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Category: cancer

Published on Leave a comment on Another Vitamin D Study With Disappointing Results

Recently, another well done study of vitamin D and cancer resulted in disappointing results. Vitamin D supplements showed no benefit in persons with metastatic colorectal cancer (CRC). It did not result in a difference in overall survival outcomes.

In the study, 455 patients with metastatic colorectal cancer were assigned randomly to either high daily vitamin D3 or standard dose vitamin D3, in addition to receiving standard chemotherapy. The high dose vitamin D group received a loading dose of 8000 IU per day for 2 weeks, followed by a maintenance dose of 4000 IU per day until the end of the study. The standard dose vitamin D group received 400 IU per day.

However, there was no difference in "significant progression-free survival benefit". There also was no significant difference in how long people survived in the 2 groups (a median of 25.6 months in the high-dose group, and 27.0 months in the standard dose group).

The study results were disappointing because in laboratory studies vitamin D has anticancer properties. Critics of this study pointed out that vitamin D supplementation may have a role in cancer prevention - but at this point, that is unknown.

From Medscape: High-Dose Vitamin D Disappoints in Metastatic CRC: SOLARIS

The addition of high-dose vitamin D supplementation to standard chemotherapy plus bevacizumab did not result in a significant progression-free survival benefit in patients with metastatic colorectal cancer (CRC) in the SOLARIS study. ...continue reading "Another Vitamin D Study With Disappointing Results"

Published on Leave a comment on A Promising Antibiotic For Gum Disease

The bacteria Fusobacterium nucleatum is prevalent in periodontal disease (gum disease), but also in some chronic diseases and cancers, such as colorectal cancer. The bacteria F. nucleatum is normally found in the mouth (oral) microbiome, and its numbers increase as periodontal disease inflammation increases.

It is thought that sometimes the bacteria leaves the mouth and travels to other parts of the body, where it can promote cancer and other diseases.

A recent study found that the antibiotic FP 100 (Hygromycin A) totally eliminates the F. nucleatum bacteria in the mouth, and without causing harm to the mouth microbiome or gut microbiome. This is because it is a narrow spectrum antibiotic - only targets the harmful bacteria, and not all (both good and harmful) bacteria. While the study was only done in mice, this is promising and welcome news.

Eliminating the harmful bacteria in the mouth would potentially prevent some chronic diseases and cancers. Now we need further studies to see if this finding holds up in humans.

From Medical Xpress: First narrow-spectrum antibiotic successfully eliminates  Fusobacterium nucleatum, a gum disease pathogen

In a study published in the Journal of Oral Microbiology, ADA Forsyth scientists found that FP 100 (Hygromycin A), a first-in-class, small molecule, narrow-spectrum antibiotic, successfully eradicates Fusobacterium nucleatum without harming the oral or gut microbiomes. ...continue reading "A Promising Antibiotic For Gum Disease"

Published on Leave a comment on Tobacco Smoke, Bladder Cancer, and the Gut Microbiome

The microbes living on and in us (the human microbiome or microbiota) play a big role in our health. Certain microbes are even implicated in cancer development and progression. Thus, it shouldn't come as a surprise that new research finds that certain bacteria are linked with bladder cancer.

It has long been known that certain nitrosamine compounds, which are in tobacco smoke, can induce bladder cancer - both in humans and rodents (e.g., mice). Nitrosamines are carcinogenic (cancer causing).

The study was done with mice given nitrosamine compounds (in their drinking water) for 12 weeks. The interesting part was that if antibiotics were given at the same time to the mice, bladder cancer did not develop in most of those mice. But it did develop in most of the mice not given antibiotics.

Since antibiotics reduce the number of bacteria in the gut, this means that gut microbes play a part in the bladder tumor onset. The researchers did find 12 bacterial species that they thought played a role in the mice, but it is unknown whether the same or different species play a role in human bladder cancer onset.

Will the use of antibiotics prevent bladder cancer also in humans? Stay tuned..

From Medical Xpress: Gut microbes implicated in bladder cancer

At any given time, over 10 trillion microbes call our guts their home. From breaking down nutrients in our food to strengthening our immunity against pathogens, these microbes play an essential role in how we interact with the world. This includes—as shown in a new study by EMBL researchers and collaborators at the University of Split, Croatia—the way the body responds to carcinogens and develops cancer. ...continue reading "Tobacco Smoke, Bladder Cancer, and the Gut Microbiome"

Published on Leave a comment on A Mediterranean Style Diet Feeds Beneficial Gut Bacteria

The incidence of both intestinal bowel diseases (IBD) and colorectal cancer is rapidly increasing in developed countries (e.g., US, Canada, Europe). There are many theories over why this is occurring, with most researchers thinking a person's diet plays a role. A big suspect in promoting IBD and colorectal cancer is the Western diet, which has lots of ultra-processed foods and is also low in fiber.

A recent large study looked at 6 major diets and how they impact the gut microbiome. The six dietary patterns were: Western diet, Mediterranean diet, high-fiber diet, plant-based diet, high protein diet, and ketogenic diet.

And surprise, surprise - eating a Western diet resulted in having an increase in gut bacterial species linked to chronic inflammation, heart disease, colorectal cancer, IBD, and diabetes. The Mediterranean style diet had an increase in bacterial species linked to a lower risk of cardiovascular disease, IBD, and type 2 diabetes. In fact, all 6 diets had distinct bacterial profiles in the gut.

Bottom line: The foods a person eats can either feed and nourish beneficial bacteria or harmful bacteria (linked to cancer and IBD). Best for health is a Mediterranean style diet (lots of fruits, vegetables, whole grains, legumes, seeds, nuts), and avoiding ultra-processed foods. You are what you eat!

From Medical Xpress: Western diets pose greater risk of cancer and inflammatory bowel disease, study finds

Western diets pose a greater risk of inflammatory bowel disease (IBD) and colorectal cancer, according to a milestone review of what people eat around the world. ...continue reading "A Mediterranean Style Diet Feeds Beneficial Gut Bacteria"

Published on Leave a comment on Aspirin and Lower Risk of Colorectal Cancer

Studies on aspirin keep coming. For decades, studies found that persons taking aspirin frequently have a lowered risk of developing colorectal (colon) cancer, and that they are less likely to die if they do develop colorectal cancer. A recent study confirmed these aspirin findings and looked at what is occurring.

Aspirin appears to boost or activate the immune system, which helps explain its protective effect in colorectal cancer. Clinical trials are going on now to test whether and how aspirin can be part of colorectal cancer treatment.

From Medscape: How Aspirin May Lower Risk for Colorectal Cancer

A 2020 meta-analysis, for instance, found that 325 mg of daily aspirin — the typical dose in a single tablet — conferred a 35% reduced risk of developing CRC, and a highly cited The Lancet study from 2010 found that a low dose of daily aspirin reduced the incidence of colon cancer by 24% and colon cancer deaths by 35% over 20 years.

The evidence surrounding aspirin and CRC is so intriguing that more than 70,000 people are currently participating in more than 2 dozen clinical studies worldwide, putting aspirin through its paces as an intervention in CRC.

But what, exactly, is aspirin doing?

...continue reading "Aspirin and Lower Risk of Colorectal Cancer"

Published on Leave a comment on Tattoos and Increased Risk of Cancer?
Tattoo Credit: Wikipedia

There has always been some concern about whether there are health effects from tattoos, especially ones that cover a large area of skin. Tattoo inks contain heavy metals, colors, nanoparticles, and all sorts of other chemicals, including carcinogens. A recent study conducted in Sweden found an increased risk of malignant lymphoma in persons with tattoos, specifically a 21% higher risk.

It has been known for years that tattoos cause chronic inflammation, and that nanoparticles from the inks travel throughout the body, including lymph nodes. It is thought that perhaps the low grade chronic inflammation from the tattoo is causing an increased risk for cancer in the lymphatic system, such as malignant lymphoma. Interestingly, in the study, the size of the tattoo did not increase the risk - it didn't seem to matter.

By the way, in this large study, 21% of individuals with malignant lymphoma had tattoos, but18% of persons who did not get malignant lymphoma also had tattoos. So... if you have a tattoo, it does not mean you'll definitely get lymphoma - it just increases the risk.

From Medical Xpress: Possible association between tattoos and lymphoma revealed

Our knowledge regarding the long-term health effects of tattoos is currently poor, and there is not a lot of research within this area. Now a research group at Lund University has investigated the association between tattoos and lymphoma. ...continue reading "Tattoos and Increased Risk of Cancer?"

Published on Leave a comment on A Specific Bacteria and Colorectal Cancer
Credit: Wikipedia

Cancer tumors have a different microbiome (community of microbes) than healthy tissue. Researchers have been finding the bacteria Fusobacterium nucleatum (F. nucleatum) in a number of cancers, with high levels of its presence associated with a poorer outcome for the person (more metastases and death).

A recent study found that one strain or subtype of  F. nucleatum (called Fna C2)  is found in tumors of about 50% of aggressive colon cancers.

Interestingly, F. nucleatum is a normal oral bacteria - one found in the mouth of people, and also associated with periodontal disease. It is rarely found in the gastrointestinal (GI) tract of healthy persons.

It is thought that the bacteria somehow travels from the mouth to the stomach, where it can withstand stomach acid, and then grows there in the gastrointestinal tract. F. nucleatum is cancer promoting - for example, it has a supporting role in tumor progression. It appears to be resistant to cancer treatments.

Researchers are now wondering if certain beneficial or good bacteria ingested by the person or somehow delivered to the tumor site  can battle the F. nucleatum, perhaps as part of cancer therapy. Stay tuned....

From Science Daily: Bacteria subtype linked to growth in up to 50% of human colorectal cancers

Researchers at Fred Hutchinson Cancer Center have found that a specific subtype of a microbe commonly found in the mouth is able to travel to the gut and grow within colorectal cancer tumors. This microbe is also a culprit for driving cancer progression and leads to poorer patient outcomes after cancer treatment. ...continue reading "A Specific Bacteria and Colorectal Cancer"

Published on Leave a comment on Promising New Approach For Treating Deadly Brain Cancers

There may be new treatments on the horizon for the most aggressive and deadly brain cancer known as glioblastoma. The median survival is less than one year, so this is very exciting news.

Two studies, using slightly different approaches, were tested on a very small number of patients (3 in one study, 6 in the other). Both approaches used the patient's own modified T-cells (part of immune system) to attack the brain tumor. Initially there was amazing shrinkage of the tumors, but unfortunately this effect was only temporary for most.

The ultimate goal is to make treatments that have long-lasting effects. By the way, glioblastoma is the brain cancer that killed President's son Beau, as well as Arizona Senator John McCain.

[Click on the article link to see amazing MRI scan images of brain tumor shrinkage.] From Medical Xpress: A new strategy to attack aggressive brain cancer shrank tumors in two early tests

Scientists took patients' own immune cells and turned them into "living drugs" able to recognize and attack glioblastoma. In the first-step tests, those cells shrank tumors at least temporarily, researchers reported Wednesday. ...continue reading "Promising New Approach For Treating Deadly Brain Cancers"

Published on Leave a comment on Food Additives and Higher Cancer Risk

Most Americans eat highly processed or ultra-processed foods every single day, with most of their daily calories from them! There are all sorts of health risks from these foods, with a recent study finding an overall increased risk of cancer, as well as prostate and breast cancer.

Emulsifiers are food additives found in many ultra-processed foods. A large French study found that higher intakes of the emulsifiers carrageenan, mono and diglycerides are linked to an overall increased risk of cancer, as well as an increased risk in prostate and breast cancers.

Bottom line: Read the ingredients listed on labels! As much as possible, try to only buy and cook foods with ingredients that you would find in a kitchen. For example, flour, sugar - yes, chemical sounding names - no.

From Medscape: Are Food Emulsifiers Associated With Increased Cancer Risk?

...continue reading "Food Additives and Higher Cancer Risk"

Published on Leave a comment on Benefits of a Plant-Based Diet For Men With Prostate Cancer

A recent study reports more good news about eating a plant-based diet - that is, one rich in fruits, vegetables, whole grains, nuts, legumes, seeds, but low in meat and dairy foods.

Researchers found that in men who had already been diagnosed with prostate cancer, those eating the most plant-based foods had the least erectile dysfunction, urinary incontinence, urinary irritation, and had better "hormonal health and vitality" (e.g., symptoms such as low energy, depression, and hot flashes). Consuming more plant-based foods was associated with better sexual and bowel function (this last from the fiber in plant-based foods).

Other research already shows that plant-based diets can reduce the risk of prostate cancer, as well as for prostate cancer recurrence and for the cancer progressing. A reason for this could be because a plant-based diet (e.g., Mediterranean style diet) lowers chronic inflammation.

From Medical Xpress: Plant-based diet tied to improved sexual health in men treated for prostate cancer

A diet that limits meat and dairy but is rich in fruits, vegetables, grains, and nuts is linked to less erectile dysfunction, urinary incontinence, and other common side effects seen in prostate cancer patients, a new study shows. ...continue reading "Benefits of a Plant-Based Diet For Men With Prostate Cancer"