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Category: pregnancy and childbirth

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Most people know that heavy drinking of alcohol, smoking marijuana, cigarette smoking, and using methamphetamine during pregnancy should be avoided because they can have negative effects on the developing fetus. However, this study found that each of these also had a distinct negative effect on the placenta, suggesting that "different mechanisms mediate their effects on placental development". From Science Daily:

Effects of alcohol, methamphetamine, and marijuana exposure on the placenta

In the United States, prenatal alcohol exposure (PAE) is the most common preventable cause of developmental delay. Animal studies have shown some of the adverse effects of PAE on placental development, but few studies have examined these effects in humans. This is the first study to examine the effects of prenatal exposure to methamphetamine, marijuana, and cigarette smoking on human placental development.

Researchers collected placentas from 103 Cape Coloured (mixed ancestry) pregnant women recruited at their first antenatal clinic visit in Cape Town, South Africa. Of these, 66 heavy drinkers and 37 non-drinkers were interviewed about their alcohol, cigarette smoking, and drug use at three antenatal visits. A senior pathologist, blinded to exposure status, performed comprehensive pathology examinations on each placenta using a standardized protocol. In multivariable regression models, effects of prenatal exposure were examined on placental size, structure, and presence of infections and meconium.

Results show that alcohol, methamphetamine, and marijuana were associated with distinct patterns of pathology, suggesting that different mechanisms mediate their effects on placental development. Alcohol exposure was related to decreased placental weight and a smaller placenta-to-birth weight ratio. By contrast, methamphetamine was associated with larger placental weight and a larger placenta-to-birth weight ratio. Marijuana was also associated with larger placental weight. In addition, alcohol exposure was associated with an increased risk of placental hemorrhage. Finally, alcohol and cigarette smoking were associated with a decreased risk of intrauterine passing of meconium, a sign of acute fetal stress and/or hypoxia; methamphetamine, with an increased risk. These findings may be important in the long-term teratogenic effects of prenatal alcohol and drug exposure.

Published on Leave a comment on Dangers Persist With Nonstick Coatings

For years stores and manufacturers have promoted the advantages of Scotchgard and Teflon nonstick coatings for pots and pans, as stain-proofing for upholstered furniture and rugs, as a water repellent for clothing, for consumer goods such as dental floss, and for grease-proof food wrappers and containers. And yes, people have been convinced - with most cookware sold today being of the nonstick type, and the popularity of sofas and rugs coated with non-stain coatings. But once again, chemicals come with a price and health effects, and unfortunately these particular chemicals are found in all of us in varying levels.

Polyfluorinated chemicals (PFCs) are a class of chemicals that are stain, water, and grease repellent chemicals.They have been found in the blood of more than 98% of the United States population. PFCs stay in the environment and body for many years (thus labeled as "persistent"). Some PFCs: perfluorooctanoic acid, or PFOA, perfluorooctane sulfonate or PFOS, perfluorononanoic acid or PFNA, and perfluorohexane sulfonate or PFHxS.

PFOA was used to make DuPont's popular Teflon coating for decades. DuPont phased out its PFOA production after a settlement with federal regulators (it was linked it to birth defects and cancer in animals). But meanwhile PFOA spread worldwide, and traces of the compound have been found in most people, in polar bears in the Arctic, in some drinking water, and even in some fish. PFCs pass from mothers to their babies during pregnancy, and in breast milk after birth. They are considered hazardous even in small doses, they accumulate, and have been linked to all sorts of medical problems, from developmental delays in the fetus and child, to immune problems, kidney disease, kidney and testicular cancers, and to thyroid disease.

And once again, as some chemicals are phased out, the replacement chemicals may be just as bad. One group of replacement chemicals is perfluoroalkyl sulfonate (PFAS). Experts worry that this new group of PFASs has many of the same troubling characteristics as their predecessors, because of the chemical similarities with the original chemicals. But we won't know for years, because once again the necessary health tests have not been done.

What can you do to avoid PFCs? 1) Do not use Teflon or non-stick pots, pans, and utensils. Use stainless steel or cast iron instead. 2) Avoid Scotchgard or other stain-proofing or stain-resistant treatments on upholstered furniture or rugs. 3) Avoid jackets, rain gear, or other clothing with "water resistant" or "stain resistant" treatments. 4) Try to cut back on foods that come in "grease-proof" containers. Don't use microwave popcorn bags. 5) Don't use dental floss such as Oral-B Glide dental floss (uses PFC), and use unwaxed or natural wax floss instead (such as Toms of Maine floss). 6) Avoid personal care products that contain ingredients that include the words “fluoro” or “perfluoro.

From Medscape: Prenatal Exposure to Household Chemicals Hurts Kids' Cognition

Exposure to common household chemicals such as those found in nonstick cooking pans, upholstery, carpet pads, and electronics during pregnancy may lead to poorer cognitive and behavioral development during childhood, new research shows.

In an analysis of more than 250 mother-child pairs, maternal exposure to polybrominated diphenyl ethers (PBDEs) and perfluoroalkyl substances (PFASs) was associated with impairments in executive function in children aged 5 and 8 years. "These findings suggest that concentrations of maternal serum PBDEs and PFASs during pregnancy may be associated with poorer executive function in school-age children," the investigators, with first author Ann Vuong, DrPH,...."Given that the persistence of PBDEs and PFASs has resulted in detectable serum concentrations worldwide, the observed deficits in executive function may have a large impact at the population level," they add.

In-unit increases in PFOS levels were associated with worse behavior regulation, poorer metacognition, and poorer global executive functioning. No link was found between PFOA levels and executive function. Dr Vuong told Medscape Medical News that although the majority of PBDEs and PFASs have been phased out of products, there is an ongoing risk of exposure."It's in the environment, and probably it's that people have already purchased products within their homes, and everyone has [PBDEs] in their bodies. So the only way to reduce the body burden or exposure is through cleaning methods," she said.

For PBDEs, it is recommended that people regularly use a high-efficiency particulate air (HEPA) filter in their vacuum and that they wipe down surfaces and regularly wash their hands. "For PFASs, it's recommended that you try not to, or limit your use of, microwaved fast food packaging, as well as trying not to use deteriorated pans with nonstick coatings," Dr Vuong added....Although reducing exposure to substances with known neurodevelopmental and cognitive risks is important, Dr Vuong emphasized that the chemicals have been replaced by novel compounds, some of which may carry their own risks.

UPDATE: 2 new articles discussing this issue: New Teflon Toxin Causes Cancer in Lab Animals and How Dupont Concealed the Dangers of the New Teflon Toxin

Published on Leave a comment on Avoid the New Generation of Flame Retardants

Flame retardants. All around us, and in us. So, so hard to avoid because they're in electronic goods, in upholstered furniture, polyurethane foam, carpet pads, some textiles, the foam in baby items, house dust, building insulation, and on and on. And unfortunately, while a number of toxic flame retardants have been phased out, it appears that the new replacements may be just as bad and are more easily inhaled (the small particles go down the air tract and into the lung tissue).

What to do? Wash hands before eating. Try to use a vacuum cleaner with a HEPA filter. Try to avoid products that say they contain "flame retardants". Only buy upholstered furniture with tags that say they are flame retardant free. From Environmental Health News:

As Washington state decides on stronger toxics law, residents are breathing flame retardants

A new generation of chemicals added to furniture, building insulation and baby products like car seats to slow the spread of flames are escaping into air at higher levels than previously thought, according to a new study out of Washington state. The findings come as Washington lawmakers decide on bolstering flame retardant bans. The state was one of the first to ban an earlier generation of retardants, known as PBDEs.

The new research found flame retardant chemicals used to replace polybrominated diphenyl ethers (PBDEs) also escape, are ubiquitous in indoor air and suggest inhalation is a major route of exposure for people. The compounds, called chlorinated organophosphate flame retardants, found in the study have been linked to cancer and reproductive problems, and some can alter hormones essential for development. “We’ve been underestimating what total exposure is,” said Erika Schreder, staff scientist at the Washington Toxics Coalition and lead author of the study published this month in the scientific journal Chemosphere.

Researchers gave 10 people from Washington state an air sampler that simulates breathing to wear during a normal day: office work, commuting, hanging out at home. They tested for a suite of the new generation of chlorinated flame retardants and found all 10 were breathing some amount of them throughout the day. Exposure to one of the most prevalent compounds was up to 30 times greater than ingesting the chemicals via dust. The distinction is important: dust exposure occurs largely through the mouth, previously thought to be the major exposure route for banned PBDEs.

Chlorinated flame retardants are used mostly in polyurethane foam, often in building insulation and everyday products such as furniture, children’s car seats and baby strollers. The compounds are substitutes for PBDEs, which were widely used as flame retardants until scientists reported they were building up in people and wildlife and various bans took hold.

While chlorinated flame retardants have been around for decades, Salamova said scientists have recently started to understand them as, at first, it was thought they weren’t harmful or able to accumulate in people and wildlife. However there is evidence the replacement are following the same path as PBDEs: chlorinated flame retardants have been found in household dust, children’s products, drinking water, and mother-toddlers pairs. Two chlorinated flame retardants have been flagged by the state of California as carcinogens, and animal research suggests they may hamper brain development as well. 

From Medical Xpress: Prenatal exposure to flame retardants linked to poorer behavioral function in children

New research from the University of Cincinnati (UC) College of Medicine suggests that prenatal exposure to flame retardants and perfluoroalkyl substances (PFASs) commonly found in the environment may have a lasting effect on a child's cognitive and behavioral development, known as executive function...."We examined the relationship between prenatal exposure to PBDEs and PFASs and executive function in children at 5 and 8 years of age," said Ann Vuong, DrPH, a postdoctoral fellow at the University of Cincinnati in the Department of Environmental Health. "The findings suggest that maternal serum concentrations of PBDEs and perfluorooctane sulfonate (PFOS), one of the most commonly found PFASs in human blood, may be associated with poorer executive functioning in school-age children."

From Science Daily: Exposure to common flame retardants may contribute to attention problems in children

Prenatal exposure to some flame retardants that have been widely-used in consumer products is associated with attention problems in young children. A new study is the first to show the effects of prenatal exposure to polybrominated diphenyl ethers on children's development at ages 3, 4, and 7 years. Children with the highest exposure to certain PBDEs had approximately twice the number of maternally-reported attention problems compared to the other children in the study. PBDEs are found in textiles, plastics, wiring, and furniture containing polyurethane foam to reduce flammability.

Very nice and thorough report about flame retardants written in 2013 by the highly regarded center EHHI (Environment and Human Health, Inc.): FLAME RETARDANTS THE CASE FOR POLICY CHANGE

Published on Leave a comment on BPA Free and BPA Plastic Have Similar Effects

Once again, research shows that "BPA-free" plastic does not mean it is safer than BPA plastic. Both BPA and BPS (the usual replacement for BPA) leach estrogenic chemicals into the foods and beverages, which means negative health effects when ingested. Both BPA and BPS mimic the effects of estrogen, as well as the actions of thyroid hormone. Yes, this study was done on zebrafish, but think of them as "the canaries in the mine" - if it affects them, it could affect humans also, especially developing fetuses and young children.

BPA  and BPS can leach into food, particularly under heat, from the lining of cans and from consumer products such as water bottles, baby bottles, food-storage containers, sippy cups, and plastic tableware. BPA can also be found in contact lenses, eyeglass lenses, compact discs, water-supply pipes, some cash register and ATM receipts, as well as in some dental sealants. A good way to minimize exposure to BPA , BPS, and other estrogenic chemicals is to try to avoid food and beverages in plastic containers and cans, but instead try to buy and store food in glass containers, jars, and bottles. From Science Daily:

'BPA-free' plastic accelerates embryonic development, disrupts reproductive system

Companies advertise "BPA-free" as a safer version of plastic products ranging from water bottles to sippy cups to toys. Many manufacturers stopped used Bisphenol A to strengthen plastic after animal studies linked it to early puberty and a rise in breast and prostate cancers.Yet new UCLA research demonstrates that BPS (Bisphenol S), a common replacement for BPA, speeds up embryonic development and disrupts the reproductive system.

Using a zebrafish model, Wayne and her colleagues found that exposure to low levels of BPA and BPS -- equivalent to the traces found in polluted river waters -- altered the animals' physiology at the embryonic stage in as quickly as 25 hours. "Egg hatching time accelerated, leading to the fish equivalent of premature birth," said Wayne, who is also UCLA's associate vice chancellor for research. "The embryos developed much faster than normal in the presence of BPA or BPS."

The UCLA team, which included first author Wenhui Qiu, a visiting graduate student from Shanghai University, chose to conduct the study in zebrafish because their transparent embryos make it possible to "watch" cell growth as it occurs.... In a second finding, the team discovered that the number of endocrine neurons increased up to 40 percent, suggesting that BPA overstimulates the reproductive system.... "We saw many of these same effects with BPS found in BPA-free products. BPS is not harmless."

After uncovering her first finding about BPA in 2008, Wayne immediately discarded all of the plastic food containers in her home and replaced them with glass. She and her family purchase food and drinks packaged in glass whenever possible. "Our findings are frightening and important," emphasized Wayne. "Consider it the aquatic version of the canary in the coal mine."

Finally, the researchers were surprised to find that both BPA and BPS acted partly through an estrogen system and partly through a thyroid hormone system to exert their effects. "Most people think of BPA as mimicking the effects of estrogen. But our work shows that it also mimics the actions of thyroid hormone," said Wayne. "Because of thyroid hormone's important influence on brain development during gestation, our work holds important implications for general embryonic and fetal development, including in humans."

Researchers have proposed that endocrine-disrupting chemicals may be contributing to the U.S.' rise in premature human births and early onset of puberty over the past couple of decades. "Our data support that hypothesis," said Wayne. "If BPA is impacting a wide variety of animal species, then it's likely to be affecting human health. Our study is the latest to help show this with BPA and now with BPS."

Published on Leave a comment on Microbes Partially Restored To C-Section Babies

I posted about this amazing research while it was still ongoing (Jan. 16, 2015), but now a study has been published. The small well-done pilot study looked at the microbiome (microbial communities) and microbial differences between different groups of infants during the first 30 days of life. They found significant differences in the bacteria of C-section infants (not exposed to their mother's vaginal fluid in the birth canal) compared to C-section infants who were swabbed with a gauze pad right after birth with their mother's vaginal fluids. They found that the microbiota (community of microbes) is partially restored in the swabbed C-section infants and more similar to that of vaginally delivered infants (who were exposed to the maternal bacteria naturally in the birth canal). They found that the procedure restored some bacteria, such as Lactobacillus and Bacteroides, which were nearly absent in the skin and anal samples of non-swabbed C-section babies.

In the C-section group, four mothers who were free of infections that might harm the babies, incubated a sterile gauze in their vaginas for one hour before the operation (C-section). Then, within two minutes of birth, the babies were swabbed with the gauze first over their mouths, then their faces, and then the rest of their bodies. These results are important because it is thought that microbiome differences (depending on method of birth) are long-lasting (with higher incidence of some health problems later in life with C-sections), and because the baby's early microbiome helps educate the baby's developing immune system.

Rob Knight (a leading microbiologist and one of the researchers) pointed out that the study "provides the proof-of-concept that microbiome modification early in life is possible." Now we need to see if these microbial differences persist over time and if it makes a health difference. From Science Daily:

Vaginal microbes can be partially restored to c-section babies

In a small pilot study, researchers at University of California, San Diego School of Medicine and Icahn School of Medicine at Mount Sinai determined that a simple swab to transfer vaginal microbes from a mother to her C-section-delivered newborn can alter the baby's microbial makeup (microbiome) in a way that more closely resembles the microbiome of a vaginally delivered baby. 

Babies delivered by C-section differ from babies delivered vaginally in the makeup of the microbes that live in and on their bodies. These early microbiomes help educate the baby's developing immune system. Previous research suggests a link between C-section delivery and increased subsequent risk of obesity, asthma, allergies, atopic disease and other immune deficiencies. Many of these diseases have also been linked to the microbiome, though the role a newborn's microbiome plays in current or long-term health is not yet well-understood....Other research suggests that microbiome differences between vaginal and C-section babies can persist for years."

In the study, the researchers collected samples from 18 infants and their mothers, including seven born vaginally and 11 delivered by scheduled C-section. Of the C-section-delivered babies, four were exposed to their mothers' vaginal fluids at birth as part of this study. To do this, sterile gauze was incubated in the mothers' vaginas for one hour before the C-section. Within two minutes of their birth, the babies delivered by C-section were swabbed with the gauze starting with the mouth, then the face and the rest of the body.

Six times over the first month after birth, the researchers collected a total of 1,519 anal, oral and skin samples from the mothers and infants. Knight's team then used a gene sequencing technique to map the types and relative quantities of bacterial species present at each body site.

Here's what they found: the microbiomes of the four C-section-delivered infants exposed to vaginal fluids more closely resembled those of vaginally delivered infants than unexposed C-section-delivered infants, though the difference was more distinct in their oral and skin samples than in their anal samples. This partial microbial restoration could be due to the fact that the infants received only one surface application of maternal vaginal fluids, Knight said.

Yet the oral and skin microbiome differences between C-section-delivered infants who received the microbial transfer and those who did not was still noticeable one month after birth. The results were not due to diet differences, as all of the infants received breast milk either exclusively or supplemented with formula during the first month of life. In addition, consistent with previous studies, the babies' microbiome profiles did not correlate with the amount of breast milk they received.

"The present work is a pilot study -- we need substantially more children and a longer follow-up period to connect the procedure to health effects," said Knight...."This study points the way to how we would do that, and provides the proof-of-concept that microbiome modification early in life is possible. In fact, we already have more than 10,000 additional samples collected as part of this study that still await analysis."

Published on Leave a comment on Oral Contraceptives, Pregnancy, and Birth Defects

This is an issue that a lot of women I've known over the years have wondered about: if a woman gets pregnant while on birth control pills (oral contraceptives) - and many women do - does it mean higher rates of birth defects? This study says NO to higher rates of major birth defects which is very reassuring, but it doesn't answer the issue of more subtle effects (e.g., behavioral effects) from the hormones in the contraceptives. From Medical Xpress:

Oral contraceptive use not associated with increased birth defects risk

Oral contraceptives taken just before or during pregnancy do not increase the risk of birth defects, according to a new study by researchers from Harvard T.H. Chan School of Public Health and the Statens Serum Institut in Denmark. They found that the prevalence of major birth defects was consistent (about 25 per 1,000 live births) across all pregnant women in the study population regardless of contraceptive use.

Even though oral contraceptives are more than 99% effective with perfect use, almost 10% of women become pregnant within their first year of use. Many more women will stop using oral contraceptives when planning a pregnancy and conceive within a few months. Little is known about the potential health effects to children from in utero exposure to the hormones in oral contraceptives.

....Charlton and colleagues were able to tap into a wealth of data collected from multiple Danish health registries between 1997 and 2011 and linked by the unique personal identification number assigned to all Denmark residents. The researchers looked at 880,694 live-born infants, and the health of these children at one-year follow-up. Oral contraceptive use was estimated based on the date of the mother's most recently filled prescription.  Among the women in the study population, a fifth had never used oral contraceptives before becoming pregnant, and more than two-thirds had stopped using oral contraceptives at least three months before becoming pregnant. Eight percent had discontinued use within three months of becoming pregnant, and 1%, or well over 10,000 women, had used oral contraceptives after becoming pregnant.

The prevalence of birth defects was consistent across each category of oral contraceptive use, and remained so when the researchers added in pregnancies that ended as stillbirths or induced abortions.

Published on Leave a comment on Phthalates, Sperm, and Miscarriages

More and more negative news about phthalates: men with greater exposure to DEHP (a phthalate) have lower sperm motility (how the sperm move or their ability to swim), and pregnant women with higher levels of phthalates have a higher rate of pregnancy loss (miscarriages - mainly between 5 and 13 weeks of pregnancy). Phthalates are found in many plastics, are thought to be endocrine disruptors, and can be measured in urine. From Medical Xpress: Lower sperm motility in men exposed to common chemical

Men with higher exposure to the substance DEHP, a so-called phthalate, have lower sperm motility and may therefore experience more difficulties conceiving children, according to a Lund University study. Phthalates is an umbrella term for a group of substances based on phthalic acid, some of which are suspected to be endocrine disruptors. Many phthalates are found in soft plastics in our daily surroundings.... Since phthalate molecules leak out of plastics, we are exposed to it daily and absorb the chemicals through food, drink, skin contact and inhalation. 

"We have studied metabolite levels of the phthalate DEHP (diethylhexyl phthalate) in urine as an indicator of exposure, as well as the semen quality of 300 men between the ages of 18 and 20. The results show that the higher metabolite levels the men had, the lower their sperm motility was", says Jonatan Axelsson, researcher at the Department of Laboratory Medicine, Lund University. For the one quarter of the men with the lowest levels of exposure, 57 per cent of the sperm cells were moving forward, compared to 46 per cent for the quarter of the men with the highest levels of exposure.

As previous research has reported that there is a linear connection also between sperm motility and chances of becoming pregnant, the findings could indicate that the more exposed one is to DEHP, the smaller the chances are of having children.

From Medical Xpress:  Exposure to phthalates could be linked to pregnancy loss

A new study of more than 300 women suggests that exposure to certain phthalates—substances commonly used in food packaging, personal-care and other everyday products—could be associated with miscarriage, mostly between 5 and 13 weeks of pregnancy. 

Out of concern over the potential health effects of phthalates, the U.S. has banned six of these substances from use in certain products made for young children. But many are still included as ingredients in paints, medical tubes, vinyl flooring, soaps, shampoos and other items. Research on phthalates has shown that long-term exposure to low levels of the some of these compounds harms lab animals' health and can increase their risk for pregnancy loss. Additionally, at least one study found that female factory workers exposed to high levels of phthalates through their work were at a higher risk for miscarriage.

The researchers tested urine samples from 132 women who had miscarriages and 172 healthy pregnant women in China. They found pregnancy loss was associated with higher levels of urinary phthalate metabolites from diethyl phthalate (DEP), di-isobutyl phthalate (DiBP) and di-n-butyl phthalate (DnBP). Although this doesn't prove that phthalates cause pregnancy loss, the study suggests an association exists that the researchers say should be studied further.

Published on Leave a comment on Taking Antidepressants During Pregnancy and Autism

A large study found that using antidepressants during the second or third trimester of pregnancy increases the risk that the child will have autism by 87%,  especially if the mother takes selective serotonin reuptake inhibitors (SSRIs). A drawback was that the study looked at associations rather than actual cause (which would have meant randomly assigning women to either treatment or no treatment - which is unethical). From Medical Xpress:

Taking antidepressants during pregnancy increases risk of autism by 87 percent

Using antidepressants during pregnancy greatly increases the risk of autism, Professor Anick Bérard of the University of Montreal and its affiliated CHU Sainte-Justine children's hospital revealed today. Prof. Bérard, an internationally renowned expert in the fields of pharmaceutical safety during pregnancy, came to her conclusions after reviewing data covering 145,456 pregnancies.

"The variety of causes of autism remain unclear, but studies have shown that both genetics and environment can play a role," she explained. "Our study has established that taking antidepressants during the second or third trimester of pregnancy almost doubles the risk that the child will be diagnosed with autism by age 7, especially if the mother takes selective serotonin reuptake inhibitors, often known by its acronym SSRIs." Her findings were published today in JAMA Pediatrics.

Bérard and her colleagues worked with data from the Quebec Pregnancy Cohort and studied 145,456 children between the time of their conception up to age ten. In addition to information about the mother's use of antidepressants and the child's eventual diagnosis of autism, the data included a wealth of details that enabled the team to tease out the specific impact of the antidepressant drugs. 

"We defined exposure to antidepressants as the mother having had one or more prescription for antidepressants filled during the second or third trimester of the pregnancy. This period was chosen as the infant's critical brain development occurs during this time," Prof. Bérard said. "Amongst all the children in the study, we then identified which children had been diagnosed with a form of autism by looking at hospital records indicating diagnosed childhood autism, atypical autism, Asperger's syndrome, or a pervasive developmental disorder. Finally, we looked for a statistical association between the two groups, and found a very significant one: an 87% increased risk." 

The findings are hugely important as six to ten percent of pregnant women are currently being treated for depression with antidepressants. In the current study, 1,054 children were diagnosed with autism (0.72% of the children in the study), on average at 4.5 years of age. Moreover, the prevalence of autism amongst children has increased from 4 in 10,000 children in 1966 to 100 in 10,000 today. While that increase can be attributed to both better detection and widening criteria for diagnosis, researchers believe that environmental factors are also playing a part.

"It is biologically plausible that anti-depressants are causing autism if used at the time of brain development in the womb, as serotonin is involved in numerous pre- and postnatal developmental processes, including cell division, the migration of neuros, cell differentiation and synaptogenesis - the creation of links between brain cells," Prof. Bérard explained. "Some classes of anti-depressants work by inhibiting serotonin (SSRIs and some other antidepressant classes), which will have a negative impact on the ability of the brain to fully develop and adapt in-utero".

Published on Leave a comment on Endocrine Disrupting Chemicals and Male Infertility

Recent research looked at environmental causes of male infertility, specifically endocrine-disrupting chemicals. Poor semen quality contributes to increases in infertility and the use of assisted reproductive technology.The researchers also discuss the higher incidence of testicular cancer worldwide, lower levels of testosterone in men, and poor semen quality among men aged 20 to 25 (with the average man having up to 90% abnormal sperm). From Science Daily:

Endocrine-disrupting chemicals may be threatening fertility in industrialized countries

The birth rate is declining in all industrialised countries, and socioeconomic factors and women's age are not solely to blame. Male reproductive health and environmental factors are also significant, as concluded in a new scientific review article. ...Behind the article are fertility researchers from Denmark, the US and Finland. The researchers studied a number of factors related to fertility, and one of the main conclusions of their study was that poor semen quality contributed to increases in infertility and the use of assisted reproductive technology.

The study also revealed higher incidence of testicular cancer worldwide, with the greatest frequency among Caucasian populations. Moreover, the researchers also observed lower levels of testosterone in average men. "I was surprised that we found such poor semen quality among young men aged 20 to 25. The average man had up to 90% of abnormal sperm. Normally, there would be so many sperms that a few abnormal ones would not affect fertility. However, it appears that we are at a tipping point in industrialised countries where poor semen quality is so widespread that we must suspect that it results in low pregnancy rates," said first author of the article, Professor Niels E. Skakkebaek from the Department of Growth and Reproduction (EDMaRC) at Rigshospitalet and the University of Copenhagen.

"The article also demonstrates the impact of the increasing number of male reproductive problems on low birth rates. There is no doubt that environmental factors are playing a role. These are the correlations we are researching at the new research centre EDMaRC at Rigshospitalet," added Professor Anders Juul, who is the last author of the article.

Many of the male reproductive problems could be due to damage to the testes during embryonic development. While the reproductive problems could arise from genetic changes, "recent evidence suggests that most often they are related to environmental exposures of the fetal testes," the researcher team wrote."Since the disorders in male genitals have increased over a relatively short period of time, genetics alone cannot explain this development. There is no doubt that environmental factors are playing a role and that endocrine-disrupting chemicals, which have the same effect on animals, are under great suspicion. The exposure that young people are subjected to today can determine not only their own, but also their children's, ability to procreate," explained Professor Skakkebaek.

Published on Leave a comment on More Negative News About Hormone Disrupting Chemicals

More and more studies are finding negative health effects from hormone disrupting chemicals (which we are exposed to every single day, and subsequently which are in all of us), such as parabens, phthalates, Bisphenol-A (BPA), and chemical substitutes for BPA such as Bisphenol-S (BPS) and BPF. The following are a few recent studies and one article from my files. Also check out the other endocrine disrupting chemical studies I've posted (SEARCH: 'endocrine disruptors', and 'phthalates').

Bottom line: Read labels and try to minimize plastics in personal care products (e.g., lotion) and your food if possible (e.g., choose glass, stainless steel, wax paper, aluminum foil). This is especially important during pregnancy.  Even BPA alternatives (labeled BPA-free) should be viewed as the same as BPA - as endocrine disruptors. In other words, currently there are no good BPA substitutes. Don't microwave food in a plastic dish or container, or covered with plastic wrap. Eat fresh foods rather than packaged, processed foods. From Newsweek:

BPA Is Fine, If You Ignore Most Studies About It

Bisphenol-A (BPA) is either a harmless chemical that’s great for making plastic or one of modern society’s more dangerous problems. Depends whom you ask. BPA is in many types of plastics and the epoxy resins that line most aluminum cans, as well as thermal papers like receipts. It is an endocrine disruptor that mimics estrogen, a hormone especially important in sexual development, and the fact that it’s all over the place worries many people. Newsweek spoke with about 20 scientists, leaders in the field of BPA research, and the majority say it is likely (though not certain) that the chemical plays a role in a litany of health concerns: obesity, diabetes, problems with fertility and reproductive organs, susceptibility to various cancers and cognitive/behavioral deficits like ADHD.  ...continue reading "More Negative News About Hormone Disrupting Chemicals"