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Author: Sima

Published on Leave a comment on Perhaps The Type Of Iron Supplement Matters

Does the type of iron in supplements and additives matter for your health? OK, this was a preliminary study and done in a lab using human cells, which means much more research needs to be done, but... It may be that different forms of iron in supplements and additives have slightly different effects in the human body, specifically the intestines. Ferrous sulphate so far looks good (had no effect on the cancer cells studied), while 2 other forms of iron - ferric citrate and ferric EDTA - may actually promote the formation of colon cancer. That is, they may be considered carcinogenic.

Ferric EDTA and ferric citrate have been observed to promote colon cancer in studies using mice. Bottom line: When buying supplements and foods, check labels to make sure the iron is in the form of ferrous sulphate, and not ferric citrate or ferric EDTA. From Science Daily:

Certain iron supplements may influence the development of colon cancer ...continue reading "Perhaps The Type Of Iron Supplement Matters"

Published on Leave a comment on Fruits, Vegetables, and Pesticide Residues

Wondering which fruits and vegetables have the most pesticide residues? The annual Dirty Dozen List of produce with the most pesticide residues has once again been published by the Environmental Working Group (EWG). They suggest that these fruits and vegetables are good candidates for buying organic.

Why organic? Because while almost 70 % of the produce sampled by the Federal Government had pesticide residues, some have more than others. For example: about one-third of the strawberries sampled contained 10 or more pesticides. Yikes! The following article also discusses some recent reproductive research and  pesticides on food, as well as EWG's "Clean Fifteen" list of fruits and vegetables with the least pesticide residues. (See more PESTICIDE posts.) From Environmental Health News:

Report calls out worst produce for pesticides—strawberries, spinach top list

Just when you thought it couldn't get any harder to eat healthy. Turns out those nutrient packed foods we're all told to eat—such as strawberries and spinach— are also consistently tainted with potentially harmful pesticides. Both foods top the "Dirty Dozen" list released today by the Environmental Working Group (EWG), which analyzed federal data on pesticides in produce.

EWG, which examined tests done over the past few years by the U.S. Department of Agriculture, reports almost 70 percent of the produce sampled by the feds had pesticide residues. Some were worse than others: "More than 98 percent of samples of strawberries, spinach, peaches, nectarines, cherries and apples tested positive for residue of at least one pesticide," according to the report.  ...continue reading "Fruits, Vegetables, and Pesticide Residues"

Published on Leave a comment on Even Low Level Lead Exposure Is Linked to Later Health Problems

New research published in The Lancet estimates that lead exposure results in about 400,000 deaths every year in the USA - which includes about 250,000 deaths from cardiovascular disease. The study looked at "historical exposure" to lead, which means they looked at a person's lead exposure years ago (which could have been from many sources, such as breathing lead contaminated dust, drinking water from leaded pipes, from lead paint, leaded gas, or eating from cans that have been soldered with lead). What was noteworthy in this study following over 14,000 adults was that there were increased death rates even from low lead blood levels (concentrations of lead in blood lower than 5 μg/dL).

Lead exposure has been declining since the 1970s after lead was eliminated (banned) from paint and gasoline, but this study looked at adults born in the years when lead exposure was higher during childhood and adulthood. Baseline data (blood lead levels) was collected between 1988 and 1994 and then individuals were followed for the next 2 decades. The researchers found that there was a dose response curve - the higher the blood lead level, the higher the death rate from any cause (all-cause mortality), from cardiovascular disease, and from ischaemic heart disease in the next two decades.

Lead is a naturally occurring heavy metal, but it's also a poisonous substance for humans, and accumulates in teeth and bones. Lead can pass through the blood-brain barrier in children and fetuses and kill brain cells (and cause neurological damage). Lead can enter blood vessels and harm the endothelial cells that line the blood vessels. This process hardens arteries and causes plaque to form in blood vessels, increasing blood pressure, and the risk of heart disease and stroke. Lead can damage the kidneys, which play an important role in regulating blood pressure, and so increase a person’s risk of heart disease and stroke.

The Centers for Disease Control and Prevention (CDC) have stated that there are no safe blood levels of lead for children (zero is best), and the researchers of this study believe the same is true for adults. From Science Daily:

Historical lead exposure may be linked to 256,000 premature deaths from cardiovascular disease in adults in United States each year

New estimates suggest that 256,000 premature deaths from cardiovascular disease -- including 185,000 deaths from ischemic heart disease -- in the USA may be linked to historical lead exposure in middle-aged and older adults (people currently aged 44 years or over), according to an observational study following 14,300 people for almost 20 years, published in The Lancet Public Health journal.  ...continue reading "Even Low Level Lead Exposure Is Linked to Later Health Problems"

Published on Leave a comment on Negative Major Life Events and the Middle-Aged Male Brain

This recent study adds to the body of knowledge of what negative major life events (resulting in lots of stress, anxiety, worry) does to a middle-aged person's health. Negative life events could be an interpersonal conflict (e.g. divorce), a death in the family, financial hardship, and serious medical emergencies. Using MRIs, the researchers found that each fateful life event (FLE), especially those that involve interpersonal relationships, accelerates brain aging about .37 years (about a third of a year). And the more negative life events, the bigger the effect. From Science Daily:

Negative fateful life events and the brains of middle-aged men

Conflict, a death in the family, financial hardship and serious medical crises are all associated with accelerated physical aging. In a new study, researchers at the University of California San Diego School of Medicine found that such negative fateful life events -- or FLEs -- appear to also specifically accelerate aging in the brain. 

Writing in the journal Neurobiology of Aging, a research team, led by senior author William S. Kremen, PhD, professor of psychiatry and co-director of the Center for Behavior Genetics of Aging at UC San Diego School of Medicine, found that major adverse events in life, such as divorce, separation, miscarriage or death of a family member or friend, can measurably accelerate aging in the brains of older men, even when controlling for such factors as cardiovascular risk, alcohol consumption, ethnicity and socioeconomic status, which are all associated with aging risk. 

Specifically, they found that on average, one FLE was associated with an increase in predicted brain age difference (PBAD) of 0.37 years. In other words, a single adverse event caused the brain to appear physiologically older by approximately one-third of a year than the person's chronological age, based upon magnetic resonance imaging (MRI). 

The researchers studied 359 men, ages 57 to 66 years old, participating in the Vietnam Era Twin Study of Aging (VETSA). Researchers asked participants to tally a list of life-changing events over the past two years .... All participants underwent MRI exams and further physical and psychological assessments within one month of completing the most recent self-reports. The MRIs assessed physiological aspects of the brain, such as volume and cortical thickness -- a measure of the cerebral cortex or outer layer of the brain linked to consciousness, memory, attention, thought and other key elements of cognition.

Hatton said exposure to chronic stress has long been associated with biological weathering and premature aging, linked, for example, to oxidative and mitochondrial damage in cells, impaired immune system response and genomic changes. The study's authors said their findings provide a possible link between molecular aging and brain structure changes in response to major stressful life events. They do note that the study was a snapshot of a narrow demographic: older, predominantly white, males. It is not known whether females or other ethnicities would show similar findings.

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Published on 2 Comments on Losing Your Wealth In Late Middle-Age and Increased Risk of Death

Of course! The results of this study made perfect sense to me - that losing your wealth or savings in late middle-age is such a mental shock ("negative wealth shock") that it increases the risk of death for any reason ("all cause mortality") tremendously over the next 20 years. About 50% increased risk of death. For example, if you have to live off your savings after you get laid off or can't work due to illness, and perhaps even lose your house to foreclosure, is STRESSFUL beyond belief. Almost incomprehensible to anyone who has not personally gone through it.

On top of that, a person may then not be able to afford to go to the doctor, even if there is a problem, once they're financially stressed. And of course they may never financially recover because the "negative wealth shock" happened at an older age (the people were 51 to 61 at the start of the study).

Other research conducted at time of the Great Recession showed significant associations between negative wealth shocks and short-term health changes - including increased risk of depression, anxiety, suicide, impaired cardiovascular function, and substance abuse. And now we know that long-term there is an increased risk of death. From Science Daily:

Losing your nest egg can kill you

A sudden loss of net worth in middle or older age is associated with a significantly higher risk of death, reports a new Northwestern Medicine and University of Michigan study. When people lose 75 percent or more of their total wealth during a two-year period, they are 50 percent more likely to die in the next 20 years, the study found.  ...continue reading "Losing Your Wealth In Late Middle-Age and Increased Risk of Death"

Published on Leave a comment on Ultra-Processed Foods and Alzheimer’s?

The last post dealt with the link between highly processed food and increased risk of cancer. Now an interesting article written by Dr. Lisa Mosconi (Associate Director of the Alzheimer’s Prevention Clinic at Weill Cornell Medical College/New York -Presbyterian Hospital) refers to that study when discussing research about lifestyles (and especially diet) and later Alzheimer's disease.

It'll be interesting to see how this research plays out - is her approach stressing diet (and avoiding ultra-processed food and trans fats) and lifestyle correct or not? Much of what she says definitely makes sense and is supported by research, such as the negative health effects of chronic inflammation, and how eating actual, real foods has beneficial health effects. On the other hand, vitamin, mineral, and fish oil supplements generally don't show those health benefits (as she discusses here).

Currently there are a number of theories about causes of Alzheimer's disease (including the role of microbes), as well as a number of drug treatments that so far have gone nowhere. If Dr. Mosconi's research interests you, then read the interview she did in 2017. [In the interview she talks about the importance of exercise, intellectual stimulation, social networks, and the benefits of eating real foods rather than supplements. She recommends: drink water, eat fish, eat vegetables and fruit, eat glucose rich foods, and don't eat highly processed and fast foods.]  From Quartz:

The road to Alzheimer’s disease is lined with processed foods

Dementia haunts the United States. There’s no one without a personal story about how dementia has touched someone they care for. But beyond personal stories, the broader narrative is staggering: By 2050, we are on track to have almost 15 million Alzheimer’s patients in the US alone. ... It’s an epidemic that’s already underway—but we don’t recognize it as such. The popular conception of Alzheimer’s is as an inevitable outcome of aging, bad genes, or both.  ...continue reading "Ultra-Processed Foods and Alzheimer’s?"

Published on Leave a comment on Ultra-Processed Food and Risk of Cancer

A recent study published in BMJ (British Medical Journal) found a link between high consumption of ultra-processed food and higher rates overall of cancer, but also a higher risk of breast cancer. Specifically, a 10% increase in the proportion of ultra-processed foods in the diet was associated with a greater than 10% increase of overall cancer and 11% increase of breast cancer during the 6+ years of the study.

Alarmingly (because of the health implications), several surveys (in Europe, the US, Canada, New Zealand, and Brazil) have suggested that ultra-processed food products are now between 25 to 50% of calories eaten every day.

Ultra-processed food is food that is highly processed. It is food that is mass produced and packaged, as well as foods that have manufactured substances in them - such as hydrogenated oils (also contains trans fats), protein isolates, additives, preservatives, artificial or natural flavors, colors, nitrites (in processed meat), titanium dioxide (nanoparticles), etc.

The food packaging can leach chemicals such as pthalates (endocrine disruptors). The list goes on and on and on. All of these things in ultra-processed foods may be involved in causing health problems, including cancer.

They are typically also poorer nutritionally and higher in salt than unprocessed or minimally processed foods. These ultra-processed foods that are so popular are all around us - in fast food, in mass produced desserts and breads, packaged snacks, soups, cold cuts, margarine, frozen or shelf stable ready to eat meals, instant foods, sodas and drinks, etc.

On the other hand, unprocessed or minimally processed foods are fresh, dried, ground, chilled, frozen, pasteurised, or fermented foods such as fruits, vegetables, legumes (beans), rice, pasta, eggs, meat, fish, or milk. There are also “processed culinary ingredients”  which are salt, vegetable oils, butter, sugar, and other substances extracted from foods and used in kitchens to transform unprocessed or minimally processed foods into "culinary preparations" (meals).

The study did NOT find any association with unprocessed, minimally processed, or processed culinary ingredients with cancer. Only with the ultra-processed food. Instead, the study found that higher consumption of “minimally/unprocessed foods” (and lower ultra-processed food) was associated with lower risks of overall cancer and breast cancer.

So an apple is unprocessed, and plain apple sauce made with just apples is minimally processed, while a packaged apple dessert with additives added is ultra-processed. Think of it as "transformed food". Also keep in mind that your beneficial gut microbes like unprocessed or minimally processed food - especially those high in fiber. You know - a diet rich in fruits, vegetables, whole grains, seeds, nuts, legumes (beans).  ...continue reading "Ultra-Processed Food and Risk of Cancer"

Published on Leave a comment on DASH Diet Linked To Lower Rate of Depression

A number of recent studies and articles have discussed the effectiveness of diet in treating or preventing depression with the main conclusion that yes, it helps. Now an observational study (that will be presented in April) found that elderly people following the DASH diet most closely were 11% less likely to become depressed over time than those that did not.

Researchers studying 964 elderly participants over six and a half years found that those who followed the DASH diet, which emphasizes whole grains, fruits, and vegetables, had lower rates of depression, while those who ate a traditional Western diet were more prone to depression. The DASH (Dietary Approaches to Stop Hypertension) diet also emphasizes low sodium (salt) to lower blood pressure, as well as foods rich in nutrients (such as potassium, calcium, and magnesium) that are thought to lower blood pressure.

The study's lead author L. J. Cherian (at Rush Medical Center in Chicago) said that "we need to view food as medicine”. Yes. Eating more fruits and vegetables, whole grains, legumes, seeds, nuts have many health benefits (such as cardiovascular benefits, improving the gut microbes) -  a win-win. From Science Daily:

Diet shown to reduce stroke risk may also reduce risk of depression

People who eat vegetables, fruit and whole grains may have lower rates of depression over time, according to a preliminary study that will be presented at the American Academy of Neurology's 70th Annual Meeting in Los Angeles, April 21 to 27, 2018. The study found that people whose diets adhered more closely to the Dietary Approaches to Stop Hypertension (DASH) diet were less likely to develop depression than people who did not closely follow the diet. In addition to fruit and vegetables, the DASH diet recommends fat-free or low-fat dairy products and limits foods that are high in saturated fats and sugar. Studies have shown health benefits such as lowering high blood pressure and bad cholesterol (LDL), along with lowering body weight.  ...continue reading "DASH Diet Linked To Lower Rate of Depression"

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Published on 3 Comments on Some Antibiotics Can Have Crippling Side Effects

Study after study, and such influential researchers as Dr. Martin Blaser (at New York University) have warned about antibiotics having a negative effect on the human microbiome - that they kill off gut microbes. And all conclude that therefore antibiotics should be used carefully - only when needed. But there are other reasons to be cautious about antibiotics as a recent article warned. Some people who take the class of antibiotics called fluoroquinolones develop a syndrome called fluoroquinolone-associated disability (FQAD) which causes crippling side-effects, including irreversible nerve damage. People who have fallen ill after taking fluoroquinolones call it being "floxed".

The FDA currently has "black box" warnings about fluoroquinolones - that they can cause tendon rupture or a risk of irreversible nerve damage in those taking the antibiotics. Black box warnings are placed inside a black box on drug labels and call attention to serious or life-threatening risks. Millions have taken these drugs, but some (the FDA considers it a rare event) develop the serious side-effects.

Many people (myself included) have taken fluoroquinolones, such as Levaquin, over the years for sinusitis treatment. Some have taken them multiple times. Most have not reported side-effects (including myself), but those who developed serious side-effects (floxed) are desperate for sinusitis treatments that don't involve taking antibiotics. Which is where alternative treatments using probiotics such as Lactobacillus sakei come in (yes, it works for sinusitis!). Excerpts from Nature (the international journal of science):

When Antibiotics Turn Toxic

In 2014, Miriam van Staveren went on holiday to the Canary Islands and caught an infection. Her ear and sinuses throbbed, so she went to see the resort doctor, who prescribed a six-day course of the popular antibiotic levofloxacin. Three weeks later, after she had returned home to Amsterdam, her Achilles tendons started to hurt, then her knees and shoulders. She developed shooting pains in her legs and feet, as well as fatigue and depression. “I got sicker and sicker,” she says. “I was in pain all day.” Previously an active tennis player and hiker, the 61-year-old physician could barely walk, and had to climb the stairs on all fours. Since then, she has seen a variety of medical specialists. Some dismissed her symptoms as psychosomatic. Others suggested diagnoses of fibromyalgia or chronic fatigue syndrome. Van Staveren is in no doubt, however. She’s convinced that the antibiotic poisoned her.

She’s not alone. Levofloxacin is one of a class of drugs called fluoroquinolones, some of the world’s most commonly prescribed antibiotics. In the United States in 2015, doctors doled out 32 million prescriptions for the drugs, making them the country’s fourth-most popular class of antibiotic. But for a small percentage of people, fluoroquinolones have developed a bad reputation. On websites and Facebook groups with names such as Floxie Hope and My Quin Story,thousands of people who have fallen ill after fluoroquinolone treatment gather to share experiences. Many of them describe a devastating and progressive condition, encompassing symptoms ranging from psychiatric and sensory disturbances to problems with muscles, tendons and nerves that continue after people have stopped taking the drugs. They call it being ‘floxed’.  ...continue reading "Some Antibiotics Can Have Crippling Side Effects"

Published on Leave a comment on Popular Weedkiller Found In Pregnant Women

A recent study of pregnant women found new health problems with the pesticide glyphosate, which is the active ingredient in the weedkiller Roundup (made by Monsanto).

The researchers found that women  with higher levels of glyphosate are more likely to have shorter pregnancies. Another major finding was that almost all the pregnant women (93%) in this study had detectable levels of glyphosate in their urine. I posted about this study earlier, but now it has been published in the journal Environmental Health.

All the pregnant women were living in central Indiana (in the cornbelt) in a mix of areas (suburban, urban, and rural), and whether they had well or public drinking water. In case you don't know, it is not good for a baby to be born early, and there can be lifelong health consequences - so every extra week (till full term) is good during pregnancy.

The researchers found higher levels of glyphosate in women living in rural areas (farm areas) and those drinking greater than 24 ounces a day of caffeinated beverages. The researchers thought that diet (food) and inhalation of contaminated dust were the major ways that the glyphosate got into the pregnant women.

Glyphosate is the most heavily used herbicide (a type of pesticide) in the world. Nearly 300 million pounds were applied in the U.S. in 2015, with much of the application in the Midwest. Scroll down to see a USGS map of glyphosate (Roundup) use in 2015 in the US. You can see that incredibly huge amounts of glyphosate are used in the midwest on farmland - greater than 88.6 pounds per square mile! (it's the dark brown areas on the map). Top crops it's used on are corn, soybeans, and canola, especially genetically modified Roundup Ready crops.

It is also used as a dessicant right before harvest ("preharvest") on many crops. This is why crops have glyphosate residues on them, and why so many streams and lakes are contaminated (due to agricultural runoff). About 90% of corn and soybean crops grown in the United States are Roundup Ready, and then these grains are used in most processed foods. Note: glyphosate (Roundup) can not be used on organic crops.

The herbicide has been linked to a number of health problems, including cancer, birth defects, endocrine disruption, and reproductive problems. (Posts on glyphosate.)  There are currently hundreds of lawsuits from farmers and others claiming that Roundup gave them cancer.

...continue reading "Popular Weedkiller Found In Pregnant Women"