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Published on Leave a comment on Periodontal Disease Link to Alzheimer’s Disease?

In the last few years a number of researchers have suggested that microbes may be triggering or somehow causing Alzheimer's disease. Various microbes have been suggested, and research is finding links with herpes viruses, fungi, other microbes, and gum disease (periodontal disease) microbes. Now another study proposes that the common bacteria Porphyromonas gingivalis - which causes chronic periodontal disease, is linked to the development of Alzheimer's disease.

Researchers have suggested that during an initial infection, the "infectious agent" (viruses, etc.) reaches the central nervous system and brain, then stays there in latent form (inactive) for years. And then when the immune system declines with age (which is a normal part of aging) - the microbes (virus, fungi, etc.) become reactivated and cause inflammation and the chain of events leading to Alzheimer's disease.

Note that in the recent study implicating P. gingivalis - the Cortexyme, Inc. company is doing the research and they, of course, are developing a product - so beware of bias. Also, the research done so far is in the earliest stages. But...it is exciting to see if further research (from them and from others) supports some sort of microbe, or several types of microbes, behind the development of Alzheimer's disease. Will we find that there is an "infectious cause" of Alzheimer's disease ("infection-induced neuroinflammation")? Because this means that there is a way to prevent or treat Alzheimer's disease - some sort of antimicrobial, antibiotic, antiviral, or antifungal. Stay tuned for further research.... From Medical Xpress:

Bacterial pathogen Porphyromonas gingivalis may contribute to Alzheimer's disease: Study

Cortexyme, Inc., a privately held, clinical-stage pharmaceutical company developing therapeutics to alter the course of Alzheimer's disease (AD) and other degenerative disorders, today announced publication of a foundational paper supporting its approach in Science Advances. In the paper, an international team of researchers led by Cortexyme co-founders Stephen Dominy, M.D. and Casey Lynch detail the role of a common bacterium, Porphyromonas gingivalis (Pg), in driving Alzheimer's disease pathology, and demonstrate the potential for small molecule inhibitors to block the pathogen.  ...continue reading "Periodontal Disease Link to Alzheimer’s Disease?"

Published on Leave a comment on Eating Lots of Fiber Has Health Benefits

How many times have you heard to eat lots of fruits, vegetables, whole grains, nuts, legumes (beans), and seeds? Study after study finds that eating a diet rich in these foods is linked to all sorts of health benefits. A big reason is that they have lots of fiber - which feeds beneficial microbes in our gut. A recently published review of studies in the prestigious journal Lancet examined studies done over the past 40 years and found numerous health benefits.

The researchers found that people consuming high levels of dietary fiber and whole grains have a lower risk of death from heart disease (cardiovascular mortality) and death from any cause. They also have a lower incidence of heart disease, stroke, type 2 diabetes, and colorectal cancer (as compared to those eating less fiber). There was a dose-response effect - in other words, the more fiber eaten daily, the lower the incidence of these diseases and deaths. They also found that a high fiber diet is also linked to lower cholesterol levels, lower weight, and lower blood pressure.

This study viewed 25 to 29 grams per day as a high fiber diet, but said the findings suggest that higher levels of fiber would be even more protective. Which means put down that delicious white bread and sugary cereal and start eating whole grain foods! Nowadays the average person eats less than 20 grams of fiber per day, but guidelines say to eat at least 30 grams per day. The researchers pointed out that getting fiber from real food is best.

From Science Daily: High intake of dietary fiber and whole grains associated with reduced risk of non-communicable diseases

People who eat higher levels of dietary fiber and whole grains have lower rates of non-communicable diseases compared with people who eat lesser amounts, while links for low glycaemic load and low glycaemic index diets are less clear. Observational studies and clinical trials conducted over nearly 40 years reveal the health benefits of eating at least 25g to 29g or more of dietary fiber a day, according to a series of systematic reviews and meta-analyses published in The Lancet.  ...continue reading "Eating Lots of Fiber Has Health Benefits"

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Published on 5 Comments on What Else Can Lactobacillus Sakei Treat?

What can the amazing beneficial bacteria Lactobacilus sakei treat? We know it can treat sinusitis (sinus infections) - based on the original Abreu et al (2012) research, personal experiences, and feedback from hundreds of people since I started this site in 2013. Can it treat bronchitis? Earaches? How about skin infections?

L. sakei dominates over and inhibits growth of pathogenic bacteria, including Staphylococcus aureus. Instead of using antibiotics - what else could L. sakei be used for?

I've been hearing interesting stories from people - a number of people have found that it (kimchi, sauerkraut with garlic, or a L. sakei product such as Lanto Sinus) works to treat coughs (bronchitis), or prevents upper respiratory infections from developing into serious sinus infections, gets rid of fungal balls in the sinuses, treats earaches, and even treats small skin infections. People have been using the various products in creative ways - all self-experimentation!

The experiences of some people contacting me, as well as family members (including myself) - is that it treated bronchitis and coughs for which they would have taken antibiotics in the past - by swishing L. sakei powder (such as Lanto Sinus) in the mouth (but not in the nose).

For example, one person reported that she occasionally gets bronchitis, but never sinusitis - and she successfully used Lanto Sinus to treat the bronchitis by swishing it in the mouth. The first two days she used it 2 x per day, and after that once per day until she felt better, but not totally well - and when she stopped the bronchitis (cough, phlegm) came back. So she used the L. sakei again until she felt totally healthy - and this time the cough stayed away. Since I personally know this person (we take walks together) I was able to observe her progress - cough & phlegm, then improvement, then backwards slide, and then total health when she used the product again. Hmmm... Definitely wasn't an imaginary effect or wishful thinking (placebo effect).

One person dabbed kimchi juice in the ear for an earache and thought it helped (see Sinusitis Success Stories). Others have dabbed Lanto Sinus mixed with water into the ear canal (but not too deep) and thought it helped.

For skin infections some individuals mixed L. sakei with a little water and applied to infection - this has been reported for both frozen Bactoferm F-RM-52 and refrigerated Lanto Sinus.

Not wanting to dab kimchi juice in the nostrils (the usual way to use kimchi for sinusitis), some gargled with kimchi juice and also swished it in the mouth and then didn't eat or drink for a while - but I don't know how the results compare to the usual kimchi method.

But at any rate, the reports from people of various ways to use a L. sakei product are interesting. Just remember - this is all self-experimentation - which means results can be positive, negative, or no effect. And please be cautious!

For ways people use the various Lactobacillus sakei products to treat sinus infections (both chronic sinusitis and acute sinusitis) see the Sinusitis Treatment Summary page. The Best Probiotic For Sinus Infections gives an in-depth look at the different L. sakei products and results.

[Updated January 15, 2020.]

Published on Leave a comment on Food Ingredients Banned in Europe But Not USA

Did you know that some other countries have stricter laws on food additives, drugs, and pesticides than the US? This is especially true with the European countries. It is especially aggravating to read that manufacturers sell foods with one set of ingredients in the US and a better set of ingredients in Europe. (Could it be because the FDA has such nice cozy relationships with Big Ag and lobbyists representing big chemical companies?) So... what can the ordinary person do? Read labels carefully. And try to buy as much organic food as possible, or buy from local farmers where you can find out how they are growing crops or raising animals.

Avoid the following if possible for the next 2 years until companies can no longer have them as ingredients: benzophenone, ethyl acrylate, eugenyl methy ether (methyl eugenol), myrcene, pulegone, and pyridine. The following NY Times article lists some ingredients allowed in the US, but not the European Union: potassium bromate, azodicarbonamide (or ADA), BHA and BHT , brominated vegetable oil (BVO), various food dyes (yellow dye #5 and 6, red dye #40), and certain farm animal drugs - the synthetic hormones  rBGH and  rBST, as well as ractopamine. Not mentioned in the article is that the European Union also bans the use of arsenic in chicken feed and formaldehyde (both allowed in US), and olestra or olean (a fat substitute). Unfortunately this is just a partial list.

One way to avoid problematic ingredients is to read labels and avoid foods with names that aren't real foods and that you don't know what they are. By the way, "natural flavors" are also laboratory concoctions - they're so pervasive in foods nowadays that they're tough to avoid, but one can try. From the "Ask Well" column by R.C. Rabin in the NY Times: What Foods Are Banned in Europe but Not Banned in the U.S.?

Q. What foods are banned in Europe that are not banned in the United States, and what are the implications of eating those foods?

A. The European Union prohibits or severely restricts many food additives that have been linked to cancer that are still used in American-made bread, cookies, soft drinks and other processed foods. Europe also bars the use of several drugs that are used in farm animals in the United States, and many European countries limit the cultivation and import of genetically modified foods.  ...continue reading "Food Ingredients Banned in Europe But Not USA"

Published on Leave a comment on Health Stories to Follow in 2019

New research is published every day, but only some studies are big research stories or game-changers. The following are what I consider some of the most memorable studies of 2018 – some in a good way, but some of the others have left me with a sense of horror. I think there will be follow-up research, so keep an eye out for more on these important topics.

Are we heading toward a time in the not so distant future when all men are infertile? (Due to exposure to all the endocrine disruptors around us.) Will All Men Eventually Be Infertile? This was posted September 5, 2018.

Researchers are now seriously investigating and finding evidence that microbes may be causing Alzheimer’s disease. This approach is rapidly finding support in the medical field, and may lead to possible ways to treat or prevent the disease. Possible Herpes Virus Link to Alzheimer’s Disease was posted July 13, 2018, and Herpes Viruses and Alzheimer's Disease on  June 22, 2018.

Type 2 Diabetes May Be Reversed With Weight Loss was posted August 10, 2018. This study and an earlier similar study from 2016 found that losing over 30 pounds over a short period can reverse type 2 diabetes - 46% in the 2018 study and 60% (in people who had it less than 10 years) in the earlier study.

More and more evidence is accumulating that certain diets are anti-inflammatory. Especially beneficial are diets rich in fruits, vegetables, seeds, nuts, legumes (beans), and whole grains - which also have a lot of fiber. This is exciting research because chronic low-grade inflammation is linked to a number of chronic diseases (heart disease, cancer, etc.). Fruits, Vegetables, and Whole Grains Lower Inflammation – posted August 1, 2018.

[Related to this last topic is one of the most eye-opening studies I have ever read on how what one eats has a quick effect on gut microbes and health of the gut (including inflammation of the colon): Changing Diet Has Big Effect On Colon Cancer Risk – posted April 28, 2015.]

Published on Leave a comment on Some Types of Dental Floss Should Be Avoided

Dental floss coated with a "non-stick coating" has long been a concern of mine. Do the Teflon-like chemicals get into the person when a person is flossing teeth?

These chemical compounds (called per- and polyfluoroalkyl substances or PFASs) are linked to health problems (e.g. kidney and testicular cancer, semen quality, thyroid disease, immune system effects, and lowered sex and growth hormones in children) - so you want to avoid them if possible. It turns out these chemicals are shed into the person's mouth when flossing and can be measured in a person's blood.

Bottom line: avoid non-stick smooth dental floss such as Oral-B Glide dental floss (or when the dental floss label brags that it is similar to Glide dental floss). Use plain waxed or unwaxed floss instead.

Per- and polyfluoroalkyl substances (PFASs) are a group of chemicals used in a wide variety of consumer products because they have water- and grease-resistant properties. They are used in nonstick cookware, in food packaging (especially the paper wrappers and cardboard containers) , stain-resistant carpets, furniture, floor waxes, textiles, water-proof and stain-resistant clothing (such as Gore-tex fabric), and performance gear.

How do they get into us? Some ways: the chemicals can migrate out of food packaging into food, or can be released into the air and dust from carpets and upholstery treated with stain-resistant coatings. PFASs have been detected in water, soil, and in the bodies of almost all Americans!

This study (and others)  found that higher levels of  these chemicals in the body occur with the following: frequent consumption of prepared food in coated cardboard containers, having stain-resistant carpets or furniture, using Oral-B Glide dental floss, and living in a city served by a PFAS-contaminated water supply.

It may not be possible to totally avoid all PFASs, but one can lower exposure to them (for example, don't have stain-resistant carpets in the house or apartment, and try to eat less fast-food).

From Medical Xpress: Dental flossing and other behaviors linked with higher levels of toxic chemicals in the body        ...continue reading "Some Types of Dental Floss Should Be Avoided"

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Published on 9 Comments on Sinusitis Success Stories

Today's topic: sinusitis success stories. For those suffering from chronic sinusitis or frequent sinus infections it sounds incredible, doesn't it? For more than 5 years I've posted about the probiotic Lactobacillus sakei and how it can successfully treat sinusitis - both chronic sinusitis and  acute sinusitis (sinus infections). Back in January 2013 I read a study by Abreu et al (2012) that the sinus microbiome (microbial community) in people with chronic sinusitis was imbalanced and that this beneficial bacteria could be a possible treatment. I had suffered from chronic sinusitis for years, so of course I went searching for Lactobacillus sakei. It wasn’t in any probiotics at the time, but I did find it in kimchi. Through experimentation I (and my family) successfully treated our sinusitis by dabbing and smearing a little of the kimchi juice in the nostrils once or twice a day. It felt miraculous!

By the end of 2013 I started this blog to get the word out about Lactobacillus sakei, and to also hear the experiences of others. (See results post) In the last 5 years I have heard from hundreds of people, including lots of sinusitis success stories with Lactobacillus sakei – especially using kimchi, sauerkraut made with garlic, sausage starter cultures such as Bactoferm F-RM-52, and recently with the sinusitis probiotic Lanto Sinus, which was introduced in 2018. When a Lactobacillus sakei product works as a sinusitis treatment for a person it feels absolutely wonderful and amazing. Sinus health after years of suffering! Unfortunately, it appears that Lactobacillus sakei may not work for everyone - only trying it determines if it works and how well.

The following are excerpts of some of the sinusitis success stories that people have reported - almost all are from comments after posts on this site, and a few from emails to me. Sometimes we need to hear successful treatment stories, especially if we’ve been struggling with sinusitis for a long time. Just keep in mind that these are stories of people experimenting on their own - how they used Lactobacillus sakei varies and their experiences vary. (See Sinusitis Treatment Summary for methods). Note that in Feb. 2019 the Lacto Sinus name was changed to Lanto Sinus in order to get a trademark - but the product remains exactly the same.

J. October 2017
So glad I found this site! Have been struggling with chronic sinus and gut issues go over 20 years after several rounds of antibiotics.
Immediately after reading thru this I put a dab of Kimchi juice up each nostril (had some on hand, as I eat a lot of fermented veggies). I could tell almost immediately that something was happening. Almost felt as if there was a duel going on in my sinuses between the kimchi probiotics and the nasties in my sinuses. Had some stuffiness and stiff neck but went to bed and slept great last night and woke up this morning with clearer sinuses and feeling better!

Jo. October 2015
Through the years I've tried everything for sinus infections and nothing but antibiotics helped. When I read about kimchi helping I tried that too. To my utter delight and relief, Sunja's white kimchi worked a miracle! I bought another 3 jars and keep it in the refrigerator for the next bout.

M. November 2018
I had great success in treating my chronic sinusitis with Lacto Sinus.
I’ve had sinus problems for 2 decades and tried all sorts of medicines and treatments, but nothing helped. Every single sore throat and every cold, no matter how minor, led to full-blown sinusitis and having to take antibiotics for weeks. I was always in fear of getting sick. And even when I was “healthy” I really wasn’t, I always had some symptoms. I would frequently wake up with a sore throat and with thick phlegm dripping down my throat.
I was desperate when I tried Lacto Sinus and was thrilled to see improvement within a day! I used it daily for over a week, then every other day for about 2 more weeks. And then I stopped because I didn’t need it anymore.
Getting my life and health back feels like a miracle! I don’t dread getting a cold or virus anymore – I just use some Lacto Sinus again if I get some sinus symptoms. I will always keep a bottle in my refrigerator.

T. January 2017  ...continue reading "Sinusitis Success Stories"

Published on Leave a comment on Can Exercise and Dietary Changes Help Older Adults With Thinking Problems?

Another study finding more benefits of exercise was recently published in the journal Neurology. The study by researchers at Duke University found that in older adults who were already experiencing  cognitive (thinking) problems, but did not have dementia - that after just 6 months of exercise they showed improvements in thinking. What were their original thinking problems? The individuals had difficulty concentrating, making decisions, or remembering, but it was not severe enough to be diagnosed as dementia. However, these persons were considered at risk for progressing to dementia.

The 160 individuals in the study were 55 years or older (mean age 65), mainly women, evenly divided between whites and minorities, were sedentary (didn't exercise), and had heart (cardiovascular) disease or were at risk for heart disease. They were randomly assigned to one of 4 groups: 1) aerobic exercise (with no dietary changes), 2) DASH diet (with no exercise), 3) DASH diet plus exercise, and 4) the control group, who had no dietary or exercise changes - they just received some educational phone calls. The study lasted 6 months, and there were no drop outs.

In the study, the aerobic exercises were done 3 times per week: 10 minutes of warm up exercises followed by 35 minutes of continuous walking or stationary cycling. The Dietary Approaches to Stop Hypertension or DASH diet is a heart healthy diet that emphasizes eating fruits, vegetables, whole grains, as well as fish, poultry, beans, and nuts. It stresses lowering the intake of salt (sodium), sweets, sugar sweetened beverages, and fatty foods (both trans fats and saturated fats). [Note that in many ways it's similar to the Mediterranean diet with its emphasis on fruits, vegetables, whole grains, legumes, seeds, nuts, and lowering intake of meat. Studies find cognitive benefits from the Mediterranean diet.]

The six months of exercising improved thinking skills called executive function - in both the exercise alone or exercise + DASH diet group. The largest improvements were in the exercise + DASH diet group (as compared to the control group, which actually showed decline in functioning). Executive function is a person's ability to regulate their own behavior, pay attention, organize and achieve goals, and was measured in this study with a group of cognitive tests (a "standard battery of neurocognitive tests"). These executive function improvements did not occur in the DASH diet alone group or the control group. The study found no improvement in memory or language fluency in any of the groups. The exercise alone, DASH diet alone, and the combined exercise and DASH group had other health benefits by the end of the study, for example they lowered their risk factors for heart disease. Other improvements: the exercise groups had improvements in insulin levels, and the DASH groups decreased their intake of blood pressure medicines.

To illustrate how amazing these results are: at the start of the study (baseline) all participants scored as if they were in their early 90s on cognitive tests - as if they were on average about 28 years older than their actual chronological age! Then at the end of 6 months, the persons in the exercise + DASH diet showed an improvement of almost 9 years on the tests. In contrast, the control group showed an approximately 6 month worsening performance. When researchers looked at physical markers of the exercisers, they found that physical improvements and improvements in heart disease risk factors (e.g. losing weight, lowering blood pressure) were correlated with executive functioning improvements.

Other studies have found related findings, such as higher physical activity and a Mediterranean diet is associated with lower levels of dementia. The researchers point out that there is growing evidence that combining several lifestyle factors (e.g., exercise, not smoking, a healthy diet, lowering salt intake) and not just exercise alone, has the best results for better cognitive functioning among older adults. Bottom line: eat a diet rich in fruits, vegetables, whole grains, seeds, nuts and get exercise. Walking briskly, gardening, housework, walking up stairs - it all counts.  ...continue reading "Can Exercise and Dietary Changes Help Older Adults With Thinking Problems?"

Published on Leave a comment on Can Exercise Be As Effective As Blood Pressure Medications In Lowering Blood Pressure?

Once again, a study found health benefits from exercise. This time a large review of studies found that the blood pressure lowering effect of exercise for persons with high blood pressure (hypertension) appears to be similar to that of commonly used blood-pressure (antihypertensive) medications. The study was designed to compare the effect of exercise and medications on systolic blood pressure (greater than 140 mmHg). Unfortunately no study directly compared the two, but the researchers were able to draw conclusions from 391 studies that had used randomly controlled trials (people assigned randomly to different conditions).

The American and UK researchers found that all programs of exercise and all blood pressure medications lowered blood pressure. They did find greater reductions in blood pressure in taking blood pressure lowering medications vs just exercise ("structured exercise regimens"), but pointed out that when studies just focused on people with high blood pressure (instead of everyone), then the results looked more impressive. Meaning the higher the blood pressure, the more effective the exercise.

Other findings: They did not observe a dose-response relationship between exercise intensity and blood pressure reduction. They found that even low-intensity exercise may be effective in reducing blood pressure. The researchers stressed the need for studies that directly compare  exercise programs to blood pressure medications, but point out that pharmaceutical companies are the ones doing the vast majority of studies and they don't have any incentive to do such a study (it could mean the loss of profits from medicines!). Many of the studies compared blood pressure medicines + exercise vs just blood pressure medicines. Thus the researchers said the topic of exercise and blood pressure is currently under studied.

Bottom line: get out and move, move, move for your health! All activity and movement is better than none. Yes, it's easier to just take daily pills, but all medications have side-effects and cost money. Exercise is free and the health benefits are many. Some health benefits of exercise from other studies: lowers blood pressure, lower risk of heart (cardiovascular) disease, lower the waist circumference (get rid of belly rolls!), and lowers triglyceride levels (in the blood).

From Science Daily: Exercise may be as effective as prescribed drugs to lower high blood pressure

Exercise may be as effective as prescribed drugs to lower high (140 mm Hg) blood pressure, suggests a pooled analysis of the available data, in what is thought to be the first study of its kind, and published online in the British Journal of Sports Medicine.   ...continue reading "Can Exercise Be As Effective As Blood Pressure Medications In Lowering Blood Pressure?"

Published on Leave a comment on Magnesium Regulates Vitamin D Levels In the Body?

The results of a recent study by Vanderbilt University may help explain why some people have difficulty raising their low vitamin D levels - it may be that their magnesium levels are low. It appears that magnesium may regulate vitamin D levels - when vitamin D levels are low, magnesium supplementation raises vitamin D levels, and when vitamin D levels are high, magnesium supplementation lowers them to a normal level.

What are good food sources of magnesium? Magnesium is found in many plant and animal foods and beverages. Good sources of magnesium include green leafy greens, legumes (beans), whole grains, nuts, dark chocolate, and fatty fish such as salmon. Foods containing dietary fiber generally provide magnesium. By the way, dietary surveys of people in the United States consistently show that intakes of magnesium are lower than recommended amounts. From Medical Xpress:

Study shows magnesium optimizes vitamin D status

A randomized trial by Vanderbilt-Ingram Cancer Center researchers indicates that magnesium optimizes vitamin D status, raising it in people with deficient levels and lowering it in people with high levels. 

...continue reading "Magnesium Regulates Vitamin D Levels In the Body?"